Results 61 to 70 of about 94,110 (297)

CXCR4 signaling regulates metastatic onset by controlling neutrophil motility and response to malignant cells. [PDF]

, 2019
Developing tumors interact with the surrounding microenvironment. Myeloid cells exert both anti- and pro-tumor functions and chemokines are known to drive immune cell migration towards cancer cells.
Stefanescu, C, Tulotta, C, Torraca, V, Torraca, V., Snaar-Jagalska, B.E., Chen, Q., Tulotta, C., Chen, Q, Annemarie Meijer, Meijer, AH, Meijer, A.M., Snaar-Jagalska, BE, Stefanescu, C., Meijer, A.H.   +13 more
core   +1 more source

CXCR4 as a novel target in immunology: moving away from typical antagonists [PDF]

, 2022
CXCR4 has been a target of interest in drug discovery for numerous years. However, so far, most if not all studies focused on finding antagonists of CXCR4 function.
Milligan, Graeme, Armelle Melet, Van Emelen, Kristof, Birgit Caspar, Jean-Philippe Herbeuval, Caspar, Birgit, Melet, Armelle, Cocchiara, Pietro, Herbeuval, Jean-Philippe, Annegret Van der Aa, Van der Aa, Annegret, Graeme Milligan, Pietro Cocchiara, Kristof Van Emelen   +13 more
core   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Inflammatory signaling of HMGB1 in depressive disorder

Stress and Brain, 2023
Background:Depressive disorder is a common disease characterized by depressed mood and loss of pleasure, which often brings a great grief to patients and a huge burden to the society.
Qian Jiang, Chaoran Li, Huijing Xu, Taosheng Liu, Yunxia Wang   +4 more
doaj   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

CXCR4 expression in vitreoretinal membranes [PDF]

British Journal of Ophthalmology, 2003
Proliferative vitreoretinopathy (PVR) and macular pucker (MP) vitreoretinal membranes are caused by abnormal cell migration. By their role in chemotactism, chemokine receptors represent good candidates to sustain this process. The authors thus investigated the expression of one of them, CXCR4, in these pathologies.Three PVR and four MP membranes were ...
Cabay, Laurence, Willermain, Francois, Bruyns, Catherine, Verdebout, Jean-Marc, Witta, Y., Baffi, J., Velu, Thierry, Libert, Jacques, Caspers, Laure, Maho, Arielle, Lespagnard, Laurence   +10 more
openaire   +3 more sources

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

A focus on CXCR4 in Alzheimer's disease [PDF]

Brain Circulation, 2017
Alzheimer's disease (AD) is one of the most common and devastating aging-related neurodegenerative diseases. Besides the well-known role of chemokines and their receptors in the immune system, they are widely expressed in the nervous system, where they play roles in the regulation of cell migration and neurotransmission.
Hongyan Li, Rong Wang
openaire   +3 more sources

SDF1 Gene Variation Is Associated with Circulating SDF1 alpha Level and Endothelial Progenitor Cell Number-The Bruneck Study [PDF]

, 2008
BACKGROUND: Stromal cell-derived factor-1 (SDF1) and its receptor CXC chemokine receptor 4 (CXCR4) play a critical role in progenitor cell homing, mobilization and differentiation.
Marjan Jahangiri, Kiechl, Stefan, Mayr, A, Willeit, J, Qingzhong Xiao, Friedrich Oberhollenzer, Xu Qingbo, Jahangiri, M, Ye Shu, Oberhollenzer Friedrich, Jahangiri, Marjan, Willeit Johann, Mayr, Agnes, Oberhollenzer, F, Mayr Agnes, Willeit, Johann, Ye, Shu, Xiao, Q, Ye, S, Kiechl, S, Kiechl Stefan, Xu, Q, Jahangiri Marjan, Stefan Kiechl, Qingbo Xu, Xiao Qingzhong, Johann Willeit, Oberhollenzer, Friedrich, Xu, Qingbo, Shu Ye, Agnes Mayr, Xiao, Qingzhong   +31 more
core   +2 more sources

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source