Results 91 to 100 of about 30,642,264 (240)

HIV-1 transmissions during asymptomatic infection : exploring the impact of changes in HIV-1 viral load due to coinfections [PDF]

, 2015
High HIV-1 plasma viral loads (PVLs) in sub-Saharan Africa, partly because of high rates of coinfection, may have been one of the drivers of the “explosive” epidemics seen in that region.
Baggaley, Rebecca F, Baggaley, Rebecca F., Hollingsworth, T Déirdre, Hollingsworth, T. Déirdre   +3 more
core   +1 more source

A case series of necrotizing periodontal diseases in hospitalized patients: What hasn't been said yet?

Clinical Advances in Periodontics, EarlyView.
Abstract Background Necrotizing periodontal diseases (NPDs) are uncommon and severe inflammatory conditions characterized by tissue necrosis, painful ulceration, and rapid clinical progression, frequently associated with systemic immunosuppression. Limited data exist regarding their clinical presentation and management in hospital settings.
Osmaria Letthycia Carvalho Leal, Fernanda Bortolotto, Mariana Cristina Manoel, Gabriela Silveira de Araújo, Ana Carolina Fragoso Motta, Leandro Dorigan de Macedo, Lara Maria Alencar Ramos Innocentini, Joab Cabral Ramos, Isabel Schausltz Pereira Faustino   +8 more
wiley   +1 more source

Discontinuous sequence change of human immunodeficiency virus (HIV) type 1 env sequences in plasma viral and lymphocyte-associated proviral populations in vivo:implications for models of HIV pathogenesis [PDF]

, 1991
Sequence change in different hypervariable regions of the external membrane glycoprotein (gp120) of human immunodeficiency virus type 1 (HIV-1) was studied.
Zhang, L Q, Brown, A J, Balfe, P, McOmish, F, Ludlam, C A, Simmonds, P   +5 more
core  

Towards an HIV-1 cure: measuring the latent reservoir [PDF]

Trends in Microbiology, 2015
The latent reservoir (LR) of HIV-1 in resting memory CD4(+) T cells serves as a major barrier to curing HIV-1 infection. While many PCR- and culture-based assays have been used to measure the size of the LR, correlation between results of different assays is poor and recent studies indicate that no available assay provides an accurate measurement of ...
Katherine M, Bruner, Nina N, Hosmane, Robert F, Siliciano   +2 more
openaire   +2 more sources

Empirical PK/PD Model for Differentiating Intrinsic Dosing Rules by Therapeutic Indication With Relevance for HIV‐1 Latency Reversal

Clinical Pharmacology &Therapeutics, EarlyView.
Romidepsin (RMD), an FDA‐approved histone deacetylase inhibitor for treating cancer, demonstrates potent latency‐reversing activity in vitro but has yielded suboptimal outcomes in kick‐and‐kill HIV‐cure trials when administered as a 5 mg/m2 infusion.
Lauren A. R. Tompkins, Amanda Poliseno, Airlie Ward, Edward P. Browne, Cassandra Gilbert, Craig Sykes, Angela D. M. Kashuba, Mackenzie L. Cottrell   +7 more
wiley   +1 more source

HIV-1 Reservoir Size and Diversity Among Acute-Infected Individuals

, 2018
Early combined antiretroviral treatment (cART) of HIV infection aims to limit the seeding of the viral reservoir in the initial phase of infection, and, consequently, decrease the intrahost viral diversity.
Cardoso, Sandra Wagner (5830811), Morgado, Mariza Gonçalves, Delatorre, Edson (5830673), Guimarães, Monick Lindenmeyer (5830820), Côrtes, Fernanda Heloise, Ferreira, Ana Cristina Garcia (5830808), Veloso, Valdilea Gonçalves (5830817), Leite, Thaysse Ferreira, Guimarães, Monick Lindenmeyer, Ferreira, Ana Cristina Garcia, Veloso, Valdilea Gonçalves, Delatorre, Edson, Leite, Thaysse Ferreira (5830802), Grinsztejn, Beatriz, Côrtes, Fernanda Heloise (5830805), Morgado, Mariza Gonçalves (5830679), Grinsztejn, Beatriz (5830814), Cardoso, Sandra Wagner   +17 more
core   +1 more source

Redefining the Viral Reservoirs that Prevent HIV-1 Eradication [PDF]

Immunity, 2012
This Perspective proposes definitions for key terms in the field of HIV-1 latency and eradication. In the context of eradication, a reservoir is a cell type that allows persistence of replication-competent HIV-1 on a timescale of years in patients on optimal antiretroviral therapy. Reservoirs act as a barrier to eradication in the patient population in
Eisele, Evelyn, Siliciano, Robert F.
openaire   +2 more sources

Advancements in single-cell techniques for examining the HIV reservoir: pathways to a cure

mBio
Human immunodeficiency virus (HIV) is largely incurable, due to the presence of a viral reservoir, which primarily consists of resting CD4+ T cells and other long-lived cells like macrophages.
Nokuzola Mbhele, Benjamin Chimukangara, Lynn Tyers, Frank Maldarelli, Andrew D. Redd   +4 more
doaj   +1 more source

Mango Seed Valorization: Sustainable Source of Nutrients, Bioactives, and Value‐Added Applications

Food Chemistry International, EarlyView.
Highlighting mango seed as a valuable yet overlooked by‐product, promoting its utilization and reducing agroindustrial waste. ABSTRACT Mango (Mangifera indica L.) is one of the most widely cultivated tropical fruits, generating large quantities of by‐products during processing, with mango seed representing 20%–25% of the whole fruit weight ...
Priyanka Yadav, Mazia Ahmed, Unaiza Iqbal, Pinki Saini   +3 more
wiley   +1 more source

The Impact of Domestic Public Health Spending on Health Outcomes in Sub‐Saharan Africa: Evidence From Disability‐Adjusted Life Years

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Sub‐Saharan Africa (SSA) continues to experience a high and uneven disease burden, mainly from HIV/AIDS, tuberculosis, and malaria. As external funding declines, the strategic allocation of domestic public health spending (DPHS) becomes crucial.
Wa Ntita Serge Kabongo, Josue Mbonigaba
wiley   +1 more source