Development and Validation of a Radiochemical Purity Determination Method for [68Ga]Ga-DOTA-CXCR4-D1
Journal of IsotopesCXCR4 is a chemokine receptor widely overexpressed on the surface of various tumor cells. Given its pivotal role in tumor invasion，metastasis，and recurrence，it has emerged as a key target in molecular imaging.
Jingjing YU +8 more
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CXCR4 pos circulating progenitor cells coexpressing monocytic and endothelial markers correlating with fibrotic clinical features are present in the peripheral blood of patients affected by systemic sclerosis [PDF]
, 2008 There is still controversy regarding the role of circulating endothelial and progenitor cells (CECs/CEPs) in the pathogenesis of systemic sclerosis (SSc).
CAMPIONI, Diana +8 more
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Stem-cell-based gene therapy for HIV infection. [PDF]
, 2013 Despite the enormous success of combined anti-retroviral therapy, HIV infection is still a lifelong disease and continues to spread rapidly worldwide. There is a pressing need to develop a treatment that will cure HIV infection.
Kitchen, Scott, Zhen, Anjie
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Romanian Journal of Laboratory MedicineBackground: The aim of this study was to investigate the activation of the C-X-C chemokine receptor type 4 (CXCR4)/Akt signaling pathway in the peripheral blood of individuals diagnosed with brain glioma and assess its potential as a predictive marker.
Zou Xueli
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Understanding the process of envelope glycoprotein incorporation into virions in simian and feline immunodeficiency viruses [PDF]
, 2014 The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis.
Affranchino, Jose Luis +1 more
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International Journal of General MedicineDanChan Huang,1 DanXia Lin,2 SiXian Liang,2 Jing Lin1 1Department of Oncology, The First Affiliated Hospital of Shantou University Medical College, Shantou City, Guangdong Province, 515000, People’s Republic of China; 2Department of Breast Oncology ...
Huang D, Lin D, Liang S, Lin J
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Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms [PDF]
, 2018 Platelet-activating factor (PAF) stimulates numerous cell types via activation of the G protein-coupled PAF receptor (PAFR). PAFR activation not only induces acute proinflammatory responses, but it also induces delayed systemic immunosuppressive effects ...
FitzGerald, Garret A. +6 more
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CXCR4 for CNS infections [PDF]
Science-Business eXchange, 2008 Washington University School of Medicine researchers have used Genzyme's Mozobil (AMD3100) to demonstrate that antagonizing CXC chemokine receptor 4 could be a strategy for viral encephalitis. This may provide new indications for Genzyme and other companies developing CXCR4 antagonists, but potential issues with autoimmunity loom on the horizon.
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Journal of Inflammation Research, 2022 Qixian Sun,1 Xinrong Tao,1– 4 Bing Li,1 Hangbing Cao,1 Haoming Chen,1 Yuanjie Zou,1 Huihui Tao,1– 4 Min Mu,1– 4 Wenyang Wang,1 Keyi Xu1– 4 1Center for Medical Research, Medical School, Anhui University of Science and Technology, Huainan, People’s ...
Sun Q +9 more
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Bioinformatically analyzed relationships between specific human genes associated with HIV attachment
Инфекция и иммунитетIntroduction. Assessing interaction between the human immunodeficiency virus (HIV) and human factors is crucial for understanding the disease pathogenesis. HIV triggers an immune response that involves numerous cellular and molecular processes related to
Vladimir S. Davydenko +5 more
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