Results 111 to 120 of about 84,140 (293)

Estudio de los cambios virológicos y de inmunidad celular en tejido amigdalar tras tratamiento antiretroviral en pacientes infectados por HIV en estado temprano de la infección [PDF]

, 2007
[spa] Los reservorios del VIH-1 se establecen en fases muy iniciales de la infección. Un estudio reciente documenta la presencia de gran cantidad de ARN vírico en ganglios linfáticos de individuos expuestos dos días después de la aparición de síntomas ...
Navarrete Durán, Pilar
core  

Effect of the Bystander Proliferation of the Latent Reservoir on the Latent Reservoir and on Plasma Viral Load

, 2013
When there is no ongoing viral replication (ɛ = 1) and the minimum activation rate of the latent reservoir is zero (amin = 0). The open circles indicate the decay kinetics of the latent reservoir suggested by Strain et al.
Alan S Perelson (379607), Hwijin Kim (379606)   +1 more
core   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

Biodiversity and distribution of polar freshwater DNA viruses

, 2015
Viruses constitute the most abundant biological entities and a large reservoir of genetic diversity on Earth. Despite the recent surge in their study, our knowledge on their actual biodiversity and distribution remains sparse.
López-Bueno, Alberto, Pearce, David, Pearce, David A., Alcamí, Antonio, Aguirre de Cárcer, Daniel   +4 more
core   +1 more source

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

Microglia Exhibit a Unique Intact HIV Reservoir in Human Postmortem Brain Tissue

A proviral reservoir persists within the central nervous system (CNS) of people with HIV, but its characteristics remain poorly understood. Research has primarily focused on cerebrospinal fluid (CSF), as acquiring brain tissue is challenging. We examined
Annemarie M. J. Wensing, Ninée V. E. J. Buchholtz, Stephanie B. H. Gumbs, Irene Drosou, Lot D. de Witte, Frederieke A. J. Gigase, Gijsje J. L. J. Snijders, Lavina Gharu, Marieke M. Nühn, Pauline J. Schipper, Jori Symons, Monique Nijhuis   +11 more
core   +1 more source

THE RELATIONSHIP BETWEEN RESIDUAL VIREMIA AND CHRONIC INFLAMMATION IN PATIENTS ON LONG-TERM ANTIRETROVIRAL THERAPY [PDF]

, 2013
Since the development of combination antiretroviral therapy, morbidity and mortality due to AIDS-related malignancies has declined significantly. In most patients, daily administration of a multidrug antiretroviral regimen is sufficient to suppress ...
Hilldorfer IV, Benedict B.
core  

Interplay between the Lung Microbiome, Pulmonary Immunity and Viral Reservoirs in People Living with HIV under Antiretroviral Therapy

, 2022
Pulmonary dysbiosis may predispose people living with HIV (PLWH) to chronic lung disease. Herein, we assessed whether intrapulmonary HIV reservoir size and immune disruption are associated with reduced bacterial lung diversity in PLWH.
Mohammad-Ali Jenabian, Pagliuzza, Amélie, Suzanne Samarani, Olivenstein, Ron, Samarani, Suzanne, Chomont, Nicolas, Jenabian, Mohammad-Ali, Ron Olivenstein, Yulia Alexandrova, Amélie Pagliuzza, Costiniuk, Cecilia T., Nicolas Chomont, Wang, Zihui, Steven W. Kembel, Zihui Wang, Cecilia T. Costiniuk, Kembel, Steven W., Alexandrova, Yulia   +17 more
core   +1 more source