Results 51 to 60 of about 94,110 (297)

“The potential role of CXCR4 and SDF-1 as indicators of tumor aggressiviness in patients with conventional papillary thyroid carcinoma” [PDF]

, 2008
Background: Functional chemokine receptors are expressed in many malignant tumors, including papillary thyroid carcinoma (PTC). These receptors promote tumor growth and metastasis in response to endogenous chemokines.
Pagano, Loredana
core   +1 more source

Tropism prediction in HIV-1 variants circulating in Cuba, 2017-2019: Implications for the pathogenesis of infection and response to Maraviroc

Journal of Microbiology and Infectious Diseases, 2023
Background: Tropism is determined by the ability of HIV-1 to bind to the receptors CCR5 or CXCR4 to enter the target cell, which has implications for the pathogenesis of the disease and affects treatment options.
Anamary Suarez Batista, Lissette Perez Santos, Liuber Yans Machado Zaldívar, Melissa Mendez Gonzalez, Yanet Pintos Saavedra, Jorge Perez Ávila, Hector Manuel Díaz Torres, Tamara Rojas Nuñez, Juliet María Enriquez Puertas, Yoanna Baños Morales, Enrique Noa Romero, Vivian Kourí Cardella   +11 more
doaj   +1 more source

CXCR4-[P2G]CXCL12 intermolecular crosslinking efficiencies detected by flow cytometry.

, 2020
(A) A heat map of pairwise cross-linking efficiencies in the predicted CRS0.5, normalized to CXCR4(D187C)-vMIP-II(W5C), a previously crystallized covalent complex.
Tony Ngo (5072279), Lauren G. Holden (2417851), Irina Kufareva (379208), Tracy M. Handel (245262), Bryan S. Stephens (8694645), Ruben Abagyan (220938), Martin Gustavsson (1465012)   +6 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evaluation of C-X-C chemokine receptor type 4 (CXCR4) and Peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in colorectal carcinoma: Relation to the available clinicopathological parameters

Indian Journal of Pathology and Microbiology, 2023
Background: Colorectal carcinoma (CRC) is the most common malignancy of the gastrointestinal tract, representing an incredible health problem. It is essential to develop drugs against novel targets––involved in CRC tumorigenesis and progression––to ...
Asmaa E. Bedeer, Nehal Abd El-Ghaffar Heabah   +1 more
doaj  

Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12 [PDF]

, 2012
Chemokines and their ligands play a critical role in enabling chronic lymphocytic leukaemia (CLL) cells access to protective microenvironmental niches within tissues, ultimately resulting in chemoresistance and relapse: disruption of these signaling ...
McCaig, Alison M., Alison M McCaig, Alison M. Mccaig, Cosimo Emilio, Alison M. Michie, Leach Michael T., Alison M Michie, Emilio Cosimo, Michael T. Leach, McCaig Alison M., Michael T Leach, Michie, Alison M., Michie Alison M., Cosimo, Emilio, Leach, Michael T.   +14 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

CXCR7 functions as a scavenger for CXCL12 and CXCL11. [PDF]

, 2010
CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is
Pruenster, M, Mahabaleshwar, Harsha, Ulrike Naumann, Raz Erez, Rot, Antal, Rot Antal, Marcus Thelen, Naumann, U, Zerwes Hans-Günter, Harsha Mahabaleshwar, Naumann Ulrike, Cameroni, E, Mahabaleshwar, H, Elisabetta Cameroni, Zerwes, Hans-Günter, Raz, E, Pruenster Monika, Mahabaleshwar Harsha, Monika Pruenster, Hans-Günter Zerwes, Pruenster, Monika, Thelen, M, Thelen Marcus, Naumann, Ulrike, Cameroni, Elisabetta, Cameroni Elisabetta, Raz, Erez, Zerwes, HG, Antal Rot, Erez Raz, Thelen, Marcus   +30 more
core   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Differential expression of SDF-1 receptor CXCR4 in molecularly defined forms of inherited thrombocytopenias

Platelets, 2017
The SDF-1-CXCR4 axis plays an essential role in the regulation of platelet production, by directing megakaryocyte (MK) migration toward the vascular niche, thus allowing terminal maturation and proplatelet formation, and also regulates platelet function ...
Juan P. Salim, Ana C. Glembotsky, Paola R. Lev, Cecilia P. Marin Oyarzún, Nora P. Goette, Felisa C. Molinas, Rosana F. Marta, Paula G. Heller   +7 more
doaj   +1 more source