Results 121 to 130 of about 84,140 (293)

Different polarization and functionality of CD4+ T helper subsets in people with post-COVID condition

Frontiers in Immunology
IntroductionAfter mild COVID-19 that does not require hospitalization, some individuals develop persistent symptoms that may worsen over time, producing a multisystemic condition termed Post-COVID condition (PCC).
Clara Sánchez-Menéndez, Clara Sánchez-Menéndez, Clara Sánchez-Menéndez, Olivia de la Calle-Jiménez, Olivia de la Calle-Jiménez, Olivia de la Calle-Jiménez, Elena Mateos, Elena Mateos, Lorena Vigón, Daniel Fuertes, María Aranzazu Murciano Antón, María Aranzazu Murciano Antón, Esther San José, Valentín García-Gutiérrez, Miguel Cervero, Montserrat Torres, Montserrat Torres, Mayte Coiras, Mayte Coiras   +18 more
doaj   +1 more source

A Novel Single-Cell FISH-Flow Assay Identifies Effector Memory CD4⁺ T cells as a Major Niche for HIV-1 Transcription in HIV-Infected Patients

mBio, 2017
Cells that actively transcribe HIV-1 have been defined as the “active viral reservoir” in HIV-infected individuals. However, important technical limitations have precluded the characterization of this specific viral reservoir during both treated and ...
Judith Grau-Expósito, Carla Serra-Peinado, Lucia Miguel, Jordi Navarro, Adrià Curran, Joaquin Burgos, Imma Ocaña, Esteban Ribera, Ariadna Torrella, Bibiana Planas, Rosa Badía, Josep Castellví, Vicenç Falcó, Manuel Crespo, Maria J. Buzon   +14 more
doaj   +1 more source

FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model

Advanced Science, EarlyView.
FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble, Wiktor Zywicki, Enrico Lucarelli, Ania Naila Guerrieri, Francesca Taraballi, Gianluca Cidonio, Claudia Di Bella, Carmine Onofrillo, Andrea J. O'Connor, Serena Duchi   +9 more
wiley   +1 more source

EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment

PLOS Pathogens, 2018
Suppression of HIV replication by antiretroviral therapy (ART) or host immunity can prevent AIDS but not other HIV-associated conditions including neurocognitive impairment (HIV-NCI). Pathogenesis in HIV-suppressed individuals has been attributed to reservoirs of latent-inducible virus in resting CD4+ T cells. Macrophages are persistently infected with
Chao-Jiang Gu, Alejandra Borjabad, Eran Hadas, Jennifer Kelschenbach, Boe-Hyun Kim, Wei Chao, Ottavio Arancio, Jin Suh, Bruce Polsky, JoEllyn McMillan, Benson Edagwa, Howard E. Gendelman, Mary Jane Potash, David J. Volsky   +13 more
openaire   +4 more sources

The X awakens: multifactorial ramifications of sex-specific differences in HIV-1 infection

Journal of Virus Eradication, 2016
Sex-specific differences have been described for a variety of infectious and autoimmune diseases. In HIV-1 infection women present with significantly lower viral loads during early infection, but during chronic infection women progress faster to AIDS for
Sven Hagen, Marcus Altfeld
doaj   +1 more source

Solar‐Driven Bifunctional Adsorption‐Storage Films for Ultra‐Fast Dehumidification and Freshwater Supply in Low‐carbon Buildings

Advanced Science, EarlyView.
Bifunctional adsorption‐storage films enable autonomous indoor humidity regulation and freshwater harvesting, rapidly decreasing relative humidity from 90.7% to 21.6% within one hour while producing 1.1 kg·m−2·day−1 of water, offering a passive route towards energy‐efficient humidity control and sustainable indoor environments. ABSTRACT Indoor humidity
Yuechao Chao, Junwei Liu, Zhihua Zhou, Yahui Du, Hailu Wei, Haibin Yang, Xueqing Yang, Cheng Wang, Zhenzhong Zeng, Hongzhi Cui, Jinyue Yan   +10 more
wiley   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

AIDS update 1999: Viral reservoirs and immune-based therapies

Cleveland Clinic Journal of Medicine, 1999
The advent of highly active antiretroviral therapy (HAART) has brought about a dramatic decline in opportunistic infections, hospitalizations, and mortality in AIDS patients. However, the recent discovery that HIV can lay dormant in quiescent T cells and other tissues even in the face of HAART therapy has dampened optimism for a cure for AIDS, though ...
W. S. WILKE, C. M. ISADA, L. H. CALABRESE   +2 more
openaire   +2 more sources

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Barcoded HIV-1 reveals viral persistence driven by clonal proliferation and distinct epigenetic patterns

Nature Communications
The HIV reservoir consists of infected cells in which the HIV-1 genome persists as provirus despite effective antiretroviral therapy (ART). Studies exploring HIV cure therapies often measure intact proviral DNA levels, time to rebound after ART ...
Tian-hao Zhang, Yuan Shi, Natalia L. Komarova, Dominik Wodarz, Matthew Kostelny, Alexander Gonzales, Izra Abbaali, Hongying Chen, Gabrielle Bresson-Tan, Melanie Dimapasoc, William Harvey, Christopher Oh, Camille Carmona, Christopher Seet, Yushen Du, Ren Sun, Jerome A. Zack, Jocelyn T. Kim   +17 more
doaj   +1 more source