Results 71 to 80 of about 30,642,264 (240)

On‐Chip Photonic Neural Network Architectures

Advanced Optical Materials, EarlyView.
This review presents a comprehensive overview of on‐chip photonic neural network architectures, covering key photonic building blocks, representative network types, and emerging applications. Recent advances, implementation challenges, and future directions are examined, highlighting the potential of integrated photonics to enable ultrafast, energy ...
Seokjin Hong, Berkay Neseli, Seungyeon Cho, Seungsoo Lee, Yeonjun Kim, Seungyoon Choi, Hyo‐Hoon Park, Hamza Kurt   +7 more
wiley   +1 more source

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART. [PDF]

, 2019
The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years.
von Siebenthal, Chantal, Bachmann, Nadine, Battegay, Manuel, Yerly, Sabine, Perreau, M., Fellay, Jaques, Vongrad, Valentina, Battegay, M., Böni, J., Swiss HIV Cohort Study, Günthard, Huldrych F., Neumann, Kathrin, Metzner, Karin J, Bogojeska, Jasmina, Beerenwinkel, Niko; id_orcid, Metzner, K.J., Klimkait, Thomas, Roth, V., Thorball, C.W., Kouyos, R.D., Beerenwinkel, N., Yerly, S., Yerly Ferrillo, Sabine, Wieser, M., Bernasconi, E., Vongrad, V., von Siebenthal, C., Günthard, Huldrych F, Kouyos, Roger D., Hoffmann, Matthias, Parbhoo, Sonali, Beerenwinkel, Niko, Parbhoo, S., Cavassini, M., Böni, Jürg, Bogojeska, J., Fellay, J., Rauch, A., Kok, Y.L., Bernasconi, Enos, Kouyos, Roger D, and the Swiss HIV Cohort Study, Roth, Volker, Kok, Yik Lim, Borghesi, Alessandro, Rauch, Andri, Neumann, K., Borghesi, A., Hoffmann, M., Thorball, Christian W, Günthard, H.F., Bachmann, N., Klimkait, T., Turk, T., Thorball, Christian W., Metzner, Karin J., Turk, Teja, Perreau, Matthieu, Wieser, Mario, Cavassini, Matthias   +59 more
core   +2 more sources

Microglial Cells: The Main HIV-1 Reservoir in the Brain [PDF]

Frontiers in Cellular and Infection Microbiology, 2019
Despite efficient combination of the antiretroviral therapy (cART), which significantly decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been achieved. Hidden HIV-1 in cellular and anatomic reservoirs is the major hurdle toward a functional cure. Microglial cells, the Central Nervous system (CNS) resident macrophages,
Wallet, Clémentine, de Rovere, Marco, van Assche, Jeanne, Daouad, Fadoua, de Wit, Stéphane, Gautier, Virginie, Mallon, Patrick W. G., Marcello, Alessandro, van Lint, Carine, Rohr, Olivier, Schwartz, Christian   +10 more
openaire   +5 more sources

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Dolutegravir reshapes the genetic diversity of HIV-1 reservoirs [PDF]

Journal of Antimicrobial Chemotherapy, 2017
Better understanding of the dynamics of HIV reservoirs under ART is a critical step to achieve a functional HIV cure. Our objective was to assess the genetic diversity of archived HIV-1 DNA over 48 weeks in blood cells of individuals starting treatment with a dolutegravir-based regimen.Eighty blood samples were prospectively and longitudinally ...
Gantner, Pierre, Lee, Guinevere Q., Rey, David, Mesplede, Thibault, Partisani, Marialuisa, Cheneau, Christine, Beck-Wirth, Geneviève, Faller, Jean-Pierre, Mohseni-Zadeh, Mahsa, Martinot, Martin, Wainberg, Mark A., Fafi-Kremer, Samira   +11 more
openaire   +3 more sources

Disease progression in Human Immunodeficiency Virus type 1 infected viraemic controllers [PDF]

, 2012
PhDBackground: The mechanism of CD4+ T-cell decline in Human Immunodeficiency Virus-1 (HIV-1) infection is unclear, but the association with plasma HIV-1 RNA-load suggests viral replication is involved.
Groves, Katherine Claire
core   +4 more sources

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Regulatory T cells: the ultimate HIV reservoir?

Journal of Virus Eradication, 2018
Despite significant advances in the understanding of HIV-1 infection, a cure remains out of reach. This is, in part, due to a long-lived HIV-1 reservoir in resting CD4+ T cells, which do not express viral antigens, and thus are invisible to the immune ...
Joseph Rocco, John W. Mellors, Bernard J.C. Macatangay   +2 more
doaj   +1 more source

Nicotinamide Metabolism Constrains Memory CD8+ T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

Advanced Science, EarlyView.
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang, Xiaoqian Fan, Yifan Huang, Chang Yao, Jixing Fan, Yu Ping, Xuan Zhao, Congcong Li, Chunyi Shen, Jiqi Shan, Jinyan Liu, Shengdian Wang, Zhen Zhang, Yi Zhang   +13 more
wiley   +1 more source

Role of the HIV-1 Reservoir to Maintain Viral Suppression in a Simplified Strategy for the Long-Term Management of HIV-1 Infection (The SIMPL’HIV Trial). [PDF]

, 2022
HIV-1 reservoir size and dynamics are promising parameters to ensure the safe prescription of simplified maintenance antiretroviral therapy in chronically HIV-1 infected patients.
Decosterd, Laurent A., Decosterd, Laurent A, Yerly, Sabine, Günthard, Huldrych F., Buzzi, Marta, Schmid, Patrick, Limacher, Andreas, Braun, Dominique L., Günthard, Huldrych F, Neumann, Kathrin, Metzner, Karin J, Branca, Mattia, Wandeler, Gilles, Metzner, Karin J., Vernazza, Pietro, Sculier, Delphine, Calmy, Alexandra, Stoeckle, Marcel, Bernasconi, Enos, Cavassini, Matthias, Braun, Dominique L, Marinosci, Annalisa   +21 more
core   +2 more sources