Results 31 to 40 of about 88,749 (308)

Tropism prediction in HIV-1 variants circulating in Cuba, 2017-2019: Implications for the pathogenesis of infection and response to Maraviroc

Journal of Microbiology and Infectious Diseases, 2023
Background: Tropism is determined by the ability of HIV-1 to bind to the receptors CCR5 or CXCR4 to enter the target cell, which has implications for the pathogenesis of the disease and affects treatment options.
Anamary Suarez Batista, Lissette Perez Santos, Liuber Yans Machado Zaldívar, Melissa Mendez Gonzalez, Yanet Pintos Saavedra, Jorge Perez Ávila, Hector Manuel Díaz Torres, Tamara Rojas Nuñez, Juliet María Enriquez Puertas, Yoanna Baños Morales, Enrique Noa Romero, Vivian Kourí Cardella   +11 more
doaj   +1 more source

AMD3100/CXCR4 Inhibitor [PDF]

Frontiers in Immunology, 2015
The original bicyclam, JM1657 (JM standing for Johnson Matthey) was discovered as a contaminant in a commercial preparation of monocyclams when evaluated for their anti-HIV activity. The original compound, in which the cyclam rings were tethered by a C–C linkage could not be re-synthesized but launched the synthesis of new bicyclams in which the cyclam
openaire   +4 more sources

Deletion of SDF-1 or CXCR4 regulates platelet activation linked to glucose metabolism and mitochondrial respiratory reserve

Platelets, 2022
Stromal cell-derived factor 1 (SDF-1, also known as CXCL12) and its receptor CXCR4 have shown to play a role in the homing and engraftment of hematopoietic stem and progenitor cells.
Yi Li, Ziqian Feng, Luochen Zhu, Ni Chen, Qin Wan, Jianbo Wu   +5 more
doaj   +1 more source

Widespread CXCR4 Activation in Astrocytomas Revealed by Phospho-CXCR4-Specific Antibodies [PDF]

Cancer Research, 2005
Abstract The chemokine receptor CXCR4 is expressed in many cancers where it may regulate tumor cell growth and migration. The role of CXCR4 in cancer will depend on it being in an activated, signaling state. To better define the significance of CXCR4 expression in cancer, we developed an antibody that can distinguish CXCR4 ...
B Mark, Woerner, Nicole M, Warrington, Andrew L, Kung, Arie, Perry, Joshua B, Rubin   +4 more
openaire   +2 more sources

CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS

Сибирский онкологический журнал, 2018
The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and
O. E. Savelieva, L. A. Tashireva, M. A. Buldakov, R. H. Mukhamedzhanov, E. V. Kaigorodova, E. V. Denisov, M. V. Zavyalova, V. M. Perelmuter   +7 more
doaj   +1 more source

[68Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants [PDF]

Asia Oceania Journal of Nuclear Medicine and Biology, 2023
[68Ga] Ga-labeled C-X-C motif receptor4 as a novel radio-ligand using PET/CT has been investigated for tracing various kinds of solid and hematopoietic malignancies in recent years.
Hessamoddin Roustaei, Emran Askari, Somayeh Barashki, Kazem Anvari, Ramin Sadeghi, Kamran Aryana   +5 more
doaj   +1 more source

The biology of CCR5 and CXCR4 [PDF]

Current Opinion in HIV and AIDS, 2009
We discuss the current knowledge concerning the biology of CXCR4 and CCR5 and their roles in HIV-1 infection.Important research findings reported in the last 2 years have advanced our knowledge in the field of HIV coreceptors and pathogenesis. Novel methods have been used to crystallize two new members of the G-protein coupled receptors.
openaire   +2 more sources

Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration [PDF]

, 2009
FLT3-ITD-mediated leukemogenesis is associated with increased expression of oncogenic PIM serine/threonine kinases. To dissect their role in FLT3-ITD-mediated transformation, we performed bone marrow reconstitution assays.
Spoo, A, Bullock, AN, Spoo, Anke Cornelia, Duyster, Justus, Pogacic, Vanda, Dechow, Tobias, Andrea Biondi, Grundler, R, Sabine Ehret, Spoo, Anke, Vanda Pogacic, Anke Spoo, Bullock, Alex N., Villa, A, Pogacic, V, Ehret, S, Georgina Berridge, Knapp, S, Dechow, T, Berridge, G, Tobias Dechow, Juerg Schwaller, Christine Dierks, Grundler, Rebekka, Schwaller, J, Duyster, J, Laurent Brault, Bullock, Alexander, Woetzel, S, Antonello Villa, Dierks, Christine, Brault, Laurent, Stefan Knapp, Justus Duyster, Villa, Antonello, Gasser, C, Gasser, Christelle, Rebekka Grundler, Biondi, A, Sabine Woetzel, Brault, L, Woetzel, Sabine, Knapp, Stefan, Schwaller, Juerg, Biondi, Andrea, Dierks, C, Alex N. Bullock, Christelle Gasser, Ehret, Sabine, Wötzel, Sabine, Berridge, Georgina   +50 more
core   +1 more source

CXCR4-Based Imaging Agents [PDF]

Journal of Nuclear Medicine, 2011
Chemokine receptor 4 (CXCR4)-chemokine ligand 12 (CXCL12) interactions have been shown to play key roles in cancer cell survival, proliferation, chemotaxis, homing, adhesion, tumor angiogenesis, and resistance to conventional and targeted therapies.
Lauren E, Woodard, Sridhar, Nimmagadda
openaire   +2 more sources

Upregulation of surface feline CXCR4 expression following ectopic expression of CCR5: implications for studies of the cell tropism of feline immunodeficiency virus [PDF]

, 2002
Feline CXCR4 and CCR5 were expressed in feline cells as fusion proteins with enhanced green fluorescent protein (EGFP). Expression of the EGFP fusion proteins was localized to the cell membrane, and surface expression of CXCR4 was confirmed by using a ...
Hosie, M.J., Willett, B.J., Cannon, C.A.
core   +1 more source