Results 71 to 80 of about 88,749 (308)

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

Advanced Functional Materials, EarlyView.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim, Seong‐Jin Shin, Sak Lee, Nandin Mandakhbayar, Ji‐Hye Kang, Da‐Young Kong, Seong‐Doo Hong, Ueon Sang Shin, Hae‐Won Kim, Jung‐Hwan Lee   +9 more
wiley   +1 more source

Differential Pathogenicity of SHIV KB9 and 89.6 Env Correlates with Bystander Apoptosis Induction in CD4+ T cells

Viruses, 2019
SHIV variants KB9 and 89.6 show differential pathogenesis in primate models with KB9 causing rapid CD4 decline while 89.6 failing to induce disease.
Tugba Mehmetoglu-Gurbuz, Anjali Joshi, Himanshu Garg   +2 more
doaj   +1 more source

CXCR4 expression in vitreoretinal membranes [PDF]

British Journal of Ophthalmology, 2003
Proliferative vitreoretinopathy (PVR) and macular pucker (MP) vitreoretinal membranes are caused by abnormal cell migration. By their role in chemotactism, chemokine receptors represent good candidates to sustain this process. The authors thus investigated the expression of one of them, CXCR4, in these pathologies.Three PVR and four MP membranes were ...
Cabay, Laurence, Willermain, Francois, Bruyns, Catherine, Verdebout, Jean-Marc, Witta, Y., Baffi, J., Velu, Thierry, Libert, Jacques, Caspers, Laure, Maho, Arielle, Lespagnard, Laurence   +10 more
openaire   +3 more sources

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Preparation of targeted nanobubbles carrying AMD070 and its inhibitory effect on growth of breast cancer cells in vitro

Di-san junyi daxue xuebao, 2020
Objective To prepare targeted ultrasonic nanobubbles carrying small-molecule CXCR4 antagonist AMD070, which can be used in integrated diagnosis and treatment, and investigate the binding ability to breast cancer cells in vitro, in order to investigate ...
SHEN Daijia, ZHU Lianhua, LIU Yu, FANG Kejing, LIU Deng, GUO Yanli   +5 more
doaj   +1 more source

A focus on CXCR4 in Alzheimer's disease [PDF]

Brain Circulation, 2017
Alzheimer's disease (AD) is one of the most common and devastating aging-related neurodegenerative diseases. Besides the well-known role of chemokines and their receptors in the immune system, they are widely expressed in the nervous system, where they play roles in the regulation of cell migration and neurotransmission.
Hongyan Li, Rong Wang
openaire   +3 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

C-X-C motif chemokine ligand 12—C-X-C chemokine receptor type 4 signaling axis in cancer and the development of chemotherapeutic molecules

Tzu Chi Medical Journal
Chemokines are small, secreted cytokines crucial in the regulation of a variety of cell functions. The binding of chemokine C-X-C motif chemokine ligand 12 (CXCL12) (stromal cell-derived factor 1) to a G-protein-coupled receptor C-X-C chemokine receptor ...
Jui-Hung Yen, Chun-Chun Chang, Hao-Jen Hsu, Chin-Hao Yang, Hemalatha Mani, Je-Wen Liou   +5 more
doaj   +1 more source

Mechanisms underlying the improvement of preeclampsia through salvianolic acid B-regulated miRNA-155/CXCR4

Archives of Medical Science, 2020
Introduction The aim of this study was to evaluate the effects and mechanisms of salvianolic acid B (Sal B) in preeclampsia treatment by in vivo and in vitro study. Material and methods Rats were randomly divided into 5 groups. In order to establish the
Chuanlian Zhang, Xue Han, Xiaoxue Wang
doaj   +1 more source

The Intricate Role of CXCR4 in Cancer [PDF]

, 2014
Chemokines mediate numerous physiological and pathological processes related primarily to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived factor-1, binds the G-protein-coupled receptor CXCR4, which, through multiple divergent pathways, leads to chemotaxis, enhanced intracellular calcium, cell adhesion, survival ...
Samit, Chatterjee, Babak, Behnam Azad, Sridhar, Nimmagadda   +2 more
openaire   +2 more sources