Predicting Post-treatment HIV Remission: Does Size of the Viral Reservoir Matter? [PDF]
Frontiers in Microbiology, 2021 Combination antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) replication and improves immune function. However, due to the persistence of long-lived HIV reservoirs, therapy interruption almost inevitably leads to a fast viral ...
Alexander O. Pasternak +2 more
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Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy. [PDF]
PLoS Computational Biology, 2009 Although potent combination therapy is usually able to suppress plasma viral loads in HIV-1 patients to below the detection limit of conventional clinical assays, a low level of viremia frequently can be detected in plasma by more sensitive assays ...
Libin Rong, Alan S Perelson
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BiomoleculesHepatitis B virus (HBV) is a major global health issue, with an estimated 254 million people living with chronic HBV infection worldwide as of 2022. Chronic HBV infection is the leading cause of cirrhosis and liver cancer.
André Boonstra, Gulce Sari
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Arsenic trioxide-induced apoptosis contributes to suppression of viral reservoir in SIV-infected rhesus macaques [PDF]
Microbiology Spectrum, 2023 Yizi He, Qing Yang, Ziyu Wen
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HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV [PDF]
Journal of Infectious Diseases, 2023 Yolanda Eby +2 more
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Viral Reservoir in Early-Treated Human Immunodeficiency Virus-Infected Children and Markers for Sustained Viral Suppression [PDF]
Clinical Infectious Diseases, 2021 Gbolahan Ajibola +2 more
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mBio, 2022 Combined Antiretroviral therapy (cART) suppresses HIV replication but fails to eradicate the virus, which persists in a small pool of long-lived latently infected cells. Immune activation and residual inflammation during cART are considered to contribute
Julia Rubione +20 more
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Glycoengineering of AAV-delivered monoclonal antibodies yields increased ADCC activity
Molecular Therapy: Methods & Clinical Development, 2021 The absence of fucose on asparagine-297 of the human immunoglobulin G (IgG) heavy chain has been shown to enhance antibody-dependent cellular cytotoxicity (ADCC) activity by 10- to 100-fold compared to fucosylated antibody. Our lab is studying the use of
James M. Termini +4 more
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HIV-1 Infection of Long-Lived Hematopoietic Precursors In Vitro and In Vivo
Cells, 2022 Latent reservoirs in human-immunodeficiency-virus-1 (HIV-1)-infected individuals represent a major obstacle in finding a cure for HIV-1. Hematopoietic stem and progenitor cells (HSPCs) have been described as potential HIV-1 targets, but their roles as ...
Sebastian Renelt +11 more
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Microglial HIV-1 Expression: Role in HIV-1 Associated Neurocognitive Disorders
Viruses, 2021 The persistence of HIV-1 viral reservoirs in the brain, despite treatment with combination antiretroviral therapy (cART), remains a critical roadblock for the development of a novel cure strategy for HIV-1.
Hailong Li +4 more
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