Results 21 to 30 of about 956,535 (302)
Microglial HIV-1 Expression: Role in HIV-1 Associated Neurocognitive Disorders
Viruses, 2021 The persistence of HIV-1 viral reservoirs in the brain, despite treatment with combination antiretroviral therapy (cART), remains a critical roadblock for the development of a novel cure strategy for HIV-1.
Hailong Li +4 more
doaj +1 more source
Confined aquifers as viral reservoirs [PDF]
Environmental Microbiology Reports, 2013 Summary Knowledge about viral diversity and abundance in deep groundwater reserves is limited. We found that the viral community inhabiting a deep confined aquifer in S outh A ustralia was more similar to reclaimed water communities ...
Smith, Renee J +9 more
openaire +3 more sources
mBio, 2022 Combined Antiretroviral therapy (cART) suppresses HIV replication but fails to eradicate the virus, which persists in a small pool of long-lived latently infected cells. Immune activation and residual inflammation during cART are considered to contribute
Julia Rubione +20 more
doaj +1 more source
Monocytes and Macrophages as Viral Targets and Reservoirs [PDF]
International Journal of Molecular Sciences, 2018 Viruses manipulate cell biology to utilize monocytes/macrophages as vessels for dissemination, long-term persistence within tissues and virus replication. Viruses enter cells through endocytosis, phagocytosis, macropinocytosis or membrane fusion. These processes play important roles in the mechanisms contributing to the pathogenesis of these agents and
Nikitina, Ekaterina +3 more
openaire +2 more sources
Optimization of AAV vectors to target persistent viral reservoirs [PDF]
Virology Journal, 2021 AbstractGene delivery of antiviral therapeutics to anatomical sites where viruses accumulate and persist is a promising approach for the next generation of antiviral therapies. Recombinant adeno-associated viruses (AAV) are one of the leading vectors for gene therapy applications that deliver gene-editing enzymes, antibodies, and RNA interference ...
Rossana Colón-Thillet +2 more
openaire +3 more sources
For Viral Reservoir Studies, Timing Matters [PDF]
Trends in Microbiology, 2019 New strategies to eliminate persistent HIV-1 during therapy will benefit from animal models, such as non-human primates infected with simian immunodeficiency viruses (SIV) or chimeras (SHIV). Understanding the genetic composition of SIV and SHIV reservoirs during therapy is therefore crucial for the future application of this model.
Bethany A, Horsburgh, Sarah, Palmer
openaire +2 more sources
Do ‘special’ viral reservoirs exist? [PDF]
Nature Reviews Microbiology, 2020 A recent analysis concludes that there is little evidence to support the notion that reservoir host affects the propensity for a virus to infect humans.
openaire +2 more sources
Southern African Journal of HIV Medicine, 2020 Background: While combined antiretroviral therapy (cART) allows near-normal life expectancy for people living with human immunodeficiency virus (HIV), it is unable to cure the infection and so life long treatment is required.
Alexander M.L. Hayes
doaj +1 more source
Viral dynamics during structured treatment interruptions of chronic human immunodeficiency virus type 1 infection [PDF]
, 2002 Although antiviral agents which block human immunodeficiency virus (HIV) replication can result in long-term suppression of viral loads to undetectable levels in plasma, long-term therapy fails to eradicate virus, which generally rebounds after a single ...
Ruiz, L +9 more
core +1 more source
Residual inflammation and viral reservoirs [PDF]
Current Opinion in HIV and AIDS, 2016 HIV persists in cellular and anatomical reservoirs during antiretroviral therapy (ART). Viral persistence is ensured by a variety of mechanisms including ongoing viral replication and proliferation of latently infected cells. In this review, we summarize recent findings establishing a link between the unresolved levels of inflammation observed in ...
Marta, Massanella +2 more
openaire +2 more sources