Results 11 to 20 of about 84,140 (293)

Viral and latent reservoir persistence in HIV-1-infected patients on therapy. [PDF]

PLoS Computational Biology, 2006
Despite many years of potent antiretroviral therapy, latently infected cells and low levels of plasma virus have been found to persist in HIV-infected patients. The factors influencing this persistence and their relative contributions have not been fully
Hwijin Kim, Alan S Perelson
doaj   +2 more sources

Qualitative plasma viral load determination as a tool for screening of viral reservoir size in PWH

AIDS, 2022
Objective(s): Suppression of viral replication in patients on antiretroviral therapy (ART) is determined by plasma viral load (pVL) measurement. Whenever pVL reaches values below the limit of quantification, the qualitative parameter ’target detected’ or ’target not detected’ is available but often not reported to the clinician.
Laeremans, Thessa, D'haese, Sigrid, Aernout, Jonathan, Barbé, Kurt, Pannus, Pieter, Rutsaert, Sofie, Vancutsem, Ellen, Vanham, Guido, Necsoi, Coca, Spiegelaere, Ward De, Couttenye, Marie, Herssens, Natacha, Scheerder, Marie-Angélique De, Wit, Stéphane De, Vandekerckhove, Linos, Eric, Florence, Aerts, Joeri L, Allard, Sabine D   +17 more
openaire   +5 more sources

The pathogenesis of zoonotic viral infections: Lessons learned by studying reservoir hosts [PDF]

Frontiers in Microbiology, 2023
Zoonotic viral infections that cause severe disease or even death in some people may be asymptomatic or mild in reservoir hosts. Comparison of the pathogenesis of these two host categories may potentially explain the difference in disease.
Lineke Begeman, Debby van Riel, Marion P. G. Koopmans, Marion P. G. Koopmans, Thijs Kuiken   +4 more
doaj   +2 more sources

Intact Proviral DNA Analysis of the Brain Viral Reservoir and Relationship to Neuroinflammation in People with HIV on Suppressive Antiretroviral Therapy. [PDF]

Viruses, 2023
HIV establishes a persistent viral reservoir in the brain despite viral suppression in blood to undetectable levels on antiretroviral therapy (ART). The brain viral reservoir in virally suppressed HIV+ individuals is not well-characterized. In this study,
Gabuzda D, Yin J, Misra V, Chettimada S, Gelman BB.   +4 more
europepmc   +2 more sources

Neuroinvasion and Viral Reservoir in COVID-19. [PDF]

Cureus, 2020
The new coronavirus disease 2019 (COVID-19) has a remarkably high transmissibility potential and sometimes invades the central nervous system (CNS). The study of the involvement of the nervous system in the pathogenesis of the disease is especially interesting.
Altable Pérez M, De la Serna JM.
europepmc   +4 more sources

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART [PDF]

Nature Communications, 2019
Here, Bachmann et al. provide data on long-term dynamics of the HIV-1 reservoir in 1,057 individuals on suppressive antiretroviral therapy and show that in 26.6% of individuals the reservoir increases.
Nadine Bachmann, Chantal von Siebenthal, Valentina Vongrad, Teja Turk, Kathrin Neumann, Niko Beerenwinkel, Jasmina Bogojeska, Jaques Fellay, Volker Roth, Yik Lim Kok, Christian W. Thorball, Alessandro Borghesi, Sonali Parbhoo, Mario Wieser, Jürg Böni, Matthieu Perreau, Thomas Klimkait, Sabine Yerly, Manuel Battegay, Andri Rauch, Matthias Hoffmann, Enos Bernasconi, Matthias Cavassini, Roger D. Kouyos, Huldrych F. Günthard, Karin J. Metzner, the Swiss HIV Cohort Study   +26 more
doaj   +2 more sources

HIV Persistence and Viral Reservoirs

, 2010
Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus type 1 (HIV-1), the virus is able to persist in cellular and anatomical viral reservoirs. Latently infected resting memory CD4+ T-cells are an important cellular reservoir, and the central nervous system (CNS) an important anatomical reservoir for ...
Edén, Arvid
openaire   +2 more sources

Contextualizing bats as viral reservoirs [PDF]

Science, 2020
Preventing zoonotic emergence from bats requires integrative ...
Streicker, Daniel G., Gilbert, Amy T.
openaire   +2 more sources

Intra-Host Evolution Analyses in an Immunosuppressed Patient Supports SARS-CoV-2 Viral Reservoir Hypothesis. [PDF]

Viruses
Throughout the SARS-CoV-2 pandemic, several variants of concern (VOCs) have been identified, many of which share recurrent mutations in the spike glycoprotein’s receptor-binding domain (RBD).
Fournelle D, Mostefai F, Brunet-Ratnasingham E, Poujol R, Grenier JC, Gálvez JH, Pagliuzza A, Levade I, Moreira S, Benlarbi M, Beaudoin-Bussières G, Gendron-Lepage G, Bourassa C, Tauzin A, Grandjean Lapierre S, Chomont N, Finzi A, Kaufmann DE, Craig M, Hussin JG.   +19 more
europepmc   +2 more sources

Confined aquifers as viral reservoirs [PDF]

Environmental Microbiology Reports, 2013
Summary Knowledge about viral diversity and abundance in deep groundwater reserves is limited. We found that the viral community inhabiting a deep confined aquifer in S outh A ustralia was more similar to reclaimed water communities ...
Smith, Renee J, Jeffries, Thomas, Roudnew, Ben, Seymour, Justin, Fitch, Alison J, Simons, Keryn Leah, Speck, Peter Gerald, Newton, Kelly, Brown, Melissa Hackett, Mitchell, James Gordon   +9 more
openaire   +3 more sources