Predicting Post-treatment HIV Remission: Does Size of the Viral Reservoir Matter? [PDF]
Frontiers in Microbiology, 2021 Combination antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) replication and improves immune function. However, due to the persistence of long-lived HIV reservoirs, therapy interruption almost inevitably leads to a fast viral ...
Alexander O. Pasternak +2 more
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Intact Proviral DNA Analysis of the Brain Viral Reservoir and Relationship to Neuroinflammation in People with HIV on Suppressive Antiretroviral Therapy. [PDF]
Viruses, 2023 HIV establishes a persistent viral reservoir in the brain despite viral suppression in blood to undetectable levels on antiretroviral therapy (ART). The brain viral reservoir in virally suppressed HIV+ individuals is not well-characterized. In this study,
Gabuzda D +4 more
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AKT signaling modulates latent viral reservoir viability in HIV-1-infected blood-brain barrier pericytes. [PDF]
J Biol Chem, 2023 Despite antiretroviral therapy (ART), chronic forms of HIV-associated neurocognitive disorders (HAND) affect an estimated 50% of individuals living with HIV, greatly impacting their quality of life.
Naranjo O +9 more
europepmc +4 more sources
Viral Reservoir in Early-Treated Human Immunodeficiency Virus-Infected Children and Markers for Sustained Viral Suppression [PDF]
Clinical Infectious Diseases, 2021 BACKGROUND The impact of very early infant treatment on HIV reservoir, and markers for treatment success, require study. METHODS The Early Infant Treatment Study (EIT) enrolled 40 children living with HIV started on antiretroviral treatment (ART) at
Daniel Kuritzkes +2 more
exaly +3 more sources
BiomoleculesHepatitis B virus (HBV) is a major global health issue, with an estimated 254 million people living with chronic HBV infection worldwide as of 2022. Chronic HBV infection is the leading cause of cirrhosis and liver cancer.
André Boonstra, Gulce Sari
doaj +4 more sources
HIV Subtype and Nef-Mediated Immune Evasion Function Correlate with Viral Reservoir Size in Early-Treated Individuals [PDF]
Journal of Virology, 2019 While combination antiretroviral therapies (cART) have transformed HIV infection into a chronic manageable condition, they do not act upon the latent HIV reservoir and are therefore not curative. As HIV cure or remission should be more readily achievable
Mark Brockman +2 more
exaly +3 more sources
KLRG1 expression on natural killer cells is associated with HIV persistence, and its targeting promotes the reduction of the viral reservoir. [PDF]
Cell Rep Med, 2023 Summary Human immunodeficiency virus (HIV) infection induces immunological dysfunction, which limits the elimination of HIV-infected cells during treated infection. Identifying and targeting dysfunctional immune cells might help accelerate the purging of
Astorga-Gamaza A +16 more
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Broadly neutralizing antibody-derived CAR T cells reduce viral reservoir in individuals infected with HIV-1. [PDF]
J Clin Invest, 2021 BACKGROUND Chimeric antigen receptor (CAR)-modified T cells have emerged as a novel approach to treat malignant tumors. This strategy has also been proposed for the treatment of HIV-1 infection.
Liu B +21 more
europepmc +2 more sources
Transient viral replication during analytical treatment interruptions in SIV infected macaques can alter the rebound-competent viral reservoir. [PDF]
PLoS Pathog, 2021 Analytical treatment interruptions (ATIs) of antiretroviral therapy (ART) play a central role in evaluating the efficacy of HIV-1 treatment strategies targeting virus that persists despite ART.
Immonen TT +7 more
europepmc +2 more sources
For Viral Reservoir Studies, Timing Matters. [PDF]
Trends in Microbiology, 2019 New strategies to eliminate persistent HIV-1 during therapy will benefit from animal models, such as non-human primates infected with simian immunodeficiency viruses (SIV) or chimeras (SHIV).
B. Horsburgh, S. Palmer
semanticscholar +3 more sources