Results 51 to 60 of about 956,535 (302)

Unveiling altered CD8 T-cell metabolism and homeostatic proliferation behind a low CD4/CD8 ratio in ART-suppressed HIV individuals with normal CD4 recovery

Frontiers in Immunology
BackgroundPeople living with chronic HIV (PLWH) show immune dysfunction, despite viral suppression and normal CD4 recovery, particularly those with low CD4/CD8 ratios.
Vanesa Garrido-Rodríguez, Ángel Bulnes-Ramos, Israel Olivas-Martínez, María del Mar Pozo-Balado, Francisco Tejerina-Picado, Francisco Tejerina-Picado, Félix Gutiérrez, Félix Gutiérrez, Cristina Marco-Sánchez, Juan Manuel Tiraboschi, Antonia Castillo-Navarro, Enrique Bernal, Maria C. Garcia-Guerrero, Maria C. Puertas, Maria C. Puertas, Joaquim Peraire, Joaquim Peraire, Joaquim Peraire, Joaquim Peraire, Anna Rull, Anna Rull, Anna Rull, Anna Rull, Javier Martinez-Picado, Javier Martinez-Picado, Javier Martinez-Picado, Javier Martinez-Picado, Yolanda María Pacheco, Yolanda María Pacheco   +28 more
doaj   +1 more source

Viral genomic features predict orthopoxvirus reservoir hosts

Communications Biology, 2023
Abstract Orthopoxviruses (OPVs), including the causative agents of smallpox and mpox have led to devastating outbreaks in human populations worldwide. However, the discontinuation of smallpox vaccination, which also provides cross-protection against related OPVs, has diminished global immunity to OPVs more broadly.
Katie K. Tseng, Heather Koehler, Daniel J. Becker, Rory Gibb, Colin J. Carlson, Maria del Pilar Fernandez, Stephanie N. Seifert   +6 more
openaire   +4 more sources

Forging a Functional Cure for HIV: Transcription Regulators and Inhibitors

Viruses, 2022
Current antiretroviral therapy (ART) increases the survival of HIV-infected individuals, yet it is not curative. The major barrier to finding a definitive cure for HIV is our inability to identify and eliminate long-lived cells containing the dormant ...
Sonia Mediouni, Shuang Lyu, Susan M. Schader, Susana T. Valente   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Detectable HIV-1 in semen in individuals with very low blood viral loads

Virology Journal, 2020
Background Several reports indicate that a portion (5–10%) of men living with HIV-1 intermittently shed HIV-1 RNA into seminal plasma while on long term effective antiretroviral therapy (ART).
Samuel Mundia Kariuki, Philippe Selhorst, Jennifer Norman, Karen Cohen, Kevin Rebe, Carolyn Williamson, Jeffrey R. Dorfman   +6 more
doaj   +1 more source

Reservoir computing with output feedback [PDF]

, 2011
Reinhart RF. Reservoir computing with output feedback. Bielefeld: Bielefeld University; 2011.A dynamical system approach to forward and inverse modeling is proposed. Forward and inverse models are trained in associative recurrent neural networks that are
Reinhart, René Felix, Reinhart, Felix
core   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

The pathogenesis of zoonotic viral infections: Lessons learned by studying reservoir hosts

Frontiers in Microbiology, 2023
Zoonotic viral infections that cause severe disease or even death in some people may be asymptomatic or mild in reservoir hosts. Comparison of the pathogenesis of these two host categories may potentially explain the difference in disease.
Lineke Begeman, Debby van Riel, Marion P. G. Koopmans, Marion P. G. Koopmans, Thijs Kuiken   +4 more
doaj   +1 more source

Qualitative plasma viral load determination as a tool for screening of viral reservoir size in PWH

AIDS, 2022
Objective(s): Suppression of viral replication in patients on antiretroviral therapy (ART) is determined by plasma viral load (pVL) measurement. Whenever pVL reaches values below the limit of quantification, the qualitative parameter ’target detected’ or ’target not detected’ is available but often not reported to the clinician.
Laeremans, Thessa, D'haese, Sigrid, Aernout, Jonathan, Barbé, Kurt, Pannus, Pieter, Rutsaert, Sofie, Vancutsem, Ellen, Vanham, Guido, Necsoi, Coca, Spiegelaere, Ward De, Couttenye, Marie, Herssens, Natacha, Scheerder, Marie-Angélique De, Wit, Stéphane De, Vandekerckhove, Linos, Eric, Florence, Aerts, Joeri L, Allard, Sabine D   +17 more
openaire   +4 more sources