Results 101 to 110 of about 1,595,225 (317)

The active human immunodeficiency virus reservoir during antiretroviral therapy: emerging players in viral persistence [PDF]

, 2021
Marcadors cel·lulars; Virus de la immunodeficiència humana; Persistència viralMarcadores celulares; Virus de la inmunodeficiencia humana; Persistencia viralCell markers; Human immunodeficiency virus; Viral persistencePurpose of review To discuss the ...
Astorga Gamaza, Antonio, Maria J. Buzon, Buzón Gómez, María José, Antonio Astorga-Gamaza   +3 more
core   +1 more source

The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infection [PDF]

Journal of Leukocyte Biology, 2003
AbstractCellular viral reservoirs and anatomic sanctuary sites allow continuing HIV-1 replication in patients with suppressed plasma viremia who are receiving highly active antiretroviral therapy and prevent eradication of HIV-1 by these regimens.
Suzanne, Crowe, Tuofu, Zhu, William A, Muller   +2 more
openaire   +2 more sources

A Modular Liver–Microbial Microfluidic Platform to Evaluate Therapeutic and Adverse Effects of Microbial Metabolites

Advanced Healthcare Materials, EarlyView.
This study introduces a modular microfluidic platform that connects liver cells with live microbes to mimic key aspects of the gut–liver interaction in steatosis. Using this system, both microbial metabolites and live bacteria significantly reduced fat accumulation in liver cells, but live microbes triggered inflammation and broader metabolic changes ...
Hsih‐Yin Tan, In Young Hwang, Nanthini Jayabalan, Hui Ling Lee, Louis Jun Ye Ong, Chwee Teck Lim, Matthew Wook Chang, Yi‐Chin Toh   +7 more
wiley   +1 more source

Biodiversity and distribution of polar freshwater DNA viruses [PDF]

, 2015
Viruses constitute the most abundant biological entities and a large reservoir of genetic diversity on Earth. Despite the recent surge in their study, our knowledge on their actual biodiversity and distribution remains sparse.
López-Bueno, Alberto, Pearce, David, Pearce, David A., Alcamí, Antonio, Aguirre de Cárcer, Daniel   +4 more
core   +1 more source

Immune response dynamics of SARS-CoV-2 vaccination in chronic lymphocytic leukemia individuals: a descriptive analysis

Frontiers in Immunology
Chronic lymphocytic leukaemia (CLL) is a lymphoproliferative disorder of abnormal B-lymphocytes. Due to immune deregulation and therapy-related factors, CLL individuals face increased infection risks, making vaccination a priority.
Clara Sánchez-Menéndez, Clara Sánchez-Menéndez, Clara Sánchez-Menéndez, Alejandro Zurdo, Magdalena Corona, Elena Mateos de la Morenas, Elena Mateos de la Morenas, Sara Rodríguez-Mora, Sara Rodríguez-Mora, Guiomar Casado, Guiomar Casado, Javier García-Pérez, Javier García-Pérez, Mayte Pérez-Olmeda, Mayte Pérez-Olmeda, Susana Domínguez, María Aránzazu Murciano-Antón, Javier López-Jiménez, Valentín García-Gutiérrez, Mayte Coiras, Mayte Coiras, Montserrat Torres, Montserrat Torres   +22 more
doaj   +1 more source

Targeting Macrophage Dysregulation for Viral Infections: Novel Targets for Immunomodulators

Frontiers in Immunology, 2021
A major barrier to human immunodeficiency virus (HIV-1) cure is the latent viral reservoir, which persists despite antiretroviral therapy (ART), including across the non-dividing myeloid reservoir which is found systemically in sanctuary sites across ...
Monica D. Reece, Ruby R. Taylor, Colin Song, Christina Gavegnano   +3 more
doaj   +1 more source

Tenofovir Disoproxil Fumarate Fails to Prevent HIV Acquisition or the Establishment of a Viral Reservoir: Two Case Reports

Infectious Disease and Therapy, 2016
The use of antiretrovirals as pre-exposure prophylaxis (PrEP) is highly efficacious in HIV prevention. The World Health Organization recently recommended Truvada® (Gilead Sciences, Inc.) or tenofovir disoproxil fumarate (TDF) for high-risk individuals ...
J. Fox, M. Brady, H. Alexander, Olubanke Davies, N. Robinson, M. Pace, L. Else, J. Cason, S. Khoo, D. Back, S. Fidler, J. Frater   +11 more
semanticscholar   +1 more source

Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review

Advanced Materials, EarlyView.
Ferrite nanoplatforms are presented as tunable biomedical materials in which synthesis control, cation engineering, defect/morphology regulation, and surface functionalization govern structure–property–bioactivity relationships. These design strategies enable multifunctional applications including MRI contrast, magnetic hyperthermia, targeted drug ...
Pramod D. Mhase, Varsha C. Pujari, Akash V. Fulari, Sunil M. Patange, Sean Li, Danyang Wang, Sagar E. Shirsath   +6 more
wiley   +1 more source

Microglia Exhibit a Unique Intact HIV Reservoir in Human Postmortem Brain Tissue [PDF]

A proviral reservoir persists within the central nervous system (CNS) of people with HIV, but its characteristics remain poorly understood. Research has primarily focused on cerebrospinal fluid (CSF), as acquiring brain tissue is challenging. We examined
Annemarie M. J. Wensing, Ninée V. E. J. Buchholtz, Stephanie B. H. Gumbs, Irene Drosou, Lot D. de Witte, Frederieke A. J. Gigase, Gijsje J. L. J. Snijders, Lavina Gharu, Marieke M. Nühn, Pauline J. Schipper, Jori Symons, Monique Nijhuis   +11 more
core   +1 more source

Interplay between the Lung Microbiome, Pulmonary Immunity and Viral Reservoirs in People Living with HIV under Antiretroviral Therapy [PDF]

, 2022
Pulmonary dysbiosis may predispose people living with HIV (PLWH) to chronic lung disease. Herein, we assessed whether intrapulmonary HIV reservoir size and immune disruption are associated with reduced bacterial lung diversity in PLWH.
Mohammad-Ali Jenabian, Pagliuzza, Amélie, Suzanne Samarani, Olivenstein, Ron, Samarani, Suzanne, Chomont, Nicolas, Jenabian, Mohammad-Ali, Ron Olivenstein, Yulia Alexandrova, Amélie Pagliuzza, Costiniuk, Cecilia T., Nicolas Chomont, Wang, Zihui, Steven W. Kembel, Zihui Wang, Cecilia T. Costiniuk, Kembel, Steven W., Alexandrova, Yulia   +17 more
core   +1 more source