Results 41 to 50 of about 84,140 (293)

Cellular Reservoirs of HIV-1 and their Role in Viral Persistence [PDF]

Current HIV Research, 2008
A major obstacle in human immunodeficiency virus type 1 (HIV-1) eradication is the ability of the virus to remain latent in a subpopulation of the cells it infects. Latently infected cells can escape the viral immune response and persist for long periods of time, despite the presence of successful highly active antiretroviral therapy (HAART). Given the
Aikaterini, Alexaki, Yujie, Liu, Brian, Wigdahl   +2 more
openaire   +2 more sources

The influence of bat ecology on viral diversity and reservoir status [PDF]

Ecology and Evolution, 2020
AbstractRepeated emergence of zoonotic viruses from bat reservoirs into human populations demands predictive approaches to preemptively identify virus‐carrying bat species. Here, we use machine learning to examine drivers of viral diversity in bats, determine whether those drivers depend on viral genome type, and predict undetected viral carriers.
Cylita Guy, John M. Ratcliffe, Nicole Mideo   +2 more
openaire   +3 more sources

Optimising predictive models to prioritise viral discovery in zoonotic reservoirs [PDF]

The Lancet Microbe, 2022
Despite the global investment in One Health disease surveillance, it remains difficult and costly to identify and monitor the wildlife reservoirs of novel zoonotic viruses. Statistical models can guide sampling target prioritisation, but the predictions from any given model might be highly uncertain; moreover, systematic model validation is rare, and ...
Becker, Daniel J., Albery, Gregory F., Sjodin, Anna R., Poisot, Timothée, Bergner, Laura M., Chen, Binqi, Cohen, Lily E., Dallas, Tad A., Eskew, Evan A., Fagre, Anna C., Farrell, Maxwell J., Guth, Sarah, Han, Barbara A., Simmons, Nancy B., Stock, Michiel, Teeling, Emma C., Carlson, Colin J.   +16 more
openaire   +5 more sources

Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir

eLife, 2018
Human dengue viruses emerged from primate reservoirs, yet paradoxically dengue does not reach high titers in primate models. This presents a unique opportunity to examine the genetics of spillover versus reservoir hosts.
Alex C Stabell, Nicholas R Meyerson, Rebekah C Gullberg, Alison R Gilchrist, Kristofor J Webb, William M Old, Rushika Perera, Sara L Sawyer   +7 more
doaj   +1 more source

Bats and birds as viral reservoirs: A physiological and ecological perspective

Science of The Total Environment, 2021
(Uploaded by Plazi for the Bat Literature Project) The birds (class Aves) and bats (order Chiroptera, class Mammalia) are well known natural reservoirs of a diverse range of viruses, including some zoonoses. The only extant volant vertebrates, bats and birds have undergone dramatic adaptive radiations that have allowed them to occupy diverse ecological
Nabi, Ghulam, Wang, Yang, Lü, Liang, Jiang, Chuan, Ahmad, Shahid, Wu, Yuefeng, Li, Dongming   +6 more
openaire   +2 more sources

Rapid Seeding of the Viral Reservoir Prior to SIV Viremia in Rhesus Monkeys [PDF]

, 2015
The viral reservoir represents a critical challenge facing HIV-1 eradication strategies1–5. However, it remains unclear when and where the viral reservoir is seeded during acute infection and the extent to which it is susceptible to early antiretroviral ...
Blackmore, Stephen, Smith, Kaitlin M., Barouch, Dan, Hill, Alison L., Kim, Jerome H., Rosenbloom, Daniel I.S., Liu, Jinyan, Geleziunas, Romas, Robb, Merlin L., Brinkman, Amanda L., Mathew, Sheeba I., Shetty, Mayuri, Peter, Lauren E., Hesselgesser, Joseph, Borducchi, Erica N., Smith, Jeffrey Y., Cabral, Crystal, Whitney, James, Shields, Jennifer, Michael, Nelson L., Hattersley, Jillian, Penaloza-MacMaster, Pablo, Sanisetty, Srisowmya, Lewis, Mark G., Parenteau, Lily, Li, Bei   +25 more
core   +1 more source

Forging a Functional Cure for HIV: Transcription Regulators and Inhibitors

Viruses, 2022
Current antiretroviral therapy (ART) increases the survival of HIV-infected individuals, yet it is not curative. The major barrier to finding a definitive cure for HIV is our inability to identify and eliminate long-lived cells containing the dormant ...
Sonia Mediouni, Shuang Lyu, Susan M. Schader, Susana T. Valente   +3 more
doaj   +1 more source

Targeting viral reservoirs: ability of antiretroviral therapy to stop viral replication [PDF]

Current Opinion in HIV and AIDS, 2011
HIV infection is controlled but not cured by combination antiretroviral therapy. HIV may persist for a number of reasons, including ongoing cycles of HIV infection or viral persistence as latent, or HIV replication in long-lived cells containing HIV proviruses. Therapeutic consequences of these alternative mechanisms are significant and distinct.
openaire   +2 more sources

HCMV Antivirals and Strategies to Target the Latent Reservoir

, 2021
Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. In healthy people, primary infection is generally asymptomatic, and the virus can go on to establish lifelong latency in cells of the myeloid lineage.
Mark R. Wills, John H. Sinclair, Marianne R. Perera   +2 more
core   +1 more source

Sustained antiviral response against in vitro HIV-1 infection in peripheral blood mononuclear cells from people with chronic myeloid leukemia treated with ponatinib

Frontiers in Pharmacology
HIV-1 infection cannot be cured due to long-lived viral reservoirs formed by latently infected CD4+ T cells. “Shock and Kill” strategy has been considered to eliminate the viral reservoir and achieve a functional cure but the stimulation of cytotoxic ...
Mario Manzanares, Mario Manzanares, Fernando Ramos-Martín, Sara Rodríguez-Mora, Sara Rodríguez-Mora, Guiomar Casado-Fernández, Guiomar Casado-Fernández, Clara Sánchez-Menéndez, Clara Sánchez-Menéndez, Clara Sánchez-Menéndez, Alicia Simón-Rueda, Alicia Simón-Rueda, Elena Mateos, Elena Mateos, Miguel Cervero, Miguel Cervero, Adam M. Spivak, Vicente Planelles, Montserrat Torres, Montserrat Torres, Valentín García-Gutiérrez, Mayte Coiras, Mayte Coiras   +22 more
doaj   +1 more source