Results 71 to 80 of about 1,595,225 (317)

Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir

eLife, 2018
Human dengue viruses emerged from primate reservoirs, yet paradoxically dengue does not reach high titers in primate models. This presents a unique opportunity to examine the genetics of spillover versus reservoir hosts.
Alex C Stabell, Nicholas R Meyerson, Rebekah C Gullberg, Alison R Gilchrist, Kristofor J Webb, William M Old, Rushika Perera, Sara L Sawyer   +7 more
doaj   +1 more source

Comparative HIV-1 Proviral Dynamics in Two Individuals That Maintained Viral Replication Control with or without Antiretroviral Therapy following Superinfection [PDF]

, 2022
The analysis of the HIV-1 proviral dynamics after superinfection in the context of both natural and antiretroviral therapy (ART)-mediated suppression could yield unique insights into understanding the persistence of viral variants that seeded the ...
Suwellen Sardinha Dias de Azevedo, Beatriz Grinsztejn, Côrtes, Fernanda H., Larissa M. Villela, de Azevedo, Suwellen Sardinha Dias, Bello, Gonzalo, Fernanda H. Côrtes, Valdilea G. Veloso, Morgado, Mariza G., Gonzalo Bello, Grinsztejn, Beatriz, Veloso, Valdilea G., Mariza G. Morgado, Hoagland, Brenda, Brenda Hoagland, Villela, Larissa M.   +15 more
core   +1 more source

Forging a Functional Cure for HIV: Transcription Regulators and Inhibitors

Viruses, 2022
Current antiretroviral therapy (ART) increases the survival of HIV-infected individuals, yet it is not curative. The major barrier to finding a definitive cure for HIV is our inability to identify and eliminate long-lived cells containing the dormant ...
Sonia Mediouni, Shuang Lyu, Susan M. Schader, Susana T. Valente   +3 more
doaj   +1 more source

TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy

Science Translational Medicine, 2018
SIV-infected rhesus macaques on antiretroviral therapy experienced a reduction in the SIV reservoir after treatment with TLR7 agonists. Emptying the reservoir Antiretroviral therapy can halt HIV-1 replication but cannot clear the hidden reservoirs of ...
So-Yon Lim, C. Osuna, P. Hraber, J. Hesselgesser, Jeffrey M. Gerold, Tiffany L. Barnes, Srisowmya Sanisetty, M. Seaman, M. Lewis, R. Geleziunas, Michael D. Miller, T. Cihlář, William A. Lee, A. Hill, J. Whitney   +14 more
semanticscholar   +1 more source

Impacts of HIV Cure Interventions on Viral Reservoirs in Tissues [PDF]

Frontiers in Microbiology, 2019
HIV reservoirs persist in infected individuals despite combination antiretroviral therapy and can be identified in secondary lymphoid tissues, in intestinal tissues, in the central nervous system as well as in blood. Clinical trials have begun to explore effects of small molecule interventions to perturb the latent viral infection, but only limited ...
Paul W. Denton, Ole S. Søgaard, Ole S. Søgaard, Martin Tolstrup, Martin Tolstrup   +4 more
openaire   +3 more sources

Viral genomic features predict orthopoxvirus reservoir hosts

Communications Biology, 2023
Abstract Orthopoxviruses (OPVs), including the causative agents of smallpox and mpox have led to devastating outbreaks in human populations worldwide. However, the discontinuation of smallpox vaccination, which also provides cross-protection against related OPVs, has diminished global immunity to OPVs more broadly.
Katie K. Tseng, Heather Koehler, Daniel J. Becker, Rory Gibb, Colin J. Carlson, Maria del Pilar Fernandez, Stephanie N. Seifert   +6 more
openaire   +4 more sources

CCR5 gene editing and HIV immunotherapy: current understandings, challenges, and future directions

Frontiers in Immunology
Human immunodeficiency virus (HIV) infection remains a major global public health challenge. Although highly active antiretroviral therapy (HAART or ART) can effectively control viral replication, it fails to eradicate latent viral reservoirs and poses ...
Jia-Wen Wang, Jia-Hui Liu, Jian-Jun Xun
doaj   +1 more source

Detectable HIV-1 in semen in individuals with very low blood viral loads

Virology Journal, 2020
Background Several reports indicate that a portion (5–10%) of men living with HIV-1 intermittently shed HIV-1 RNA into seminal plasma while on long term effective antiretroviral therapy (ART).
Samuel Mundia Kariuki, Philippe Selhorst, Jennifer Norman, Karen Cohen, Kevin Rebe, Carolyn Williamson, Jeffrey R. Dorfman   +6 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells

Nature Communications, 2017
HIV-1 insertions targeting BACH2 or MLK2 are enriched and persist for decades in hematopoietic cells from patients under combination antiretroviral therapy.
D. Cesana, F. R. Santoni de Sio, L. Rudilosso, P. Gallina, A. Calabria, S. Beretta, I. Merelli, E. Bruzzesi, L. Passerini, S. Nozza, E. Vicenzi, G. Poli, S. Gregori, G. Tambussi, E. Montini   +14 more
semanticscholar   +1 more source