Results 101 to 110 of about 956,535 (302)

The role of Nef in the long-term persistence of the replication-competent HIV reservoir in South African women

Journal of Virology
HIV-1 Nef mediates immune evasion and viral pathogenesis in part through the downregulation of cell surface cluster of differentiation 4 (CD4) and major histocompatibility complex class I (MHC-I) on infected cells.
Sherazaan D. Ismail, Shorok Sebaa, Bianca Abrahams, Martha C. Nason, Mitchell J. Mumby, Jimmy D. Dikeakos, Sarah B. Joseph, Matthew Moeser, Ronald Swanstrom, Nigel Garrett, Carolyn Williamson, Thomas C. Quinn, Melissa-Rose Abrahams, Andrew D. Redd   +13 more
doaj   +1 more source

Decoding Viral Transmission Dynamics in Structured Populations Using a Microfluidic Herd‐Immunity‐on‐a‐Chip Platform

Advanced Science, EarlyView.
A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang, Narina Jung, Min‐Hyeok Kim, Wanyoung Lim, Zhenzhong Chen, Byung Mook Weon, Sungsu Park   +6 more
wiley   +1 more source

Viral hepatitis surveillance United States, 2018 [PDF]

Viral Hepatitis Surveillance \u2014 United States, 2018 is published by the Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC), U.S.

core   +2 more sources

Myeloid and CD4 T Cells Comprise the Latent Reservoir in Antiretroviral Therapy-Suppressed SIVmac251-Infected Macaques

mBio, 2019
Human immunodeficiency virus (HIV) eradication or long-term suppression in the absence of antiretroviral therapy (ART) requires an understanding of all viral reservoirs that could contribute to viral rebound after ART interruption. CD4 T cells (CD4s) are
Celina M. Abreu, Rebecca T. Veenhuis, Claudia R. Avalos, Shelby Graham, Daymond R. Parrilla, Edna A. Ferreira, Suzanne E. Queen, Erin N. Shirk, Brandon T. Bullock, Ming Li, Kelly A. Metcalf Pate, Sarah E. Beck, Lisa M. Mangus, Joseph L. Mankowski, Feilim Mac Gabhann, Shelby L. O’Connor, Lucio Gama, Janice E. Clements   +17 more
doaj   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

In-host modeling of Tfh–Tfr–fCD8+ T cell dynamics on HIV reservoir persistence

Frontiers in Applied Mathematics and Statistics
HIV persistence within germinal centers is driven by complex interactions among T follicular helper (Tfh), T follicular regulatory (Tfr), and follicular CD8+ (fCD8+) T cells. Yet, the mechanisms sustaining the viral reservoir remain poorly understood. We
Faraimunashe Chirove, Koffi Messan Agbavon   +1 more
doaj   +1 more source

Division of Viral Hepatitis 2025 strategic plan [PDF]

DVH\u2019s 2025 Strategic Plan articulates DVH\u2019s vision, mission, core values, and goals. Each goal is further defined by specific and time-bound outcome measures and supporting objectives and associated strategies.

core  

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Seoul orthohantavirus evades innate immune activation by reservoir endothelial cells.

PLoS Pathogens
Pathogenic hantaviruses are maintained world-wide within wild, asymptomatic rodent reservoir hosts, with increasingly frequent human spillover infections resulting in severe hemorrhagic fever or cardio-pulmonary disease.
Stefan D Klimaj, Autumn LaPointe, Kimberly Martinez, Eduardo Hernandez Acosta, Alison M Kell   +4 more
doaj   +1 more source

Reservoir characterization using support vector machines [PDF]

, 2005
Reservoir characterization especially well log data analysis plays an important role in petroleum exploration. This is the process used to identify the potential for oil production at a given source.
Wong, K.W., Fung, C.C., Gedeon, T., Ong, Y.S.   +3 more
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