Results 81 to 90 of about 131,312 (209)

New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools [PDF]

, 2019
BACKGROUND: Ovarian cancer is the leading cause of gynecologic cancer-related death, due in part to a late diagnosis and a high rate of recurrence. Primary and acquired platinum resistance is related to a low response probability to subsequent lines of ...
Carnero Moya, Amancio, Domínguez Piñol, Julia, Espinosa Sánchez, Asunción, Felipe Abrio, Blanca, García Carrasco, Miguel, García Heredia, José Manuel, Muñoz Galván, Sandra, Navas Maldonado, Lola Eufemia, Otero Abiol, Daniel, Suarez Martínez, Elisa, Verdugo Sivianes, Eva María   +10 more
core   +1 more source

Comparison of 18F-labeled CXCR4 antagonist peptides for PET imaging of CXCR4 expression [PDF]

Molecular Imaging and Biology, 2013
CXCR4 is overexpressed on tumor cells from many types of human cancers. A high level of CXCR4 expression often correlates with poor prognosis, chemotherapy resistance, and metastasis. The development of CXCR4-specific radiotracers for positron emission tomography (PET) imaging will allow in vivo evaluation of receptor expression level for diagnosis or ...
Zhang, Xiao-Xiang, Sun, Zhongchan, Guo, Jinxia, Wang, Zhe, Wu, Chenxi, Niu, Gang, Ma, Ying, Kiesewetter, Dale O., Chen, Xiaoyuan   +8 more
openaire   +3 more sources

MicroRNA-301a knockout attenuates peripheral nerve regeneration by delaying Wallerian degeneration

Neural Regeneration Research
Our recent study demonstrated that knockout of microRNA-301a attenuates migration and phagocytosis in macrophages. Considering that macrophages and Schwann cells synergistically clear the debris of degraded axons and myelin during Wallerian degeneration,
Lanya Fu, Xiaofang Hu, Jiawei Xu, Zhenlin Li, Jiale Cai, Xinrui Ma, Ying Zou, Ye He, Shuyi Xu, Yizhou Xu, Jiaqi Zhang, Yunlun Li, Jingmin Liu, Tsz Hei Fong, Xianghai Wang, Lixin Zhu, Dongfeng Chen, Aijun Liu, Xiaodong Ma, Jiasong Guo   +19 more
doaj   +1 more source

An enhanced CRISPR repressor for targeted mammalian gene regulation. [PDF]

, 2018
The RNA-guided endonuclease Cas9 can be converted into a programmable transcriptional repressor, but inefficiencies in target-gene silencing have limited its utility.
Cecchi, Ryan J, Chan, Yingleong, Chavez, Alejandro, Church, George M, Church, George M, Collins, James J, Davidsohn, Noah, Ebrahimkhani, Mo R, Guo, Xiaoge, Kiani, Samira, Kuo, Chih-Chung, Lance-Byrne, Alissa, Lewis, Nathan E, Lim, Elaine T, Menn, David, Milanova, Denitsa, Pradhan, Swechchha, Sharma, Sumana, Tung, Angela, Tuttle, Marcelle, Yeo, Nan Cher   +20 more
core   +1 more source

Halting metastasis through CXCR4 inhibition

Bioorganic & Medicinal Chemistry Letters, 2013
Metastasis occurs when cancer cells leave the primary tumor site and migrate to distant parts of the body. The CXCR4-SDF-1 pathway facilitates this migration, and its expression has become the hallmark of several metastatic cancers. Targeted approaches are currently being developed to inhibit this pathway, and several candidates are now in clinical ...
Ramsey, DM, McAlpine, S
openaire   +3 more sources

Differential expression of SDF-1 receptor CXCR4 in molecularly defined forms of inherited thrombocytopenias

Platelets, 2017
The SDF-1-CXCR4 axis plays an essential role in the regulation of platelet production, by directing megakaryocyte (MK) migration toward the vascular niche, thus allowing terminal maturation and proplatelet formation, and also regulates platelet function ...
Juan P. Salim, Ana C. Glembotsky, Paola R. Lev, Cecilia P. Marin Oyarzún, Nora P. Goette, Felisa C. Molinas, Rosana F. Marta, Paula G. Heller   +7 more
doaj   +1 more source

The role of platelet microvesicles in intercellular communication. [PDF]

, 2016
In recent years, there has been exponential growth in the interest in microvesicles, which is reflected by the number of publications. Initially referred to as platelet dust by Peter Wolf in 1967, platelet microvesicles (PMV) are now recognized as ...
Edelstein, Leonard C.
core   +2 more sources

Calcineurin/CXCR4 in T-ALL

Oncoscience, 2015
The calcineurin/NFAT signaling pathway is implicated in a wide variety of biological processes, acting as a bridge pathway between calcium signals and gene expression. Although its role as an effector of immune responses figured prominently in early studies, it forms just one part of a larger picture. Indeed calcineurin has been shown to participate in
Diana, Passaro, Christine Tran, Quang, Jacques, Ghysdael   +2 more
openaire   +2 more sources

Chemokine-induced secretion of gelatinase B in primary human monocytes [PDF]

, 2001
Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited ...
Brew K., Grone H. J., Luboshits G., Nagase H., Stetler-Stevenson W. G., Stetler-Stevenson W. G., Urdiales-Viedma M., Zhang Y.   +7 more
core   +1 more source

Mechanistic study of novel arylpiperazine derivative NAF19 in prostate cancer treatment based on network pharmacology approach

Romanian Journal of Laboratory Medicine
Our preliminary studies identified the arylpiperazine derivative NAF19 as a promising therapeutic agent against prostate cancer, though its precise mechanisms remained unclear.
Jiang Hua, Xu Mingzhen, Jiang Songsong, Huang Weiqiang, Chen Hong   +4 more
doaj   +1 more source