Results 31 to 40 of about 131,312 (209)

What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands [PDF]

, 2019
Dipeptidyl peptidase 4 (DPP4) is an exopeptidase found either on cell surfaces where it is highly regulated in terms of its expression and surface availability (CD26) or in a free/circulating soluble constitutively available and intrinsically active form.
Aguilar-Pérez, Alexandra, Awad, Mohamed E., Eisa, Nada H., Elmansi, Ahmed M., Fulzele, Sadanand, Hamrick, Mark W., Herberg, Samuel, Hill, William D., Hussein, Khaled A., Isales, Carlos M., Kondrikov, Dmitry, McGee-Lawrence, Meghan E., Periyasamy-Thandavan, Sudharsan, Volkman, Brian F.   +13 more
core   +1 more source

Chronic inflammation evoked by pathogenic stimulus during carcinogenesis

4 open, 2019
A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Accelerated in vivo proliferation of memory phenotype CD4+ T-cells in human HIV-1 infection irrespective of viral chemokine co-receptor tropism. [PDF]

, 2013
CD4(+) T-cell loss is the hallmark of HIV-1 infection. CD4 counts fall more rapidly in advanced disease when CCR5-tropic viral strains tend to be replaced by X4-tropic viruses.
A Kaur, A Llano, A Yates, AN Phillips, Andrea Hegedus, Andrew Worth, B Asquith, Catherine de Lara, D Berhanu, Daniel C. Douek, DC Douek, DC Douek, DC Macallan, DC Macallan, DC Macallan, DC Macallan, DD Ho, Derek Macallan, DL Wallace, EJ Heeregrave, HC Lane, I den Braber, J Embretson, JM Brenchley, JM McCune, JV Giorgi, K Ladell, Karoliina Laamanen, L Cicin-Sain, LJ Picker, M Catalfamo, M Hellerstein, M Koot, MD Hazenberg, MK Hellerstein, MP Davenport, N Brieu, N Vrisekoop, Peter Beverley, R Busch, R Shankarappa, RJ De Boer, RJ De Boer, RM Ribeiro, RM Ribeiro, RS Veazey, SA Handley, TW Chun, V Sanchez, Yan Zhang   +49 more
core   +3 more sources

Drug resistance and viral tropism in HIV-1 subtype C-infected patients in KwaZulu-Natal, South Africa: implications for future treatment options [PDF]

, 2011
Article approval pendingDrug resistance poses a significant challenge for the successful application of highly active antiretroviral therapy (HAART) globally. Furthermore, emergence of HIV-1 isolates that preferentially use CXCR4 as a coreceptor for cell
Ashika Singh, Bjorndal, Brenner, Briggs, Briz, Cann, Cecilia, Cilliers, Coakley, Coetzer, Connor, Cozzi-Lepri, Daniel R. Kuritzkes, Elizabeth D. Anton, Fouchier, Fouchier, Furtado, Henry Sunpath, Hosseinipour, Hunt, Irlbeck, Jacqueline D. Reeves, Johnston, Kantor, Keshni Hiramen, Kuiken, Loemba, Low, Marconi, Nagavelli Padayachi, Ndungu, Novitsky, Reeves, Richard Murphy, Rizzuto, Scarlatti, Singh, Tamura, Taryn N. Green, Taylor, Thumbi Ndung'u, Tobin, Trinh, Tscherning, Wallis, Westby, Whitcomb, Wu, Yolanda Lie   +48 more
core   +2 more sources

Regulation of CXCR4 signaling

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007
The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors, and is directly involved in a number of biological processes including organogenesis, hematopoiesis, and immune response. Recent evidence has highlighted the role of CXCR4 in a variety of diseases including HIV, cancer, and WHIM syndrome.
Busillo, John M., Benovic, Jeffrey L.
openaire   +2 more sources

Does the Chemotherapy Protocol Affect CXCL12/CXCR4 Axes in Acute Myeloid Leukemia Patients with Monocytic Differentiation? [PDF]

Middle East Journal of Cancer, 2022
Background: The CXCR4 receptor along with CXCL12 is believed to have an effect on the onset, progression, migration, and treatment complications and improve acute myeloid leukemia (AML) treatment outcomes.
Bahar Yazdani, Zahra Mousavi, Mohsen Ehsan, Behjat Kalantary Khandany, Gholamhossein Hassanshahi   +4 more
doaj   +1 more source

Essential Role of Lyn in Fibrosis. [PDF]

, 2016
Fibrotic disorders involve replacement of normal parenchyma with myofibroblasts, which deposit connective tissue, leading to obliteration of the function of the underlying organ.
Birtolo, Chiara, Chheda, Chintan, Cirulli, Vincenzo, Gugliotta, Gabriele, Lewis, Michael S, Liu, Sandy T, Pandol, Stephen J, Pham, Hung, Ptasznik, Andrzej, Rodriguez, Maria D, Yang, Wendy   +10 more
core   +2 more sources

CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry

Biochemical Pharmacology, 2018
The chemokine receptor CXCR4 and its ligand CXCL12 contribute to a variety of human diseases, such as cancer. CXCR4 is also a major co-receptor facilitating HIV entry. Accordingly, CXCR4 is considered as an attractive therapeutic target. Drug side effects and poor pharmacokinetic properties have been major hurdles that have prevented the implementation
Van Hout, Anneleen, Klarenbeek, Alex, Bobkov, Vladimir, Doijen, Jordi, Arimont, Marta, Zhao, Chunxia, Heukers, Raimond, Rimkunas, Rebecca, de Graaf, Chris, Verrips, Theo, van der Woning, Bas, de Haard, Hans, Rucker, Joseph B., Vermeire, Kurt, Handel, Tracy, Van Loy, Tom, Smit, Martine J., Schols, Dominique   +17 more
openaire   +3 more sources

Stromal Cell-Derived Factor 1 Protects Brain Vascular Endothelial Cells from Radiation-Induced Brain Damage

Cells, 2019
Stromal cell-derived factor 1 (SDF-1) and its main receptor, CXC chemokine receptor 4 (CXCR4), play a critical role in endothelial cell function regulation during cardiogenesis, angiogenesis, and reendothelialization after injury. The expression of CXCR4
Jong-Ik Heo, Kwang Il Kim, Sang-Keun Woo, Joong Sun Kim, Kyu Jin Choi, Hae-June Lee, Kwang Seok Kim   +6 more
doaj   +1 more source

A Theoretical Mechanism for the Action of SONG-Modulated Laser Light on Human Very Small Embryonic-Like (hVSEL) Stem Cells in Platelet Rich Plasma (PRP) [PDF]

CellR4, 2021
It has previously been shown that human very small embryonic-like (hVSEL) stem cell proliferation occurs rapidly when hVSEL stem cells in platelet rich plasma (PRP) are exposed to Strachan Ovokaitys Node Generator (SONG)-modulated laser light.
J. Brindley, P. Hollands, T. Ovokaitys
doaj   +1 more source