Results 141 to 150 of about 1,595,225 (317)

Lessons from the host defences of bats, a unique viral reservoir

Nature, 2021
Aaron T. Irving, Matae Ahn, G. Goh, D. Anderson, Lin‐Fa Wang   +4 more
semanticscholar   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Estudio de los cambios virológicos y de inmunidad celular en tejido amigdalar tras tratamiento antiretroviral en pacientes infectados por HIV en estado temprano de la infección [PDF]

, 2007
[spa] Los reservorios del VIH-1 se establecen en fases muy iniciales de la infección. Un estudio reciente documenta la presencia de gran cantidad de ARN vírico en ganglios linfáticos de individuos expuestos dos días después de la aparición de síntomas ...
Navarrete Durán, Pilar
core  

In-host modeling of Tfh–Tfr–fCD8+ T cell dynamics on HIV reservoir persistence

Frontiers in Applied Mathematics and Statistics
HIV persistence within germinal centers is driven by complex interactions among T follicular helper (Tfh), T follicular regulatory (Tfr), and follicular CD8+ (fCD8+) T cells. Yet, the mechanisms sustaining the viral reservoir remain poorly understood. We
Faraimunashe Chirove, Koffi Messan Agbavon   +1 more
doaj   +1 more source

Failure of daily tenofovir to prevent HIV transmission or the establishment of a significant viral reservoir despite continued antiretroviral therapy

Journal of the International AIDS Society, 2014
Truvada is licenced for HIV‐1 prevention in the USA and is available in the private sector. Tenofovir performed as well as Truvada in the PARTNERS PrEP study and is used as HIV pre‐exposure prophylaxis (PreP) in some settings.
Olubanke Davies, H. Alexander, N. Robinson, M. Pace, M. Brady, J. Frater, J. Fox   +6 more
semanticscholar   +1 more source

A Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions

Advanced Science, EarlyView.
An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu, Guorui Xing, He Dong, Qiulong Yan, Shenghui Li, Xiaohui Zou, Bin Cao   +15 more
wiley   +1 more source

Seoul orthohantavirus evades innate immune activation by reservoir endothelial cells.

PLoS Pathogens
Pathogenic hantaviruses are maintained world-wide within wild, asymptomatic rodent reservoir hosts, with increasingly frequent human spillover infections resulting in severe hemorrhagic fever or cardio-pulmonary disease.
Stefan D Klimaj, Autumn LaPointe, Kimberly Martinez, Eduardo Hernandez Acosta, Alison M Kell   +4 more
doaj   +1 more source

TZA, a Sensitive Reporter Cell-based Assay to Accurately and Rapidly Quantify Inducible, Replication-competent Latent HIV-1 from Resting CD4+ T Cells

Bio-Protocol, 2019
The latent HIV-1 viral reservoir in resting CD4+ (rCD4+) T cells represents a major barrier to an HIV-1 cure. There is an ongoing effort to identify therapeutic approaches that will eliminate or reduce the size of this reservoir.
Anwesha Sanyal, Vatsala Rangachar, Phalguni Gupta   +2 more
doaj   +1 more source

Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound

Nature Medicine, 2018
Prophylactic vaccination of rhesus macaques with rhesus cytomegalovirus (RhCMV) vectors expressing simian immunodeficiency virus (SIV) antigens (RhCMV/SIV) elicits immune responses that stringently control highly pathogenic SIV infection, with subsequent
A. Okoye, S. Hansen, M. Vaidya, Y. Fukazawa, Haesun Park, D. Duell, R. Lum, Colette M. Hughes, A. Ventura, Emily Ainslie, Julia C. Ford, David W. Morrow, Roxanne M. Gilbride, Alfred W Legasse, J. Hesselgesser, R. Geleziunas, Yuan Li, K. Oswald, R. Shoemaker, R. Fast, W. Bosche, B. Borate, P. Edlefsen, M. Axthelm, L. Picker, J. Lifson   +25 more
semanticscholar   +1 more source

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, EarlyView.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source