Results 111 to 120 of about 956,535 (302)

Appendectomy Mitigates Coxsackievirus B3−Induced Viral Myocarditis

, 2023
Appendix has a distinct abundance of lymphatic cells and serves as a reservoir of microbiota which helps to replenish the large intestine with healthy flora.
Chengrui Niu, Wei Xu, Sidong Xiong
core   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

TZA, a Sensitive Reporter Cell-based Assay to Accurately and Rapidly Quantify Inducible, Replication-competent Latent HIV-1 from Resting CD4+ T Cells

Bio-Protocol, 2019
The latent HIV-1 viral reservoir in resting CD4+ (rCD4+) T cells represents a major barrier to an HIV-1 cure. There is an ongoing effort to identify therapeutic approaches that will eliminate or reduce the size of this reservoir.
Anwesha Sanyal, Vatsala Rangachar, Phalguni Gupta   +2 more
doaj   +1 more source

Boat electrofishing survey of the upper Turitea Reservoir, Palmerston North. [PDF]

, 2009
The upper Turitea Reservoir is a 12-ha reservoir that supplies water to the city of Palmerston North (Figure 1). It was constructed in 1957 and is located in the foothills of the Tararua Ranges at 40.43208°S, 175,67669°E. The 2,300 hectare catchment area
Powrie, Warrick, Hicks, Brendan J., Brijs, Jeroen, Ling, Nicholas, Bell, Dudley G., Blair, Jennifer Marie   +5 more
core  

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Low-level HIV-1 replication and the dynamics of the resting CD4⁺ T cell reservoir for HIV-1 in the setting of HAART

BMC Infectious Diseases, 2008
Background In the setting of highly active antiretroviral therapy (HAART), plasma levels of human immunodeficiency type-1 (HIV-1) rapidly decay to below the limit of detection of standard clinical assays.
Wilke Claus O, Siliciano Robert F, Sedaghat Ahmad R   +2 more
doaj   +1 more source

Neuro-dynamic programming for the efficient management of reservoir networks [PDF]

, 2001
The management of a water reservoir can be improved thanks to the use of stochastic dynamic programming (SDP) to generate management policies which are efficient with respect to the management objectives (flood protection, water supply for irrigation and
Rizzoli, Andrea Emilio, Soncini-Sessa, Rodolfo, Weber, Enrico, SONCINI SESSA, RODOLFO, P. Zenesi, Zenesi, Pietro, A. E. Rizzoli, de Rigo, Daniele   +7 more
core   +1 more source

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

Advanced Science, EarlyView.
Targeted chimeric degraders engage extracellular or membrane proteins and endocytosable cell‐surface receptors, forming ternary complexes that induce receptor‐mediated internalization. Following endocytosis, post‐endocytic sorting—not internalization alone—determines target fate.
Ke Liu, Xiyan Wang, Xiaozhen Liu, Chaoqi He, Da Qian, Xuli Meng, Liquan Zhu   +6 more
wiley   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

HIV-1 reservoir inducibility and immune phenotypes after prolonged analytical treatment interruption: a long-term follow-up studyResearch in context

EBioMedicine
Summary: Background: Despite effective suppression of HIV-1 replication by antiretroviral therapy (ART), persistent viral reservoirs prevent cure and necessitate lifelong treatment.
Cynthia Lungu, Tanvir Hossain, Raquel Crespo, Henrieke A.B. Prins, Kathryn S. Hensley, Casper Rokx, Shringar Rao, Jeroen J.A. van Kampen, David A.M.C. van de Vijver, Thibault Mesplède, Peter D. Katsikis, Rob A. Gruters, Yvonne M. Mueller, Tokameh Mahmoudi   +13 more
doaj   +1 more source