Results 51 to 60 of about 84,140 (293)

Viral genomic features predict orthopoxvirus reservoir hosts

Communications Biology, 2023
Abstract Orthopoxviruses (OPVs), including the causative agents of smallpox and mpox have led to devastating outbreaks in human populations worldwide. However, the discontinuation of smallpox vaccination, which also provides cross-protection against related OPVs, has diminished global immunity to OPVs more broadly.
Katie K. Tseng, Heather Koehler, Daniel J. Becker, Rory Gibb, Colin J. Carlson, Maria del Pilar Fernandez, Stephanie N. Seifert   +6 more
openaire   +4 more sources

Impacts of HIV Cure Interventions on Viral Reservoirs in Tissues [PDF]

Frontiers in Microbiology, 2019
HIV reservoirs persist in infected individuals despite combination antiretroviral therapy and can be identified in secondary lymphoid tissues, in intestinal tissues, in the central nervous system as well as in blood. Clinical trials have begun to explore effects of small molecule interventions to perturb the latent viral infection, but only limited ...
Paul W. Denton, Ole S. Søgaard, Ole S. Søgaard, Martin Tolstrup, Martin Tolstrup   +4 more
openaire   +3 more sources

Detectable HIV-1 in semen in individuals with very low blood viral loads

Virology Journal, 2020
Background Several reports indicate that a portion (5–10%) of men living with HIV-1 intermittently shed HIV-1 RNA into seminal plasma while on long term effective antiretroviral therapy (ART).
Samuel Mundia Kariuki, Philippe Selhorst, Jennifer Norman, Karen Cohen, Kevin Rebe, Carolyn Williamson, Jeffrey R. Dorfman   +6 more
doaj   +1 more source

The Reservoir of Persistent Human Papillomavirus Infection; Strategies for Elimination Using Anti-Viral Therapies.

, 2022
Human Papillomaviruses have co-evolved with their human host, with each of the over 200 known HPV types infecting distinct epithelial niches to cause diverse disease pathologies.
Maki Okamura, Heather M. Griffin, Aslam Shiraz, Nagayasu Egawa, Ke Zheng, John Doorbar, Mayako Katakuse   +6 more
core   +1 more source

CCR5 gene editing and HIV immunotherapy: current understandings, challenges, and future directions

Frontiers in Immunology
Human immunodeficiency virus (HIV) infection remains a major global public health challenge. Although highly active antiretroviral therapy (HAART or ART) can effectively control viral replication, it fails to eradicate latent viral reservoirs and poses ...
Jia-Wen Wang, Jia-Hui Liu, Jian-Jun Xun
doaj   +1 more source

The immune gene repertoire of an important viral reservoir, the Australian black flying fox [PDF]

, 2012
BACKGROUND: Bats are the natural reservoir host for a range of emerging and re-emerging viruses, including SARS-like coronaviruses, Ebola viruses, henipaviruses and Rabies viruses.
Field, HE, Papenfuss, Anthony T., Baker, ML, Chris Cowled, Vijaya Janardhana, Lin-Fa Wang, Feng, Zhi-Ping, Wang, Lin-Fa, Tachedjian, Mary, Gary Crameri, Field, Hume E., Cowled, C, Mary Tachedjian, Cowled, Chris, Feng, ZP, Justin Ng, Wang, LF, Ng, J, Tachedjian, M, Crameri, G, Baker, Michelle L., Ng, Justin, Zhi-Ping Feng, Michelle L Baker, Papenfuss, AT, Crameri, Gary, Anthony T Papenfuss, Janardhana, V, Janardhana, Vijaya, Hume E Field   +29 more
core   +1 more source

Human Immunodeficiency Virus Playing Hide-and-Seek: Understanding the TFH Cell Reservoir and Proposing Strategies to Overcome the Follicle Sanctuary

Frontiers in Immunology, 2017
Human immunodeficiency virus (HIV) infects millions of people worldwide, and new cases continue to emerge. Once infected, the virus cannot be cleared by the immune system and causes acquired immunodeficiency syndrome.
Yew Ann Leong, Anurag Atnerkar, Di Yu, Di Yu   +3 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Unveiling altered CD8 T-cell metabolism and homeostatic proliferation behind a low CD4/CD8 ratio in ART-suppressed HIV individuals with normal CD4 recovery

Frontiers in Immunology
BackgroundPeople living with chronic HIV (PLWH) show immune dysfunction, despite viral suppression and normal CD4 recovery, particularly those with low CD4/CD8 ratios.
Vanesa Garrido-Rodríguez, Ángel Bulnes-Ramos, Israel Olivas-Martínez, María del Mar Pozo-Balado, Francisco Tejerina-Picado, Francisco Tejerina-Picado, Félix Gutiérrez, Félix Gutiérrez, Cristina Marco-Sánchez, Juan Manuel Tiraboschi, Antonia Castillo-Navarro, Enrique Bernal, Maria C. Garcia-Guerrero, Maria C. Puertas, Maria C. Puertas, Joaquim Peraire, Joaquim Peraire, Joaquim Peraire, Joaquim Peraire, Anna Rull, Anna Rull, Anna Rull, Anna Rull, Javier Martinez-Picado, Javier Martinez-Picado, Javier Martinez-Picado, Javier Martinez-Picado, Yolanda María Pacheco, Yolanda María Pacheco   +28 more
doaj   +1 more source

Latent HIV dynamics and implications for sustained viral suppression in the absence of antiretroviral therapy

Journal of Virus Eradication, 2018
Objectives: The interaction between HIV and the immune system gives rise to a complex dynamical system. We therefore investigate whether delayed viral rebound after antiretroviral therapy (ART) interruption (ATI) may be due to an individual's viral ...
John M. Murray
doaj   +1 more source