Results 81 to 90 of about 84,140 (293)

Inducible HIV-1 Reservoir Quantification: Clinical Relevance, Applications and Advancements of TILDA

Frontiers in Microbiology, 2021
The presence of a stable HIV-1 reservoir persisting over time despite effective antiretroviral suppression therapy precludes a cure for HIV-1. Characterizing and quantifying this residual reservoir is considered an essential prerequisite to develop and ...
Cynthia Lungu, Riddhima Banga, Rob A. Gruters, Francesco A. Procopio   +3 more
doaj   +1 more source

A Proof‐of‐Concept Assessment of a Novel Wearable Eyelid Muscle Device: A Pre‐Clinical Animal Cadaver Study for Eyelid Closure Restoration

Advanced Robotics Research, EarlyView.
This article introduces a soft wearable eyelid sling device incorporating a hydraulic soft artificial muscle (SAM) for achieving complete closure of an eyelid. The SAM is driven by a cam mechanism that provides a displacement profile closely matched with those of a healthy eyelid.
Patrick Pruscino, Phuoc Thien Phan, James Davies, Bibhu Sharma, Tianruo Guo, Chi Cong Nguyen, Nigel H. Lovell, Thanh Nho Do   +7 more
wiley   +1 more source

HIV-1 variants are archived throughout infection and persist in the reservoir.

PLoS Pathogens, 2020
The HIV-1 reservoir consists of latently infected cells that persist despite antiretroviral therapy (ART). Elucidating the proviral genetic composition of the reservoir, particularly in the context of pre-therapy viral diversity, is therefore important ...
Kelsie Brooks, Bradley R Jones, Dario A Dilernia, Daniel J Wilkins, Daniel T Claiborne, Samantha McInally, Jill Gilmour, William Kilembe, Jeffrey B Joy, Susan A Allen, Zabrina L Brumme, Eric Hunter   +11 more
doaj   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

The Abundance and Behavior of Viruses in Ancient Seawater and Modern Iron-rich Environments [PDF]

, 2011
The proclivity of silica for ferric hydroxide sorption sites allows for an Archean iron cycle involving iron-silica co-precipitation and deposition of banded iron formations (BIF).
Liu, Hanna Ken-Yuin
core   +1 more source

Comparative HIV-1 Proviral Dynamics in Two Individuals That Maintained Viral Replication Control with or without Antiretroviral Therapy following Superinfection

, 2022
The analysis of the HIV-1 proviral dynamics after superinfection in the context of both natural and antiretroviral therapy (ART)-mediated suppression could yield unique insights into understanding the persistence of viral variants that seeded the ...
Suwellen Sardinha Dias de Azevedo, Beatriz Grinsztejn, Côrtes, Fernanda H., Larissa M. Villela, de Azevedo, Suwellen Sardinha Dias, Bello, Gonzalo, Fernanda H. Côrtes, Valdilea G. Veloso, Morgado, Mariza G., Gonzalo Bello, Grinsztejn, Beatriz, Veloso, Valdilea G., Mariza G. Morgado, Hoagland, Brenda, Brenda Hoagland, Villela, Larissa M.   +15 more
core   +1 more source

Neutralizing the threat: harnessing broadly neutralizing antibodies against HIV-1 for treatment and prevention

Microbial Cell
Broadly neutralizing antibodies (bnAbs) targeting the human immunodeficiency virus-1 (HIV-1) have played a crucial role in elucidating and characterizing neutralization-sensitive sites on the HIV-1 envelope spike and in informing vaccine development ...
Juan C Becerra, Lauren Hitchcock, Khoa Vu, Johannes S Gach   +3 more
doaj   +1 more source

A stochastic model of latently infected cell reactivation and viral blip generation in treated HIV patients.

PLoS Computational Biology, 2011
Motivated by viral persistence in HIV+ patients on long-term anti-retroviral treatment (ART), we present a stochastic model of HIV viral dynamics in the blood stream.
Jessica M Conway, Daniel Coombs
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Effect of the Latent Reservoir on the Evolution of HIV at the Within- and Between-Host Levels.

PLoS Computational Biology, 2017
The existence of long-lived reservoirs of latently infected CD4+ T cells is the major barrier to curing HIV, and has been extensively studied in this light.
Hilje M Doekes, Christophe Fraser, Katrina A Lythgoe   +2 more
doaj   +1 more source