Results 21 to 30 of about 84,140 (293)
For Viral Reservoir Studies, Timing Matters [PDF]
Trends in Microbiology, 2019 New strategies to eliminate persistent HIV-1 during therapy will benefit from animal models, such as non-human primates infected with simian immunodeficiency viruses (SIV) or chimeras (SHIV). Understanding the genetic composition of SIV and SHIV reservoirs during therapy is therefore crucial for the future application of this model.
Bethany A, Horsburgh, Sarah, Palmer
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Monocytes and Macrophages as Viral Targets and Reservoirs [PDF]
International Journal of Molecular Sciences, 2018 Viruses manipulate cell biology to utilize monocytes/macrophages as vessels for dissemination, long-term persistence within tissues and virus replication. Viruses enter cells through endocytosis, phagocytosis, macropinocytosis or membrane fusion. These processes play important roles in the mechanisms contributing to the pathogenesis of these agents and
Nikitina, Ekaterina +3 more
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Southern African Journal of HIV Medicine, 2020 Background: While combined antiretroviral therapy (cART) allows near-normal life expectancy for people living with human immunodeficiency virus (HIV), it is unable to cure the infection and so life long treatment is required.
Alexander M.L. Hayes
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Adipose Tissue in SARS-CoV-2 Viral Tropism, Viral Replication, and the Concept of a Viral Reservoir: An Update. [PDF]
Obesity (Silver Spring)ABSTRACT Since the onset of the COVID‐19 pandemic, obesity has been consistently associated with worse clinical outcomes. In 2020, we hypothesized that adipose tissue (AT) might serve as a viral reservoir and amplifier of immune responses in SARS‐CoV‐2 infection. Five years on, accumulating evidence supports this hypothesis.
Maher LC, Ryan PM, Caplice NM.
europepmc +3 more sources
Lnc(ing)RNAs to the “shock and kill” strategy for HIV-1 cure
Molecular Therapy: Nucleic Acids, 2021 The advent of antiretroviral therapy almost 25 years ago has transformed HIV-1 infection into a manageable chronic condition, albeit still incurable. The inability of the treatment regimen to eliminate latently infected cells that harbor the virus in an ...
Saikat Boliar, David G. Russell
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Do ‘special’ viral reservoirs exist? [PDF]
Nature Reviews Microbiology, 2020 A recent analysis concludes that there is little evidence to support the notion that reservoir host affects the propensity for a virus to infect humans.
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AKT signaling modulates latent viral reservoir viability in HIV-1-infected blood-brain barrier pericytes. [PDF]
J Biol ChemDespite antiretroviral therapy (ART), chronic forms of HIV-associated neurocognitive disorders (HAND) affect an estimated 50% of individuals living with HIV, greatly impacting their quality of life.
Naranjo O +9 more
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Optimization of AAV vectors to target persistent viral reservoirs [PDF]
Virology Journal, 2021 AbstractGene delivery of antiviral therapeutics to anatomical sites where viruses accumulate and persist is a promising approach for the next generation of antiviral therapies. Recombinant adeno-associated viruses (AAV) are one of the leading vectors for gene therapy applications that deliver gene-editing enzymes, antibodies, and RNA interference ...
Rossana Colón-Thillet +2 more
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Residual inflammation and viral reservoirs [PDF]
Current Opinion in HIV and AIDS, 2016 HIV persists in cellular and anatomical reservoirs during antiretroviral therapy (ART). Viral persistence is ensured by a variety of mechanisms including ongoing viral replication and proliferation of latently infected cells. In this review, we summarize recent findings establishing a link between the unresolved levels of inflammation observed in ...
Marta, Massanella +2 more
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