Results 31 to 40 of about 94,110 (297)
Targeting CXCR4 in AML and ALL [PDF]
Frontiers in Oncology, 2020 The interaction of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) blasts with the bone marrow microenvironment regulates self-renewal, growth signaling, as well as chemotherapy resistance. The chemokine receptor, CXC receptor 4 (CXCR4), with its ligand chemokine ligand 12 (CXCL12), plays a key role in the survival and migration of ...
Cancilla, Daniel +2 more
openaire +4 more sources
The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus [PDF]
, 1999 Infection with feline immunodeficiency virus (FIV) leads to the development of a disease state similar to AIDS in man. Recent studies have identified the chemokine receptor CXCR4 as the major receptor for cell culture-adapted strains of FIV, suggesting ...
Hosie, M.J. +3 more
core +1 more source
Cells, 2020 The serine/threonine protein kinase AKT1 is a downstream target of the chemokine receptor 4 (CXCR4), and both proteins play a central role in the modulation of diverse cellular processes, including proliferation and cell survival.
Elke Butt +12 more
doaj +1 more source
The Role of CXCL12 in Kidney Diseases: A Friend or Foe?
Kidney Diseases, 2021 Background: Chemokines are a family of proteins mainly mediating the homing and migration of various cells. The CXC chemokine CXCL12 is a member of low-weight-molecular chemokines.
Anni Song +3 more
doaj +1 more source
Histone deacetylase inhibitors induce CXCR4 mRNA but antagonize CXCR4 migration [PDF]
Cancer Biology & Therapy, 2013 The stromal cell-derived factor-1α SDF-1α (CXCL12)/CXCR4 axis has been linked to poor prognosis in some cancers. As histone deacetylase inhibitors (HDIs) exert antitumor effects by targeting proteins affecting cell migration, we sought to evaluate the effects of the HDIs apicidin, vorinostat, entinostat (MS-275) and romidepsin on the expression and ...
Caterina, Ierano +7 more
openaire +2 more sources
C-X-C Motif Chemokine Receptor 4 (CXCR4)-Targeted Biologically Guided Proton Spatially Fractionated Radiotherapy for Bulky Limited-Stage Small Cell Lung Cancer. [PDF]
Precis Radiat OncolA newly proposed proton spatially fractionated radiotherapy guided by biological imaging Abstract Background and Purpose To evaluate the feasibility and dosimetric safety of integrating C–X–C motif chemokine receptor 4 (CXCR4)‐targeted tracer 18F‐AlF‐NOTA‐QHY‐04 positron emission tomography imaging with biologically guided proton spatially fractionated
Pu K +7 more
europepmc +2 more sources
Widespread CXCR4 Activation in Astrocytomas Revealed by Phospho-CXCR4-Specific Antibodies [PDF]
Cancer Research, 2005 Abstract The chemokine receptor CXCR4 is expressed in many cancers where it may regulate tumor cell growth and migration. The role of CXCR4 in cancer will depend on it being in an activated, signaling state. To better define the significance of CXCR4 expression in cancer, we developed an antibody that can distinguish CXCR4 ...
B Mark, Woerner +4 more
openaire +2 more sources
Viruses, 2019 SHIV variants KB9 and 89.6 show differential pathogenesis in primate models with KB9 causing rapid CD4 decline while 89.6 failing to induce disease.
Tugba Mehmetoglu-Gurbuz +2 more
doaj +1 more source
Synthesis & Evaluation Of Thiophene Derivatives As CXCR4 Antagonists [PDF]
, 2018 There is a lack of good CXCR4 inhibitors that treat cancer cell metastasis and autoimmune diseases without serious drawbacks. AMD3100 and WZ811 are the CXCR4 antagonists that were the initial structural basis for our new potential therapeutics. Molecular
Garcia, Francisco Javier
core +1 more source
Di-san junyi daxue xuebao, 2020 Objective To prepare targeted ultrasonic nanobubbles carrying small-molecule CXCR4 antagonist AMD070, which can be used in integrated diagnosis and treatment, and investigate the binding ability to breast cancer cells in vitro, in order to investigate ...
SHEN Daijia +5 more
doaj +1 more source