Evaluation of the influence of the C-X-C motif chemokine ligand 12 / C-X-C chemokine receptor 4 axis on canine mammary gland tumor cell migration. [PDF]
J Vet Med Sci, 2023 C-X-C motif chemokine ligand 12 (CXCL12) is one of the chemokines that binds to C-X-C chemokine receptor 4 (CXCR4) on tumor cell membranes and induces chemotaxis and/or migration.
Kudo A +6 more
europepmc +5 more sources
MEK1/2 inhibitor inhibits neointima formation by activating miR-126-3p/ C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 4 (CXCR4) axis. [PDF]
Bioengineered, 2022 Endothelial dysfunction is an initial and essential step in vascular-remodeling diseases, including atherosclerosis and neointima formation. During vascular remodeling, activated endothelial cells can release pro-inflammatory factors that promote ...
Yan Y +10 more
europepmc +4 more sources
MicroRNA-200b-3p restrains gastric cancer cell proliferation, migration, and invasion via C-X-C motif chemokine ligand 12/CXC chemokine receptor 7 axis. [PDF]
Bioengineered, 2022 This study was conducted to investigate the impact of microRNA (miR)-200b-3p on viability, migration, and invasion of gastric cancer (GC) cells and its mechanism.
Li D, Li Q.
europepmc +4 more sources
Differential expression of C-X-C motif chemokine ligand 12, CXCL12, in cancers of the breast.
, 2021 Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast ...
Shahan Mamoor
core +3 more sources
Indian Journal of Pathology and Microbiology, 2020 Background: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer worldwide. It is essential to develop methods for the accurate diagnosis of PTC to avoid unnecessary surgery.
Sang Ah Lee +4 more
doaj +3 more sources
Stromal cell-derived factor-1 (chemokine C-X-C motif ligand 12) and chemokine C-X-C motif receptor 4 are required for migration of gonadotropin-releasing hormone neurons to the forebrain [PDF]
Journal of Neuroscience, 2011 Gonadotropin-releasing hormone (GnRH) neurons migrate from the vomeronasal organ (VNO) in the nasal compartment to the basal forebrain in mice, beginning on embryonic day 11 (E11).
Nugent, J. David +4 more
core +5 more sources
Chinese Journal of Cancer, 2017 Background Recent studies indicate that C-X-C motif chemokine receptor 4 (CXCR4) and its ligand, C-X-C motif chemokine ligand 12 (CXCL12), stimulate expression of the cell cycle regulatory protein Cyclin D1 in neurofibromatosis 1-associated malignant ...
Chao Zhang +3 more
doaj +2 more sources
Collagen content and C-X-C motif chemokine ligand 12 expression in neoplastic breast stroma. [PDF]
Rev Assoc Med Bras (1992), 2023 This study aimed to evaluate the expression of C-X-C motif chemokine ligand 12 and its C-X-C chemokine receptor type 4, and the tumor-stroma ratio using collagen stromal content of breast cancer samples, correlating it with clinicopathological data.Through a retrospective cohort study, samples were obtained from female patients, over 18 years of age ...
Ferreira CJDS +3 more
europepmc +4 more sources
C-X-C motif chemokine ligand 12: a potential therapeutic target in Duchenne muscular dystrophy. [PDF]
Bioengineered, 2021 Duchenne muscular dystrophy (DMD) is an X-linked recessive disease caused by a mutant dystrophin protein. DMD patients undergo gradual progressive paralysis until death. Chronic glucocorticoid therapy remains one of the main treatments for DMD, despite the significant side effects. However, its mechanisms of action remain largely unknown.
Lai X, Chen J.
europepmc +4 more sources
C‑X‑C receptor 7 agonist acts as a C‑X‑C motif chemokine ligand 12 inhibitor to ameliorate osteoclastogenesis and bone resorption. [PDF]
Mol Med Rep, 2022 The C‑X‑C receptor (CXCR) 7 agonist, VUF11207, is a chemical compound that binds specifically to CXCR7, and negatively regulates C‑X‑C motif chemokine ligand 12 (CXCL12) and CXCR4‑induced cellular events. Lipopolysaccharide (LPS) can induce inflammatory cytokines and pathological bone loss.
Nugraha AP +9 more
europepmc +4 more sources