Results 111 to 120 of about 34,607 (204)
Guidelines for Essential Trauma Care: Second Edition (2026)
Injury is a major cause of death and disability globally, with the highest burden in low‐ and middle‐income countries (LMICs). Strengthening the organization and planning for trauma care (care of the injured) can improve care and lower mortality. In 2004, the International Association for Trauma Surgery and Intensive Care (IATSIC) and the World Health ...
Charles Mock +41 more
wiley +1 more source
T‐Cell Biology in the Female Reproductive Tract: Relevance to HIV Infection
ABSTRACT Worldwide, most HIV infections occur across a mucosal surface during sexual contact, with women accounting for nearly half of reported new HIV infections across the globe in 2024. Most new infections in women and girls are believed to involve transmission across mucosal surfaces of the lower reproductive tract, which includes the vagina and ...
Barbara L. Shacklett +2 more
wiley +1 more source
ABSTRACT HIV transmission through the female and male reproductive tracts is governed by spatially organized interactions between virions, epithelial barriers, and tissue‐resident immune cells. Imaging approaches have been central to defining these earliest events, progressing from classical histology and immunohistochemistry (IHC) to modern ...
Ann M. Carias +3 more
wiley +1 more source
Immune Modulation of HIV-1 Reservoir Size in Early-Treated Neonates. [PDF]
Hartana CA +15 more
europepmc +1 more source
The HIV Reservoir in the Female Reproductive Tract
ABSTRACT Antiretrovirals can prevent the spread of replicating HIV within the host and decrease the virus in plasma to levels undetectable in clinical assays, and in genital secretions to untransmissible levels. However, during effective treatment with antiretrovirals, infectious HIV persists lifelong because the virus integrates into the host's DNA ...
Sean M. Hughes, Lisa M. Frenkel
wiley +1 more source
Single-cell multiomic understanding of HIV-1 reservoir at epigenetic, transcriptional, and protein levels. [PDF]
Wong M, Wei Y, Ho YC.
europepmc +1 more source
Abstract Objectives Low‐level viremia (LLV) has been associated with an increased risk of virological failure among adults on antiretroviral therapy (ART). However, evidence on the clinical implications of LLV among adolescents living with HIV remains limited.
Zea Leon +7 more
wiley +1 more source
Phenotypic signatures of immune selection in HIV-1 reservoir cells. [PDF]
Sun W +12 more
europepmc +1 more source
ABSTRACT Nonhuman primates (NHPs) have emerged as an indispensable model for studying HIV pathogenesis, vaccines, and therapies. The development of chimeric Simian/Human immunodeficiency viruses (SHIVs) has been constructed by inserting HIV‐1 Env into the SIV (usually SIVmac239) backbone, and these have proved essential for evaluating HIV neutralizing ...
A. J. Hessell +2 more
wiley +1 more source
Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir. [PDF]
Pardons M +13 more
europepmc +1 more source

