Results 1 to 10 of about 54,876 (141)

The immunoregulatory axis (programmed death‐1/programmed death ligand‐1) on CD4+ T cells in lupus nephritis: association with vitamin D and chemokine C‐X‐C motif ligand 12

Microbiology and Immunology, 2021
AbstractLupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE). Multiple immunomodulatory mechanisms contribute to the pathogenesis of LN. A deep understanding of the immunopathogenesis of LN is essential to identify optimal molecular targets, as most immunotherapeutic algorithms are still based on ...
Sara Youssry, Amina Hussein, Mai Moaaz
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Chemokine (C-X-C Motif) Ligand 12/Stromal Cell-Derived Factor-1 Is Associated With Leukocyte Recruitment in Asthma

Chest, 2010
Asthma is characterized by allergic airway inflammatory response involving extensive leukocyte infiltration. The stromal cell-derived factor (SDF)-1 or chemokine (C-X-C motif) ligand 12 (CXCL12) attracts a number of cells, including resting T lymphocytes, monocytes, CD34(+) stem cells, basophils, and mature eosinophils.
María Cristina, Negrete-García, Juan R, Velazquez, Antonio, Popoca-Coyotl, A Rosalía, Montes-Vizuet, Esmeralda, Juárez-Carvajal, Luis Manuel, Teran   +5 more
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Chemokine (C-X-C Motif) Ligand 12 Is Associated with Gallbladder Carcinoma Progression and Is a Novel Independent Poor Prognostic Factor

Clinical Cancer Research, 2012
Abstract Purpose: Although recent studies have suggested that chemokine (C-X-C motif) ligand 12 (CXCL12) is important in the progression of various malignancies, its role in gallbladder carcinoma (GBC) remains unknown. We investigated CXCL12 expression in GBC and its biologic and prognostic role in GBC tumorigenesis.
Hyun Jung, Lee, Kyungmin, Lee, Dong Gwang, Lee, Kwang-Hee, Bae, Jang-Seong, Kim, Zhe Long, Liang, Song Mei, Huang, Yoon, Suk Oh, Ha Yon, Kim, Deog Yeon, Jo, Jeong-Ki, Min, Jin-Man, Kim, Hyo Jin, Lee   +12 more
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Local Blockade of Interleukin 10 and C-X-C Motif Chemokine Ligand 12 with Nano-Delivery Promotes Antitumor Response in Murine Cancers

ACS Nano, 2018
In many cancers, the tumor microenvironment (TME) is largely immune suppressive, blocking the antitumor immunity and resulting in immunotherapy resistance. Interleukin 10 (IL-10) is a major player controlling the immunosuppressive TME in different murine tumor models.
Li, Jingjing, Tiruthani, Karthik, Liu, Rihe, Liu, Qi, Huang, Leaf, Goodwin, Tyler Jay, Das, Manisit, Song, Wantong, Shen, Limei, Zhang, Xueqiong, Hu, Haiyang   +10 more
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Novel circularRNA circ-0047078 promotes pancreatic ductal adenocarcinoma progression through mircoRNA miR-11181— Chemokine (C-X-C motif) Ligand 12/Melanoma Cell Adhesion Molecule/Regulator of G-protein signaling 16 pathway

Molecular Biology Reports, 2022
Circular RNAs (circRNAs), new members of the noncoding RNA family, have been reported to participate in various pathological conditions, especially cancer. Pancreatic ductal adenocarcinoma (PDAC), as one of the most aggressive human solid tumors, is still with a low surgical cure rate. Exploring the role of circRNAs in PDAC is meaningful, and may offer
Yuzhou Wang, Hangwei Fu, Yan Jiang, Bo Zhou, Ping Chen   +4 more
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[Research progress of C-X-C motif chemokine ligand 12 and its receptor signaling axis in the regulation of pulmonary fibrosis].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2022
Pulmonary fibrosis is an irreversible interstitial lung disease characterized by lung parenchyma remodeling and collagen deposition. In recent years, the incidence and mortality of pulmonary fibrosis caused by unknown causes have risen. However, its pathogenesis is still unclear.
Q X, Sun, M, Mu, X R, Tao
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Relationship between chemokine (C–X–C motif) ligand 12 gene variant (rs1746048) and coronary heart disease: Case–control study and meta-analysis

Gene, 2013
The goal of our study is to evaluate the contribution of CXCL12 rs1746048 (hg19, chr10:44775574) to the risk of CHD in Han Chinese, and to summarize its role in CHD through meta-analysis of existing studies among various ethnic groups. Significant association is observed between rs1746048-C and an increased risk of CHD in Han Chinese (χ(2)=5.41, df=1 ...
Yi, Huang, Jianqing, Zhou, Huadan, Ye, Limin, Xu, Yanping, Le, Xi, Yang, Weifeng, Xu, Xiaoyan, Huang, Jiangfang, Lian, Shiwei, Duan   +9 more
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[C-X-C motif chemokine ligand 12/C-X-C motif chemokine receptor 4 regulates oxygen glucose deprivation/reoxygenation-induced autophagy in SH-SY5Y neuronal cells].

Zhonghua wei zhong bing ji jiu yi xue
To explore the effects and mechanisms of the C-X-C motif chemokine ligand 12/C-X-C motif chemokine receptor 4 (CXCL12/CXCR4) signaling axis on apoptosis and autophagy in SH-SY5Y neuronal cells subjected to oxygen-glucose deprivation/reperfusion (OGD/R) model in vitro.SH-SY5Y cells were divided into the following groups: OGD/R group and non-OGD/R group,
Haining, Meng, Chao, Jia, Qingshu, Li, Weifeng, Xie, Sumei, Wang, Yan, Qu   +5 more
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Molecular characterization and chemotaxis assay of a CC motif chemokine ligand 25 from Japanese sea bass (Lateolabrax japonicus)

Fish and Shellfish Immunology, 2021
Lingling Zhang, Chang-Hong Li, Jiong Chen   +2 more
exaly  

On the Role of Paraoxonase-1 and Chemokine Ligand 2 (C-C motif) in Metabolic Alterations Linked to Inflammation and Disease. A 2021 Update

Biomolecules, 2021
Jordi Camps, Helena Castane, Elisabet Rodríguez-Tomàs   +2 more
exaly