Predicting Post-treatment HIV Remission: Does Size of the Viral Reservoir Matter? [PDF]
Frontiers in Microbiology, 2021 Combination antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) replication and improves immune function. However, due to the persistence of long-lived HIV reservoirs, therapy interruption almost inevitably leads to a fast viral ...
Alexander O. Pasternak +2 more
doaj +2 more sources
Neuroinvasion and Viral Reservoir in COVID-19. [PDF]
Cureus, 2020 The new coronavirus disease 2019 (COVID-19) has a remarkably high transmissibility potential and sometimes invades the central nervous system (CNS). The study of the involvement of the nervous system in the pathogenesis of the disease is especially interesting.
Altable Pérez M, De la Serna JM.
europepmc +4 more sources
Immune checkpoint inhibitors in HIV infection: current evidence on viral reservoir regulation and immune restoration [PDF]
Frontiers in ImmunologyImmune checkpoint inhibitors (ICIs), particularly those targeting the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) axis, have emerged as potential tools beyond cancer immunotherapy in people with HIV (PWH).
Yixuan Wang +5 more
doaj +2 more sources
Modeling HIV persistence, the latent reservoir, and viral blips [PDF]
Journal of Theoretical Biology, 2009 HIV-1 eradication from infected individuals has not been achieved with the prolonged use of highly active antiretroviral therapy (HAART). The cellular reservoir for HIV-1 in resting memory CD4(+) T cells remains a major obstacle to viral elimination. The reservoir does not decay significantly over long periods of time but is able to release replication-
Libin Rong, Alan S. Perelson
exaly +3 more sources
Adipose Tissue in SARS-CoV-2 Viral Tropism, Viral Replication, and the Concept of a Viral Reservoir: An Update. [PDF]
Obesity (Silver Spring)ABSTRACT Since the onset of the COVID‐19 pandemic, obesity has been consistently associated with worse clinical outcomes. In 2020, we hypothesized that adipose tissue (AT) might serve as a viral reservoir and amplifier of immune responses in SARS‐CoV‐2 infection. Five years on, accumulating evidence supports this hypothesis.
Maher LC, Ryan PM, Caplice NM.
europepmc +3 more sources
Optimization of Reservoir Waterflooding [PDF]
, 2014 Waterflooding is a common type of oil recovery techniques where water is pumped into the reservoir for increased productivity. Reservoir states change with time, as such, different injection and production settings will be required to lead the process
Grema, Alhaji Shehu
core +7 more sources
Contextualizing bats as viral reservoirs [PDF]
Science, 2020 Preventing zoonotic emergence from bats requires integrative ...
Streicker, Daniel G., Gilbert, Amy T.
openaire +2 more sources
Distinct viral reservoirs in individuals with spontaneous control of HIV-1 [PDF]
Nature, 2020 Rebecca Hoh, Tae-Wook Chun, Ben Rhee
exaly +2 more sources
Glycoengineering of AAV-delivered monoclonal antibodies yields increased ADCC activity
Molecular Therapy: Methods & Clinical Development, 2021 The absence of fucose on asparagine-297 of the human immunoglobulin G (IgG) heavy chain has been shown to enhance antibody-dependent cellular cytotoxicity (ADCC) activity by 10- to 100-fold compared to fucosylated antibody. Our lab is studying the use of
James M. Termini +4 more
doaj +1 more source
HIV-1 Infection of Long-Lived Hematopoietic Precursors In Vitro and In Vivo
Cells, 2022 Latent reservoirs in human-immunodeficiency-virus-1 (HIV-1)-infected individuals represent a major obstacle in finding a cure for HIV-1. Hematopoietic stem and progenitor cells (HSPCs) have been described as potential HIV-1 targets, but their roles as ...
Sebastian Renelt +11 more
doaj +1 more source