Results 21 to 30 of about 1,595,225 (317)

Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host. [PDF]

Nat Microbiol, 2019
Bats are special in their ability to host emerging viruses. As the only flying mammal, bats endure high metabolic rates yet exhibit elongated lifespans. It is currently unclear whether these unique features are interlinked.
Ahn M, Anderson DE, Zhang Q, Tan CW, Lim BL, Luko K, Wen M, Chia WN, Mani S, Wang LC, Ng JHJ, Sobota RM, Dutertre CA, Ginhoux F, Shi ZL, Irving AT, Wang LF.   +16 more
europepmc   +2 more sources

Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile. [PDF]

Sci Transl Med, 2019
Antiretroviral treatment initiation immediately after birth reduces HIV-1 viral reservoir size and alters innate immune responses in neonates. Early to treat, early to thrive Timing of antiretroviral therapy (ART) initiation for HIV can influence viral ...
Garcia-Broncano P, Maddali S, Einkauf KB, Jiang C, Gao C, Chevalier J, Chowdhury FZ, Maswabi K, Ajibola G, Moyo S, Mohammed T, Ncube T, Makhema J, Jean-Philippe P, Yu XG, Powis KM, Lockman S, Kuritzkes DR, Shapiro R, Lichterfeld M.   +19 more
europepmc   +2 more sources

Qualitative plasma viral load determination as a tool for screening of viral reservoir size in PWH [PDF]

AIDS, 2022
Objective(s): Suppression of viral replication in patients on antiretroviral therapy (ART) is determined by plasma viral load (pVL) measurement. Whenever pVL reaches values below the limit of quantification, the qualitative parameter ’target detected’ or ’target not detected’ is available but often not reported to the clinician.
Laeremans, Thessa, D'haese, Sigrid, Aernout, Jonathan, Barbé, Kurt, Pannus, Pieter, Rutsaert, Sofie, Vancutsem, Ellen, Vanham, Guido, Necsoi, Coca, Spiegelaere, Ward De, Couttenye, Marie, Herssens, Natacha, Scheerder, Marie-Angélique De, Wit, Stéphane De, Vandekerckhove, Linos, Eric, Florence, Aerts, Joeri L, Allard, Sabine D   +17 more
openaire   +5 more sources

Short-Term Pegylated Interferon α2a Treatment Does Not Significantly Reduce the Viral Reservoir of Simian Immunodeficiency Virus-Infected, Antiretroviral Therapy-Treated Rhesus Macaques

Journal of Virology, 2018
The potential of type I interferons to reduce the viral reservoir has been recently studied in clinical trials in HIV-infected humans. However, given the lack of mechanistic data and the potential for safety concerns, a more comprehensive testing of IFN ...
Guido Silvestri, Ann Chahroudi, Maud Mavigner   +2 more
exaly   +2 more sources

The pathogenesis of zoonotic viral infections: Lessons learned by studying reservoir hosts [PDF]

Frontiers in Microbiology, 2023
Zoonotic viral infections that cause severe disease or even death in some people may be asymptomatic or mild in reservoir hosts. Comparison of the pathogenesis of these two host categories may potentially explain the difference in disease.
Lineke Begeman, Debby van Riel, Marion P. G. Koopmans, Marion P. G. Koopmans, Thijs Kuiken   +4 more
doaj   +3 more sources

Early and Highly Suppressive Antiretroviral Therapy Are Main Factors Associated With Low Viral Reservoir in European Perinatally HIV-Infected Children. [PDF]

J Acquir Immune Defic Syndr, 2018
Background: Future strategies aiming to achieve HIV-1 remission are likely to target individuals with small reservoir size. Setting: We retrospectively investigated factors associated with HIV-1 DNA levels in European, perinatally HIV-infected children ...
Tagarro A, Chan M, Zangari P, Ferns B, Foster C, De Rossi A, Nastouli E, Muñoz-Fernández MA, Gibb D, Rossi P, Giaquinto C, Babiker A, Fortuny C, Freguja R, Cotugno N, Judd A, Noguera-Julian A, Navarro ML, Mellado MJ, Klein N, Palma P, Rojo P.   +21 more
europepmc   +2 more sources

Adipose Tissue in SARS-CoV-2 Viral Tropism, Viral Replication, and the Concept of a Viral Reservoir: An Update. [PDF]

Obesity (Silver Spring)
ABSTRACT Since the onset of the COVID‐19 pandemic, obesity has been consistently associated with worse clinical outcomes. In 2020, we hypothesized that adipose tissue (AT) might serve as a viral reservoir and amplifier of immune responses in SARS‐CoV‐2 infection. Five years on, accumulating evidence supports this hypothesis.
Maher LC, Ryan PM, Caplice NM.
europepmc   +3 more sources

Modeling HIV persistence, the latent reservoir, and viral blips [PDF]

Journal of Theoretical Biology, 2009
HIV-1 eradication from infected individuals has not been achieved with the prolonged use of highly active antiretroviral therapy (HAART). The cellular reservoir for HIV-1 in resting memory CD4(+) T cells remains a major obstacle to viral elimination. The reservoir does not decay significantly over long periods of time but is able to release replication-
Libin Rong, Alan Perelson
exaly   +3 more sources

CD4:CD8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed HIV‐positive patients

Journal of the International AIDS Society, 2015
Absolute CD4 T cell count and plasma viral load have been established as predictors of HIV disease progression, and CD4 T cell count is used as an indicator for initiation of antiretroviral therapy. Following long‐term therapy, patients generally present
Vikram Mehraj, Jean-Pierre Routy, Kishanda Výboh   +2 more
exaly   +2 more sources

The immune gene repertoire of an important viral reservoir, the Australian black flying fox [PDF]

BMC Genomics, 2012
Bats are the natural reservoir host for a range of emerging and re-emerging viruses, including SARS-like coronaviruses, Ebola viruses, henipaviruses and Rabies viruses.
A. Papenfuss, M. Baker, Zhi-Ping Feng, M. Tachedjian, G. Crameri, C. Cowled, J. Ng, V. Janardhana, H. Field, Lin‐Fa Wang   +9 more
semanticscholar   +3 more sources