Results 81 to 90 of about 1,595,225 (317)
Reservoir differences across HIV-1 subtypes: a systematic review to guide cure research
Frontiers in ImmunologyIntroductionDespite effective antiretroviral therapy, HIV-1 persists as a viral reservoir and remains a major barrier to a durable cure. Reservoir size and dynamics are central determinants of the success of cure strategies.
Myrthe S. Willemsen +22 more
doaj +1 more source
Viral zoonotic risk is homogenous among taxonomic orders of mammalian and avian reservoir hosts
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Identifying whether novel human viruses disproportionately originate from certain animal groups could inform risk-based allocations of research and surveillance effort. Whether such “special reservoirs” exist remains controversial.
Nardus Mollentze, D. Streicker
semanticscholar +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Frontiers in ImmunologyBackgroundPeople living with chronic HIV (PLWH) show immune dysfunction, despite viral suppression and normal CD4 recovery, particularly those with low CD4/CD8 ratios.
Vanesa Garrido-Rodríguez +28 more
doaj +1 more source
Frontiers in Immunology, 2017 Human immunodeficiency virus (HIV) infects millions of people worldwide, and new cases continue to emerge. Once infected, the virus cannot be cleared by the immune system and causes acquired immunodeficiency syndrome.
Yew Ann Leong +3 more
doaj +1 more source
Obesity, 2020 Coronavirus disease 2019 (COVID‐19), the worst pandemic in more than a century, has claimed >125,000 lives worldwide to date. Emerging predictors for poor outcomes include advanced age, male sex, preexisting cardiovascular disease, and risk factors ...
P. Ryan, N. Caplice
semanticscholar +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
The Role of Viral Systems in Nutrient Cycling [PDF]
, 2011 The Te Arawa/Rotorua lakes located in the central North Island of New Zealand have significant cultural, historic, social and economic value. Anthropogenic changes in land use have led to a decline in water quality in some lakes.
Dennis, Marie Ann
core
Journal of Virus Eradication, 2018 Objectives: The interaction between HIV and the immune system gives rise to a complex dynamical system. We therefore investigate whether delayed viral rebound after antiretroviral therapy (ART) interruption (ATI) may be due to an individual's viral ...
John M. Murray
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao +5 more
wiley +1 more source