Results 1 to 10 of about 57,024 (115)

Rocuronium bromide suppresses esophageal cancer via blocking the secretion of C–X–C motif chemokine ligand 12 from cancer associated fibroblasts [PDF]

Journal of Translational Medicine, 2023
Background Cancer associated fibroblasts (CAFs) communicate metabolically with tumor genesis and development. Rocuronium bromide (RB) is reported to exert certain inhibitory effect on tumor.
Jingyi Li, Xuefeng Gu, Guoqing Wan, Yuhan Wang, Kaijie Chen, Qi Chen, Changlian Lu   +6 more
doaj   +2 more sources

C-X-C motif chemokine ligand 12—C-X-C chemokine receptor type 4 signaling axis in cancer and the development of chemotherapeutic molecules [PDF]

Tzu Chi Medical Journal
Chemokines are small, secreted cytokines crucial in the regulation of a variety of cell functions. The binding of chemokine C-X-C motif chemokine ligand 12 (CXCL12) (stromal cell-derived factor 1) to a G-protein-coupled receptor C-X-C chemokine receptor ...
Jui-Hung Yen, Chun-Chun Chang, Hao-Jen Hsu, Chin-Hao Yang, Hemalatha Mani, Je-Wen Liou   +5 more
doaj   +2 more sources

α1‐Adrenergic Receptors Function Within Hetero‐Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C‐X‐C motif) Receptor 4 in Vascular Smooth Muscle Cells

Journal of the American Heart Association, 2017
BackgroundRecently, we provided evidence that α1‐adrenergic receptors (ARs) in vascular smooth muscle are regulated by chemokine (C‐X‐C motif) receptor (CXCR) 4 and atypical chemokine receptor 3 (ACKR3). While we showed that CXCR4 controls α1‐ARs through
Jonathan Eby, Matthias Majetschak, Brian Volkman   +2 more
exaly   +3 more sources

Helper T cells and chemokines in elderly asthma – Mechanisms of airway inflammation and remodeling: A review [PDF]

Biomolecules & Biomedicine
Elderly bronchial asthma is a heterogeneous, often non-atopic disorder characterized by airway inflammation and remodeling influenced by age-related immune dysregulation. This review aims to elucidate the roles of helper T cells (Th cells) and chemokine
Youhua Wu
doaj   +2 more sources

Plasma interleukin-8 as a predictive biomarker for tyrosine kinase inhibitor response in advanced hepatocellular carcinoma [PDF]

Discover Oncology
Background and aim Hepatocellular carcinoma (HCC) is the predominant primary liver cancer and third leading cause of cancer-related death. Despite improvements in overall survival (OS), those in HCC-specific survival rates remain modest.
Sujin Kim, Hye Ri Ahn, Hui Gyeong Kim, Dooyeon Kim, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun, Hyo Jung Cho   +8 more
doaj   +2 more sources

CXCL12-CXCR4 axis: its role and the drug inhibitors on each type of cancers [PDF]

World Cancer Research Journal, 2022
Objective: Chemokine 12, C-X-C Motif Chemokine Ligand 12 (CXCL12), and its receptor C-X-C Motif Chemokine Ligand 4 (CXCR4), both play essential and critical roles in the development of different types of cancers.
A. Zarinkhat, C. Jalili, M. Pazhouhi, I. Rashidi, N. Akhshi, A. Ghanbari   +5 more
doaj   +1 more source

Chemokines in ICU Delirium: An Exploratory Study

Critical Care Explorations, 2022
OBJECTIVES:. The pathophysiology of delirium is complex and incompletely understood. Inflammation is hypothesized to be integral to its development due to effects on blood brain barrier integrity, facilitation of leukocyte extravasation into brain ...
Ryan J. Smith, MD, JD, Alejandro A. Rabinstein, MD, Rodrigo Cartin-Ceba, MD, MSc, Vijay P. Singh, MBBS, MD, Christian Lachner, MD, Biswajit Khatua, PhD, Shubham Trivedi, BS, Ognjen Gajic, MD   +7 more
doaj   +1 more source

Evidence for Monocyte Reprogramming in a Long-Term Postsepsis Study

Critical Care Explorations, 2022
OBJECTIVES:. This study sought to identify monocyte alterations from septic patients after hospital discharge by evaluating gene expression of inflammatory mediators and monocyte polarization markers.
Raquel Bragante Gritte, PhD, Talita Souza-Siqueira, PhD, Eliane Borges da Silva, PhD, Laiane Cristina dos Santos de Oliveira, PhD, Rodrigo Cerqueira Borges, PhD, Heloísa H de Oliveira Alves, PhD, Laureane Nunes Masi, PhD, Gilson Masahiro Murata, PhD, Renata Gorjão, PhD, Adriana Cristina Levada-Pires, PhD, Antônio Carlos Nogueira, PhD, Tânia Cristina Pithon-Curi, PhD, Ricardo Bentes de Azevedo, PhD, Francisco Garcia Soriano, MD, PhD, Rui Curi, PhD, Marcel Cerqueira Cesar Machado, MD, PhD   +15 more
doaj   +1 more source

Immunological effects of anti-coagulant unfractionated heparin in pregnant Chinese women with cryptic recurrent miscarriages

Archives of Medical Science, 2020
Introduction Anti-coagulant unfractionated heparin of low molecular weight (ACUHlmw) therapy is popularly practised in the therapy of recurrent miscarriages (RMC) due to its anti-coagulant properties.
Yanli Hong, Ke Hong, Xiaojuan Chen, Jinting Xue, Yanyun Yin   +4 more
doaj   +1 more source

Temporal characteristics of astrocytic activation in the TNC in a mice model of pain induced by recurrent dural infusion of inflammatory soup

The Journal of Headache and Pain, 2022
Background Astrocytic activation might play a significant role in the central sensitization of chronic migraine (CM). However, the temporal characteristics of the astrocytic activation in the trigeminal nucleus caudalis (TNC) and the molecular mechanism ...
Leyi Zhang, Chenglong Lu, Li Kang, Yingji Li, Wenjing Tang, Dengfa Zhao, Shengyuan Yu, Ruozhuo Liu   +7 more
doaj   +1 more source