Results 91 to 100 of about 34,607 (204)

Immune checkpoints and the HIV-1 reservoir: proceed with caution

Journal of Virus Eradication, 2016
Successfully identifying and targeting immune checkpoints on latently HIV-1-infected CD4+ T cells could be a key component in HIV-1 eradication therapies [1,2]. Immune checkpoints are negative regulators of: (i) T cell activation; (ii) T cell proliferation; and (iii) effector functions including cytokine production [3].
Rikke Olesen, Steffen Leth, Rasmus Nymann, Lars Østergaard, Ole S. Søgaard, Paul W. Denton, Martin Tolstrup   +6 more
openaire   +3 more sources

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou, Paschalis Karakasis, Panagiotis Theofilis, Konstantinos Pamporis, Panayotis K. Vlachakis, Anastasios Apostolos, Nikolaos Ktenopoulos, Barbara Fyntanidou, Efstratios Karagiannidis, Dimitrios Patoulias, Antonios P Antoniadis, Nikolaos Fragakis   +11 more
wiley   +1 more source

Factors associated with unquantifiable total HIV-1 DNA in peripheral blood in persons living with HIV: An observational study

Journal of Virus Eradication
Background: The human immunodeficiency virus type 1 (HIV-1) cannot be eradicated even with suppressive antiretroviral therapy because its retrotranscribed genome integrates into the DNA of host cells, creating a long-term reservoir.
Aurélie Ram, Vanessa Rascon Velasco, Gilbert Mchantaf, Véronique Avettand-Fénoël, Jean-Paul Viard   +4 more
doaj   +1 more source

Ruminants Epidemiology, Spatial Clustering and Multivariate Risk Modelling of Cutaneous Leishmaniasis in District Bajaur, Pakistan

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
This study investigated the epidemiology, risk factors and spatial distribution of cutaneous leishmaniasis in District Bajaur, Pakistan. Higher prevalence was observed among young males during summer, with lesions mainly on exposed body parts. Spatial analysis identified Khar, Loe Mamund and Salarzai as hotspots, highlighting the need for targeted ...
Murad Ali Khan, Jawad Ali, Zohaib Ali, Abdur Rehman, Muhammad Shoib, Sadaf Fayaz, Rifat Ullah Khan, Shabana Naz, Naseer Khan Momand, Antonella Perillo, Ibrahim A. Alhidary   +10 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, Volume 16, Issue 6, Page 1132-1141, June 2026.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Latency Reversing Agents and the Road to an HIV Cure

Pathogens
HIV-1 infection cannot be cured due to the presence of HIV-1 latently infected cells. These cells do not produce the virus, but they can resume virus production at any time in the absence of antiretroviral therapy. Therefore, people living with HIV (PLWH)
Louis Tioka, Rafael Ceña Diez, Anders Sönnerborg, Maarten A. A. van de Klundert   +3 more
doaj   +1 more source

Traditional Respiratory Remedies From Anatolia: Ethnobotanical Insights and Bioactive Properties

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
ABSTRACT Respiratory disorders, ranging from acute viral infections such as influenza and bronchitis to chronic inflammatory conditions including chronic obstructive pulmonary disease, asthma, emphysema, and pneumonia, represent a major global health burden, affecting millions annually. Traditional Anatolian folk medicine has long relied on plant‐based
Golshan Zare, Yağmur Diker, Irem Tatlı Çankaya, Emran Habibi, Satyajit D. Sarker, Lutfun Nahar   +5 more
wiley   +1 more source

Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency

Frontiers in Cellular and Infection Microbiology, 2023
Alexander O. Pasternak, Olivier Rohr, Olivier Rohr, Carine Van Lint, Anna Kula-Pacurar   +4 more
doaj   +1 more source

Protein post-translational modification regulates HIV-1 latency

生物医学转化
AIDS is a disease named acquired immunodeficiency syndrome, which caused by the human immunodeficiency virus (HIV). HIV can be divided into HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is a global pandemic that has caused serious harm.
Wu Tong, Wang Tiantian, Deng Kai
doaj   +1 more source