Results 31 to 40 of about 49,192 (255)
Chemokine-induced secretion of gelatinase B in primary human monocytes [PDF]
, 2001 Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited ...
Brew K. +7 more
core +1 more source
Potential of CXCR4/CXCL12 Chemokine Axis in Cancer Drug Delivery [PDF]
Current Pharmacology Reports, 2016 This review discusses the potential of CXCR4 chemokine receptor in the design of anticancer and antimetastatic drug delivery systems. The role of CXCR4 in cancer progression and metastasis is discussed in the context of the development of several types of drug delivery strategies.
Yan, Wang, Ying, Xie, David, Oupický
openaire +2 more sources
Radiation-induced lung damage promotes breast cancer lung-metastasis through CXCR4 signaling [PDF]
, 2015 Radiotherapy is a mainstay in the postoperative treatment of breast cancer as it reduces the risks of local recurrence and mortality after both conservative surgery and mastectomy.
Bracke, Marc +8 more
core +6 more sources
The biological role of the CXCL12/CXCR4 axis in esophageal squamous cell carcinoma
Cancer Biology & Medicine, 2021 Esophageal cancer is the eighth most common malignant tumor and the sixth leading cause of cancer-related death worldwide. Esophageal squamous cell carcinoma (ESCC) is the main histological type of esophageal cancer, and accounts for 90% of all cancer ...
Xianxian Wu +4 more
doaj +1 more source
A guide to chemokines and their receptors [PDF]
, 2018 The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors.
Braun A +11 more
core +1 more source
MIF and CXCL12 in cardiovascular diseases: functional differences and similarities
Frontiers in Immunology, 2015 Coronary artery disease (CAD) as part of the cardiovascular diseases is a pathology caused by atherosclerosis, a chronic inflammatory disease of the vessel wall characterized by a massive invasion of lipids and inflammatory cells into the inner vessel ...
Emiel eVan Der Vorst +2 more
doaj +1 more source
CXCL12-PLGA/Pluronic Nanoparticle Internalization Abrogates CXCR4-Mediated Cell Migration
Nanomaterials, 2020 Chemokine-induced chemotaxis mediates physiological and pathological immune cell trafficking, as well as several processes involving cell migration. Among them, the role of CXCL12/CXCR4 signaling in cancer and metastasis is well known, and CXCR4 has been
Anissa Pisani +8 more
doaj +1 more source
Peptide-binding induced inhibition of chemokine CXCL12
RSC Advances, 2017 A designed peptide (W4) has a significant inhibitory effect on the CXCL12/CXCR4 axis by targeting CXCL12 with high binding affinity.
Hongyang Duan +13 more
openaire +2 more sources
The chemokine CXCL12 regulates monocyte-macrophage differentiation and RUNX3 expression [PDF]
Blood, 2011 Abstract Monocytes are versatile cells that can express different functional programs in response to microenvironmental signals. We show that primary blood monocytes secrete the CXCL12 chemokine, and express the CXCR4 and CXCR7 receptors, leading to an autocrine/paracrine loop that contribute to shape monocyte differentiation to a ...
Sánchez-Martín, Lorena +5 more
openaire +3 more sources
The diagnostic significance of the chemokine CXCL12 in Alzheimer's disease [PDF]
Alzheimer's & Dementia, 2021 AbstractBackgroundA complex relationship between the stromal cell‐derived factor 1 (CXCL12) and dementia, including mild cognitive impairment (MCI) and Alzheimer's disease (AD) has been described in the literature. The chemokine CXCL12 regulates many functions of bone marrow‐derived stem cells and has been implicated in neurogenesis as well as with the
Barbara Mroczko +5 more
openaire +1 more source