Results 41 to 50 of about 956,535 (302)
The influence of bat ecology on viral diversity and reservoir status [PDF]
Ecology and Evolution, 2020 AbstractRepeated emergence of zoonotic viruses from bat reservoirs into human populations demands predictive approaches to preemptively identify virus‐carrying bat species. Here, we use machine learning to examine drivers of viral diversity in bats, determine whether those drivers depend on viral genome type, and predict undetected viral carriers.
Cylita Guy +2 more
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Extracellular Vesicles as a New Promising Therapy in HIV Infection
Frontiers in Immunology, 2022 Combination antiretroviral therapy (cART) effectively blocks HIV replication but cannot completely eliminate HIV from the body mainly due to establishment of a viral reservoir.
Maria A. Navarrete-Muñoz +7 more
doaj +1 more source
Targeting viral reservoirs: ability of antiretroviral therapy to stop viral replication [PDF]
Current Opinion in HIV and AIDS, 2011 HIV infection is controlled but not cured by combination antiretroviral therapy. HIV may persist for a number of reasons, including ongoing cycles of HIV infection or viral persistence as latent, or HIV replication in long-lived cells containing HIV proviruses. Therapeutic consequences of these alternative mechanisms are significant and distinct.
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Frontiers in PharmacologyHIV-1 infection cannot be cured due to long-lived viral reservoirs formed by latently infected CD4+ T cells. “Shock and Kill” strategy has been considered to eliminate the viral reservoir and achieve a functional cure but the stimulation of cytotoxic ...
Mario Manzanares +22 more
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Viral and latent reservoir persistence in HIV-1-infected patients on therapy. [PDF]
PLoS Computational Biology, 2006 Despite many years of potent antiretroviral therapy, latently infected cells and low levels of plasma virus have been found to persist in HIV-infected patients. The factors influencing this persistence and their relative contributions have not been fully
Hwijin Kim, Alan S Perelson
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Bats and birds as viral reservoirs: A physiological and ecological perspective
Science of The Total Environment, 2021 (Uploaded by Plazi for the Bat Literature Project) The birds (class Aves) and bats (order Chiroptera, class Mammalia) are well known natural reservoirs of a diverse range of viruses, including some zoonoses. The only extant volant vertebrates, bats and birds have undergone dramatic adaptive radiations that have allowed them to occupy diverse ecological
Nabi, Ghulam +6 more
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Impacts of HIV Cure Interventions on Viral Reservoirs in Tissues [PDF]
Frontiers in Microbiology, 2019 HIV reservoirs persist in infected individuals despite combination antiretroviral therapy and can be identified in secondary lymphoid tissues, in intestinal tissues, in the central nervous system as well as in blood. Clinical trials have begun to explore effects of small molecule interventions to perturb the latent viral infection, but only limited ...
Paul W. Denton +4 more
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Applications of viral metagenomics in the veterinary field [PDF]
, 2010 Viral metagenomics provide a powerful technology to investigate the viral flora of healthy and sick animals. Using these methodologies, we gain a better understanding in the etiology of diseases, as well as deepen our knowledge into the viruses ...
Blomström, Anne-Lie
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Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir
eLife, 2018 Human dengue viruses emerged from primate reservoirs, yet paradoxically dengue does not reach high titers in primate models. This presents a unique opportunity to examine the genetics of spillover versus reservoir hosts.
Alex C Stabell +7 more
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VirusesGut-associated lymph nodes (GALNs) constitute an important anatomical reservoir during early and chronic human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) infection, but the fate of this compartment during terminal AIDS remains ...
Cong-Jiao Bai +7 more
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