Results 31 to 40 of about 956,535 (302)
Plasma HIV viral rebound following protocol-indicated cessation of ART commenced in primary and chronic HIV infection. [PDF]
, 2012 OBJECTIVES: The magnitude of HIV viral rebound following ART cessation has consequences for clinical outcome and onward transmission. We compared plasma viral load (pVL) rebound after stopping ART initiated in primary (PHI) and chronic HIV infection (CHI)
López-Diéguez, María +83 more
core +1 more source
Lnc(ing)RNAs to the “shock and kill” strategy for HIV-1 cure
Molecular Therapy: Nucleic Acids, 2021 The advent of antiretroviral therapy almost 25 years ago has transformed HIV-1 infection into a manageable chronic condition, albeit still incurable. The inability of the treatment regimen to eliminate latently infected cells that harbor the virus in an ...
Saikat Boliar, David G. Russell
doaj +1 more source
Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity [PDF]
, 2011 Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman +53 more
core +3 more sources
HTLV-1 as a Model for Virus and Host Coordinated Immunoediting
Frontiers in Immunology, 2019 Immunoediting is a process that occurs in cancer, whereby the immune system acts to initially repress, and subsequently promote the outgrowth of tumor cells through the stages of elimination, equilibrium, and escape.
Talia M. Mota +2 more
doaj +1 more source
Viral Abundance and Diversity of Production Fluids in Oil Reservoirs [PDF]
Microorganisms, 2020 Viruses are widely distributed in various ecosystems and have important impacts on microbial evolution, community structure and function and nutrient cycling in the environment. Viral abundance, diversity and distribution are important for a better understanding of ecosystem functioning and have often been investigated in marine, soil, and other ...
Liangcan Zheng +9 more
openaire +3 more sources
Domestic Animals as Potential Reservoirs of Zoonotic Viral Diseases
Annual Review of Animal Biosciences, 2023 Zoonoses are diseases and infections naturally transmitted between humans and vertebrate animals. Over the years, zoonoses have become increasingly significant threats to global health. They form the dominant group of diseases among the emerging infectious diseases (EID) and currently account for 73% of EID.
Oyewale, Tomori, Daniel O, Oluwayelu
openaire +2 more sources
Journal of Virus Eradication, 2021 HIV-1 is able to persist in the face of potent antiretroviral therapy (ART). A number of strategies are being explored to allow ART-free viral remission or viral eradication.
M. Vignoles +8 more
doaj +1 more source
Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy. [PDF]
PLoS Computational Biology, 2009 Although potent combination therapy is usually able to suppress plasma viral loads in HIV-1 patients to below the detection limit of conventional clinical assays, a low level of viremia frequently can be detected in plasma by more sensitive assays ...
Libin Rong, Alan S Perelson
doaj +1 more source
Redefining the Viral Reservoirs that Prevent HIV-1 Eradication [PDF]
Immunity, 2012 This Perspective proposes definitions for key terms in the field of HIV-1 latency and eradication. In the context of eradication, a reservoir is a cell type that allows persistence of replication-competent HIV-1 on a timescale of years in patients on optimal antiretroviral therapy. Reservoirs act as a barrier to eradication in the patient population in
Eisele, Evelyn, Siliciano, Robert F.
openaire +2 more sources
Cellular Reservoirs of HIV-1 and their Role in Viral Persistence [PDF]
Current HIV Research, 2008 A major obstacle in human immunodeficiency virus type 1 (HIV-1) eradication is the ability of the virus to remain latent in a subpopulation of the cells it infects. Latently infected cells can escape the viral immune response and persist for long periods of time, despite the presence of successful highly active antiretroviral therapy (HAART). Given the
Aikaterini, Alexaki +2 more
openaire +2 more sources