Results 151 to 160 of about 1,595,225 (317)

Low-level HIV-1 replication and the dynamics of the resting CD4⁺ T cell reservoir for HIV-1 in the setting of HAART

BMC Infectious Diseases, 2008
Background In the setting of highly active antiretroviral therapy (HAART), plasma levels of human immunodeficiency type-1 (HIV-1) rapidly decay to below the limit of detection of standard clinical assays.
Wilke Claus O, Siliciano Robert F, Sedaghat Ahmad R   +2 more
doaj   +1 more source

Adaptive Responses of Tropical Crops: A Multi‐Scale Omics Integrated Perspective

Advanced Science, EarlyView.
Tropical crops integrate genomic, morphological, physiological, and ecological adaptations to thrive under extreme and variable environments. This review highlights how natural selection, domestication, and breeding shape stress resilience, resource‐use strategies, and productivity in sugarcane, banana, cassava, rubber and oil palm, offering new routes
Peilin Wang, Chenhui Li, Dongjiao Wang, Qibin Wu, Zhen Zeng, Huiming Guo, Han Cheng, Songbi Chen, Hongxing Cao, Hongmei Cheng, Jianghui Xie, Youxiong Que   +11 more
wiley   +1 more source

Distinct biomarker signatures in HIV acute infection associate with viral dynamics and reservoir size.

JCI Insight, 2018
Estimating the size of the viral reservoir is critical for HIV cure strategies. Biomarkers in peripheral circulation may give insights into the establishment of the viral reservoir in compartments not easily accessible.
J. Teigler, Louise Leyre, N. Chomont, B. Slike, Ningbo Jian, M. Eller, N. Phanuphak, E. Kroon, S. Pinyakorn, L. Eller, M. Robb, J. Ananworanich, N. Michael, H. Streeck, S. Krebs   +14 more
semanticscholar   +1 more source

From Marginal to Central: Marginal Zone‐like B Cells as Critical Targets in Cladribine‐Treated Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Multiple sclerosis (MS) is a chronic autoimmune disease where B cells play a central pathogenic role. Cladribine, an oral therapy, provides durable benefits by reshaping lymphocyte populations, yet its specific long‐term impact on distinct B‐cell subsets is not fully understood.
Marta Pirronello, Mario Picozza, Gisella Guerrera, Silvia Corbisiero, Andrea Misiti, Roberta C. Placido, Alice Verdiani, Lorenzo de Marco, Manolo Sambucci, Elena Olivieri, Daniela F. Angelini, Esmeralda Quartuccio, Luca Prosperini, Carla Tortorella, Maria C. Buscarinu, Valeria Zancan, Francesca de Masi, Marco Salvetti, Claudio Gasperini, Giovanna Borsellino, Luca Battistini   +20 more
wiley   +1 more source

THE RELATIONSHIP BETWEEN RESIDUAL VIREMIA AND CHRONIC INFLAMMATION IN PATIENTS ON LONG-TERM ANTIRETROVIRAL THERAPY [PDF]

, 2013
Since the development of combination antiretroviral therapy, morbidity and mortality due to AIDS-related malignancies has declined significantly. In most patients, daily administration of a multidrug antiretroviral regimen is sufficient to suppress ...
Hilldorfer IV, Benedict B.
core  

PEG Alternatives in Liposomal Nanocarriers: Physicochemical Characteristics and Sustainable Process Strategies

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The global trend toward sustainable and intensified bioprocesses is driving innovation in the design and scalable synthesis of liposomal nanocarriers, a cornerstone of modern drug delivery. For decades, these nanosystems have relied exclusively on polyethylene glycol (PEG) for their sustained circulation in vivo, but they are currently ...
Chandra Has
wiley   +1 more source

HIV-1 reservoir inducibility and immune phenotypes after prolonged analytical treatment interruption: a long-term follow-up studyResearch in context

EBioMedicine
Summary: Background: Despite effective suppression of HIV-1 replication by antiretroviral therapy (ART), persistent viral reservoirs prevent cure and necessitate lifelong treatment.
Cynthia Lungu, Tanvir Hossain, Raquel Crespo, Henrieke A.B. Prins, Kathryn S. Hensley, Casper Rokx, Shringar Rao, Jeroen J.A. van Kampen, David A.M.C. van de Vijver, Thibault Mesplède, Peter D. Katsikis, Rob A. Gruters, Yvonne M. Mueller, Tokameh Mahmoudi   +13 more
doaj   +1 more source

Establishment of Interspecies Somatic Cell Nuclear Transfer and Transgene‐Free Inducible Pluripotent Stem Cells for Versatile Conservation of the Germplasm Resource of Wild Boar

Animal Research and One Health, EarlyView.
Conserving genetic material and even increasing genetic diversity is critical. To conduct the conservation of wild boar germplasm resources, we have successfully obtained healthy cloned wild boars for the first time using interspecies somatic cell nuclear transfer and established transgene‐free iPSCs that can be used to conduct iterative rounds of gene
Chen Gao, Xinyi Zhou, Shigang Gu, Jianbo Li, Jing Wang, Yurong Zhang, Wenxuan Zhao, Xinhua Wei, Liting Lu, Quanmin Zhao, Yongye Huang, Dawei Yu   +11 more
wiley   +1 more source

Anti-HIV therapy: pipeline approaches and future directions [PDF]

, 2011
Human immunodeficiency virus (HIV), with about 30 million deaths and double infections (in developing countries), is an open challenge today for global scientists.
Lavkush Dwivedi, Mansi Shrivastava
core   +2 more sources

Stimulating the RIG-I pathway to kill cells in the latent HIV reservoir following viral reactivation

Nature Medicine, 2016
The persistence of latent HIV proviruses in long-lived CD4+ T cells despite antiretroviral therapy (ART) is a major obstacle to viral eradication. Because current candidate latency-reversing agents (LRAs) induce HIV transcription, but fail to clear these
Peilin Li, Philipp Kaiser, H. Lampiris, P. Kim, S. Yukl, D. Havlir, W. Greene, J. Wong   +7 more
semanticscholar   +1 more source