Results 41 to 50 of about 1,595,225 (317)
HIV-1 Infection of Long-Lived Hematopoietic Precursors In Vitro and In Vivo
Cells, 2022 Latent reservoirs in human-immunodeficiency-virus-1 (HIV-1)-infected individuals represent a major obstacle in finding a cure for HIV-1. Hematopoietic stem and progenitor cells (HSPCs) have been described as potential HIV-1 targets, but their roles as ...
Sebastian Renelt +11 more
doaj +1 more source
Gut as viral reservoir: lessons from gut viromes, HIV and COVID-19
Gut, 2021 The gut microbiota is composed of bacteria, fungi and viruses.1–3 While the presence and composition of the bacteriome have been extensively studied in recent years, the ‘dark matter’ of microbiomes including viruses (viral microbiome or virome) remains ...
M. Neurath, K. Überla, S. Ng
semanticscholar +1 more source
Microglial HIV-1 Expression: Role in HIV-1 Associated Neurocognitive Disorders
Viruses, 2021 The persistence of HIV-1 viral reservoirs in the brain, despite treatment with combination antiretroviral therapy (cART), remains a critical roadblock for the development of a novel cure strategy for HIV-1.
Hailong Li +4 more
doaj +1 more source
Monocytes and Macrophages as Viral Targets and Reservoirs [PDF]
International Journal of Molecular Sciences, 2018 Viruses manipulate cell biology to utilize monocytes/macrophages as vessels for dissemination, long-term persistence within tissues and virus replication. Viruses enter cells through endocytosis, phagocytosis, macropinocytosis or membrane fusion. These processes play important roles in the mechanisms contributing to the pathogenesis of these agents and
Nikitina, Ekaterina +3 more
openaire +2 more sources
Southern African Journal of HIV Medicine, 2020 Background: While combined antiretroviral therapy (cART) allows near-normal life expectancy for people living with human immunodeficiency virus (HIV), it is unable to cure the infection and so life long treatment is required.
Alexander M.L. Hayes
doaj +1 more source
Do ‘special’ viral reservoirs exist? [PDF]
Nature Reviews Microbiology, 2020 A recent analysis concludes that there is little evidence to support the notion that reservoir host affects the propensity for a virus to infect humans.
openaire +2 more sources
Qualitative and quantitative HIV antibodies and viral reservoir size characterization in vertically infected children with virological suppression [PDF]
Journal of Antimicrobial Chemotherapy, 2016 International audienceBackground: Absence of detectable viraemia after treatment cessation in some vertically HIV-infected (VHIV) children suggests that early initiation of HAART could lead to functional cure.Objectives: We described the factors ...
J. Brice +15 more
semanticscholar +2 more sources
HCMV Antivirals and Strategies to Target the Latent Reservoir [PDF]
, 2021 Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. In healthy people, primary infection is generally asymptomatic, and the virus can go on to establish lifelong latency in cells of the myeloid lineage.
Mark R. Wills +2 more
core +1 more source
Lnc(ing)RNAs to the “shock and kill” strategy for HIV-1 cure
Molecular Therapy: Nucleic Acids, 2021 The advent of antiretroviral therapy almost 25 years ago has transformed HIV-1 infection into a manageable chronic condition, albeit still incurable. The inability of the treatment regimen to eliminate latently infected cells that harbor the virus in an ...
Saikat Boliar, David G. Russell
doaj +1 more source
Residual inflammation and viral reservoirs [PDF]
Current Opinion in HIV and AIDS, 2016 HIV persists in cellular and anatomical reservoirs during antiretroviral therapy (ART). Viral persistence is ensured by a variety of mechanisms including ongoing viral replication and proliferation of latently infected cells. In this review, we summarize recent findings establishing a link between the unresolved levels of inflammation observed in ...
Marta, Massanella +2 more
openaire +2 more sources