Results 71 to 80 of about 84,140 (293)

Nanoengineered Binetworks in Multifunctional Anionic Block Polymer Mesoblends for Improved Mechanical Properties

Advanced Functional Materials, EarlyView.
Mesoblends consist of a nanostructured polymer into which a second polymer is imbibed with a selective solvent. In this work, a solvent‐templatable pentablock terpolymer possessing a sulfonated midblock is modified with a hydrophilic polymer that is photocrosslinked in situ, yielding a hierarchical binetwork.
Kacie M. Wells, Ivan Kuzmenko, Reza A. Ghiladi, Richard J. Spontak   +3 more
wiley   +1 more source

Pre-existing cell populations with cytotoxic activity against SARS-CoV-2 in people with HIV and normal CD4/CD8 ratio previously unexposed to the virus

Frontiers in Immunology
IntroductionHIV-1 infection may produce a detrimental effect on the immune response. Early start of antiretroviral therapy (ART) is recommended to preserve the integrity of the immune system. In fact, people with HIV (PWH) and normal CD4/CD8 ratio appear
Guiomar Casado-Fernández, Guiomar Casado-Fernández, Juan Cantón, Juan Cantón, Laura Nasarre, Fernando Ramos-Martín, Mario Manzanares, Mario Manzanares, Clara Sánchez-Menéndez, Clara Sánchez-Menéndez, Clara Sánchez-Menéndez, Daniel Fuertes, Elena Mateos, Elena Mateos, María Aranzazu Murciano-Antón, María Aranzazu Murciano-Antón, Mayte Pérez-Olmeda, Mayte Pérez-Olmeda, Miguel Cervero, Miguel Cervero, Montserrat Torres, Montserrat Torres, Rafael Rodríguez-Rosado, Rafael Rodríguez-Rosado, Mayte Coiras, Mayte Coiras   +25 more
doaj   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Effect of Persistent Low-Level Activation of the Latent Reservoir on the Latent Reservoir and on Plasma Viral Load

, 2013
When there is no ongoing viral replication (ɛ = 1) and the rate of bystander proliferation of the latent reservoir is equal to the minimum activation rate (r = amin), i.e., at the bifurcation condition.(A) Latent reservoir.(B) Plasma viral load.
Alan S Perelson (379607), Hwijin Kim (379606)   +1 more
core   +1 more source

Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays

, 2022
Significant advances in the field of HIV-1 therapeutics to achieve antiretroviral treatment (ART)-free remission and cure for persons living with HIV-1 are being made with the advent of broadly neutralizing antibodies and very early ART in perinatal ...
Yufeng Liu, Persaud, Deborah, Adit Dhummakupt, Liu, Yufeng, Dhummakupt, Adit, Priya Khetan, Deborah Persaud, Khetan, Priya   +7 more
core   +1 more source

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Advanced Materials, EarlyView.
This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao   +10 more
wiley   +1 more source

The active human immunodeficiency virus reservoir during antiretroviral therapy: emerging players in viral persistence [PDF]

, 2021
Marcadors cel·lulars; Virus de la immunodeficiència humana; Persistència viralMarcadores celulares; Virus de la inmunodeficiencia humana; Persistencia viralCell markers; Human immunodeficiency virus; Viral persistencePurpose of review To discuss the ...
Astorga Gamaza, Antonio, Maria J. Buzon, Buzón Gómez, María José, Antonio Astorga-Gamaza   +3 more
core   +1 more source

Deep Thought on the HIV Cured Cases: Where Have We Been and What Lies Ahead?

Biomolecules
Antiretroviral therapy (ART) can effectively suppress the replication of human immunodeficiency virus (HIV), but it cannot completely eradicate the virus. The persistent existence of the HIV reservoir is a major obstacle in the quest for a cure. To date,
Qing Xiao, Sanxiu He, Chaoyu Wang, Yixing Zhou, Chensi Zeng, Jun Liu, Tingting Liu, Tingting Li, Xi Quan, Linyue Wang, Liuyue Zhai, Yi Liu, Jun Li, Xiaomei Zhang, Yao Liu   +14 more
doaj   +1 more source

Transducers Across Scales and Frequencies: A System‐Level Framework for Multiphysics Integration and Co‐Design

Advanced Materials Technologies, EarlyView.
Transducers convert physical signals into electrical and optical representations, yet each mechanism is bounded by intrinsic trade‐offs across bandwidth, sensitivity, speed, and energy. This review maps transduction mechanisms across physical scale and frequency, showing how heterogeneous integration and multiphysics co‐design transform isolated ...
Aolei Xu, Mengyao Xiao, Zhouli Sui, Yinpeng Wang, Daoye Zheng, Yuxin Liu, Luwei Wang, Huajun Liu, Chengkuo Lee   +8 more
wiley   +1 more source

Peripheral immune responses to filoviruses in a reservoir versus spillover hosts reveal transcriptional correlates of disease

Frontiers in Immunology
Several filoviruses, including Marburg virus (MARV), cause severe disease in humans and nonhuman primates (NHPs). However, the Egyptian rousette bat (ERB, Rousettus aegyptiacus), the only known MARV reservoir, shows no overt illness upon natural or ...
Jonathan C. Guito, Catherine E. Arnold, Catherine E. Arnold, Amy J. Schuh, Brian R. Amman, Tara K. Sealy, Jessica R. Spengler, Jessica R. Harmon, Joann D. Coleman-McCray, Mariano Sanchez-Lockhart, Gustavo F. Palacios, Jonathan S. Towner, Joseph B. Prescott, Joseph B. Prescott   +13 more
doaj   +1 more source