Results 121 to 130 of about 1,595,225 (317)

HIV-1 variants are archived throughout infection and persist in the reservoir.

PLoS Pathogens, 2020
The HIV-1 reservoir consists of latently infected cells that persist despite antiretroviral therapy (ART). Elucidating the proviral genetic composition of the reservoir, particularly in the context of pre-therapy viral diversity, is therefore important ...
Kelsie Brooks, Bradley R Jones, Dario A Dilernia, Daniel J Wilkins, Daniel T Claiborne, Samantha McInally, Jill Gilmour, William Kilembe, Jeffrey B Joy, Susan A Allen, Zabrina L Brumme, Eric Hunter   +11 more
doaj   +1 more source

Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection

PLoS Pathogens, 2015
Two of the crucial aspects of human immunodeficiency virus (HIV) infection are (i) viral persistence in reservoirs (precluding viral eradication) and (ii) chronic inflammation (directly associated with all-cause morbidities in antiretroviral therapy (ART)
A. Damouche, T. Lazure, V. Avettand-Fenoël, N. Huot, N. Dejucq-Rainsford, A. Satié, A. Mélard, L. David, C. Gommet, J. Ghosn, N. Noel, G. Pourcher, V. Martinez, S. Benoist, V. Béréziat, Antonio Cosma, B. Favier, B. Vaslin, C. Rouzioux, J. Capeau, M. Müller-Trutwin, N. Dereuddre-Bosquet, R. Le Grand, O. Lambotte, C. Bourgeois   +24 more
semanticscholar   +1 more source

FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model

Advanced Science, EarlyView.
FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble, Wiktor Zywicki, Enrico Lucarelli, Ania Naila Guerrieri, Francesca Taraballi, Gianluca Cidonio, Claudia Di Bella, Carmine Onofrillo, Andrea J. O'Connor, Serena Duchi   +9 more
wiley   +1 more source

A stochastic model of latently infected cell reactivation and viral blip generation in treated HIV patients.

PLoS Computational Biology, 2011
Motivated by viral persistence in HIV+ patients on long-term anti-retroviral treatment (ART), we present a stochastic model of HIV viral dynamics in the blood stream.
Jessica M Conway, Daniel Coombs
doaj   +1 more source

Solar‐Driven Bifunctional Adsorption‐Storage Films for Ultra‐Fast Dehumidification and Freshwater Supply in Low‐carbon Buildings

Advanced Science, EarlyView.
Bifunctional adsorption‐storage films enable autonomous indoor humidity regulation and freshwater harvesting, rapidly decreasing relative humidity from 90.7% to 21.6% within one hour while producing 1.1 kg·m−2·day−1 of water, offering a passive route towards energy‐efficient humidity control and sustainable indoor environments. ABSTRACT Indoor humidity
Yuechao Chao, Junwei Liu, Zhihua Zhou, Yahui Du, Hailu Wei, Haibin Yang, Xueqing Yang, Cheng Wang, Zhenzhong Zeng, Hongzhi Cui, Jinyue Yan   +10 more
wiley   +1 more source

Editorial: Immune barrier, viral sanctuaries, and sexual transmission in the male reproductive system

Frontiers in Immunology, 2023
Jing Zhang, Wei Lu, C. Yan Cheng, Daishu Han   +3 more
doaj   +1 more source

Immune checkpoint inhibitors in HIV infection: current evidence on viral reservoir regulation and immune restoration

Frontiers in Immunology
Immune checkpoint inhibitors (ICIs), particularly those targeting the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) axis, have emerged as potential tools beyond cancer immunotherapy in people with HIV (PWH).
Yixuan Wang, Xin Huang, Liyuan Zheng, Ling Luo, Taisheng Li, Wei Cao   +5 more
doaj   +1 more source

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

Advanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang   +8 more
wiley   +1 more source

Establishment of the SIV Reservoir and Mechanisms of Viral Rebound in Rhesus Monkeys [PDF]

, 2020
ART leads to durable suppression of HIV-1 replication in the majority of individuals, but the persistent viral reservoir in resting memory CD4+ T cells is the key barrier to HIV-1 cure.
Liu, Po-Ting
core  

Episomal Viral cDNAs Identify a Reservoir That Fuels Viral Rebound after Treatment Interruption and That Contributes to Treatment Failure [PDF]

, 2011
Viral reservoirs that persist in HIV-1 infected individuals on antiretroviral therapy (ART) are the major obstacle to viral eradication. The identification and definition of viral reservoirs in patients on ART is needed in order to understand viral ...
Daniel R. Kuritzkes, Stevenson, Mario, Roy Gulick, Kuritzkes, Daniel, Gulick, Roy, Babic, Dunja Z, Thomas Greenough, Babic, Dunja Z., Dunja Z Babic, Mark Sharkey, Kuritzkes, Daniel R, Greenough, Thomas, Sharkey, Mark, Cullen, Bryan R., Mario Stevenson, Daniel R Kuritzkes, Dunja Z. Babic   +16 more
core   +1 more source