Results 61 to 70 of about 1,595,225 (317)

Redefining the Viral Reservoirs that Prevent HIV-1 Eradication [PDF]

Immunity, 2012
This Perspective proposes definitions for key terms in the field of HIV-1 latency and eradication. In the context of eradication, a reservoir is a cell type that allows persistence of replication-competent HIV-1 on a timescale of years in patients on optimal antiretroviral therapy. Reservoirs act as a barrier to eradication in the patient population in
Eisele, Evelyn, Siliciano, Robert F.
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Effect of Persistent Low-Level Activation of the Latent Reservoir on the Latent Reservoir and on Plasma Viral Load [PDF]

, 2013
When there is no ongoing viral replication (ɛ = 1) and the rate of bystander proliferation of the latent reservoir is equal to the minimum activation rate (r = amin), i.e., at the bifurcation condition.(A) Latent reservoir.(B) Plasma viral load.
Alan S Perelson (379607), Hwijin Kim (379606)   +1 more
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Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays [PDF]

, 2022
Significant advances in the field of HIV-1 therapeutics to achieve antiretroviral treatment (ART)-free remission and cure for persons living with HIV-1 are being made with the advent of broadly neutralizing antibodies and very early ART in perinatal ...
Yufeng Liu, Persaud, Deborah, Adit Dhummakupt, Liu, Yufeng, Dhummakupt, Adit, Priya Khetan, Deborah Persaud, Khetan, Priya   +7 more
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Extracellular Vesicles as a New Promising Therapy in HIV Infection

Frontiers in Immunology, 2022
Combination antiretroviral therapy (cART) effectively blocks HIV replication but cannot completely eliminate HIV from the body mainly due to establishment of a viral reservoir.
Maria A. Navarrete-Muñoz, Maria A. Navarrete-Muñoz, Maria A. Navarrete-Muñoz, Carlos Llorens, José M. Benito, José M. Benito, Norma Rallón, Norma Rallón   +7 more
doaj   +1 more source

Cellular Reservoirs of HIV-1 and their Role in Viral Persistence [PDF]

Current HIV Research, 2008
A major obstacle in human immunodeficiency virus type 1 (HIV-1) eradication is the ability of the virus to remain latent in a subpopulation of the cells it infects. Latently infected cells can escape the viral immune response and persist for long periods of time, despite the presence of successful highly active antiretroviral therapy (HAART). Given the
Aikaterini, Alexaki, Yujie, Liu, Brian, Wigdahl   +2 more
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The influence of bat ecology on viral diversity and reservoir status [PDF]

Ecology and Evolution, 2020
AbstractRepeated emergence of zoonotic viruses from bat reservoirs into human populations demands predictive approaches to preemptively identify virus‐carrying bat species. Here, we use machine learning to examine drivers of viral diversity in bats, determine whether those drivers depend on viral genome type, and predict undetected viral carriers.
Cylita Guy, John M. Ratcliffe, Nicole Mideo   +2 more
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Rapid Seeding of the Viral Reservoir Prior to SIV Viremia in Rhesus Monkeys [PDF]

, 2015
The viral reservoir represents a critical challenge facing HIV-1 eradication strategies1–5. However, it remains unclear when and where the viral reservoir is seeded during acute infection and the extent to which it is susceptible to early antiretroviral ...
Blackmore, Stephen, Smith, Kaitlin M., Barouch, Dan, Hill, Alison L., Kim, Jerome H., Rosenbloom, Daniel I.S., Liu, Jinyan, Geleziunas, Romas, Robb, Merlin L., Brinkman, Amanda L., Mathew, Sheeba I., Shetty, Mayuri, Peter, Lauren E., Hesselgesser, Joseph, Borducchi, Erica N., Smith, Jeffrey Y., Cabral, Crystal, Whitney, James, Shields, Jennifer, Michael, Nelson L., Hattersley, Jillian, Penaloza-MacMaster, Pablo, Sanisetty, Srisowmya, Lewis, Mark G., Parenteau, Lily, Li, Bei   +25 more
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Targeting viral reservoirs: ability of antiretroviral therapy to stop viral replication [PDF]

Current Opinion in HIV and AIDS, 2011
HIV infection is controlled but not cured by combination antiretroviral therapy. HIV may persist for a number of reasons, including ongoing cycles of HIV infection or viral persistence as latent, or HIV replication in long-lived cells containing HIV proviruses. Therapeutic consequences of these alternative mechanisms are significant and distinct.
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Bats and birds as viral reservoirs: A physiological and ecological perspective

Science of The Total Environment, 2021
(Uploaded by Plazi for the Bat Literature Project) The birds (class Aves) and bats (order Chiroptera, class Mammalia) are well known natural reservoirs of a diverse range of viruses, including some zoonoses. The only extant volant vertebrates, bats and birds have undergone dramatic adaptive radiations that have allowed them to occupy diverse ecological
Nabi, Ghulam, Wang, Yang, Lü, Liang, Jiang, Chuan, Ahmad, Shahid, Wu, Yuefeng, Li, Dongming   +6 more
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Sustained antiviral response against in vitro HIV-1 infection in peripheral blood mononuclear cells from people with chronic myeloid leukemia treated with ponatinib

Frontiers in Pharmacology
HIV-1 infection cannot be cured due to long-lived viral reservoirs formed by latently infected CD4+ T cells. “Shock and Kill” strategy has been considered to eliminate the viral reservoir and achieve a functional cure but the stimulation of cytotoxic ...
Mario Manzanares, Mario Manzanares, Fernando Ramos-Martín, Sara Rodríguez-Mora, Sara Rodríguez-Mora, Guiomar Casado-Fernández, Guiomar Casado-Fernández, Clara Sánchez-Menéndez, Clara Sánchez-Menéndez, Clara Sánchez-Menéndez, Alicia Simón-Rueda, Alicia Simón-Rueda, Elena Mateos, Elena Mateos, Miguel Cervero, Miguel Cervero, Adam M. Spivak, Vicente Planelles, Montserrat Torres, Montserrat Torres, Valentín García-Gutiérrez, Mayte Coiras, Mayte Coiras   +22 more
doaj   +1 more source