Results 111 to 120 of about 1,595,225 (317)

Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques

Nature Communications, 2021
The existence of HIV reservoir and ongoing replication despite antiretroviral therapy (ART) represents a barrier for cure efforts. Here, using SIV/SHIV-infected rhesus macaque suppressed with ART for one year, the authors characterize multiple lymphoid ...
Anthony M. Cadena, John D. Ventura, Peter Abbink, Erica N. Borducchi, Hubert Tuyishime, Noe B. Mercado, Victoria Walker-Sperling, Mazuba Siamatu, Po-Ting Liu, Abishek Chandrashekar, Joseph P. Nkolola, Katherine McMahan, Nicole Kordana, Venous Hamza, Esther A. Bondzie, Emily Fray, Mithra Kumar, Stephanie Fischinger, Sally A. Shin, Mark G. Lewis, Robert F. Siliciano, Galit Alter, Dan H. Barouch   +22 more
doaj   +1 more source

A Proof‐of‐Concept Assessment of a Novel Wearable Eyelid Muscle Device: A Pre‐Clinical Animal Cadaver Study for Eyelid Closure Restoration

Advanced Robotics Research, EarlyView.
This article introduces a soft wearable eyelid sling device incorporating a hydraulic soft artificial muscle (SAM) for achieving complete closure of an eyelid. The SAM is driven by a cam mechanism that provides a displacement profile closely matched with those of a healthy eyelid.
Patrick Pruscino, Phuoc Thien Phan, James Davies, Bibhu Sharma, Tianruo Guo, Chi Cong Nguyen, Nigel H. Lovell, Thanh Nho Do   +7 more
wiley   +1 more source

The Abundance and Behavior of Viruses in Ancient Seawater and Modern Iron-rich Environments [PDF]

, 2011
The proclivity of silica for ferric hydroxide sorption sites allows for an Archean iron cycle involving iron-silica co-precipitation and deposition of banded iron formations (BIF).
Liu, Hanna Ken-Yuin
core   +1 more source

Deep Thought on the HIV Cured Cases: Where Have We Been and What Lies Ahead?

Biomolecules
Antiretroviral therapy (ART) can effectively suppress the replication of human immunodeficiency virus (HIV), but it cannot completely eradicate the virus. The persistent existence of the HIV reservoir is a major obstacle in the quest for a cure. To date,
Qing Xiao, Sanxiu He, Chaoyu Wang, Yixing Zhou, Chensi Zeng, Jun Liu, Tingting Liu, Tingting Li, Xi Quan, Linyue Wang, Liuyue Zhai, Yi Liu, Jun Li, Xiaomei Zhang, Yao Liu   +14 more
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Peripheral immune responses to filoviruses in a reservoir versus spillover hosts reveal transcriptional correlates of disease

Frontiers in Immunology
Several filoviruses, including Marburg virus (MARV), cause severe disease in humans and nonhuman primates (NHPs). However, the Egyptian rousette bat (ERB, Rousettus aegyptiacus), the only known MARV reservoir, shows no overt illness upon natural or ...
Jonathan C. Guito, Catherine E. Arnold, Catherine E. Arnold, Amy J. Schuh, Brian R. Amman, Tara K. Sealy, Jessica R. Spengler, Jessica R. Harmon, Joann D. Coleman-McCray, Mariano Sanchez-Lockhart, Gustavo F. Palacios, Jonathan S. Towner, Joseph B. Prescott, Joseph B. Prescott   +13 more
doaj   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART. [PDF]

, 2019
The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years.
von Siebenthal, Chantal, Bachmann, Nadine, Battegay, Manuel, Yerly, Sabine, Perreau, M., Fellay, Jaques, Vongrad, Valentina, Battegay, M., Böni, J., Swiss HIV Cohort Study, Günthard, Huldrych F., Neumann, Kathrin, Metzner, Karin J, Bogojeska, Jasmina, Beerenwinkel, Niko; id_orcid, Metzner, K.J., Klimkait, Thomas, Roth, V., Thorball, C.W., Kouyos, R.D., Beerenwinkel, N., Yerly, S., Yerly Ferrillo, Sabine, Wieser, M., Bernasconi, E., Vongrad, V., von Siebenthal, C., Günthard, Huldrych F, Kouyos, Roger D., Hoffmann, Matthias, Parbhoo, Sonali, Beerenwinkel, Niko, Parbhoo, S., Cavassini, M., Böni, Jürg, Bogojeska, J., Fellay, J., Rauch, A., Kok, Y.L., Bernasconi, Enos, Kouyos, Roger D, and the Swiss HIV Cohort Study, Roth, Volker, Kok, Yik Lim, Borghesi, Alessandro, Rauch, Andri, Neumann, K., Borghesi, A., Hoffmann, M., Thorball, Christian W, Günthard, H.F., Bachmann, N., Klimkait, T., Turk, T., Thorball, Christian W., Metzner, Karin J., Turk, Teja, Perreau, Matthieu, Wieser, Mario, Cavassini, Matthias   +59 more
core   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Neutralizing the threat: harnessing broadly neutralizing antibodies against HIV-1 for treatment and prevention

Microbial Cell
Broadly neutralizing antibodies (bnAbs) targeting the human immunodeficiency virus-1 (HIV-1) have played a crucial role in elucidating and characterizing neutralization-sensitive sites on the HIV-1 envelope spike and in informing vaccine development ...
Juan C Becerra, Lauren Hitchcock, Khoa Vu, Johannes S Gach   +3 more
doaj   +1 more source