MEK1/2 inhibitor inhibits neointima formation by activating miR-126-3p/ C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 4 (CXCR4) axis [PDF]
Bioengineered, 2022 Endothelial dysfunction is an initial and essential step in vascular-remodeling diseases, including atherosclerosis and neointima formation. During vascular remodeling, activated endothelial cells can release pro-inflammatory factors that promote phenotypic switching of vascular smooth muscle cells (VSMCs) to the proliferative phenotype.
Yali Yan +10 more
openaire +3 more sources
C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 7(CXCR7) regulates epithelial-mesenchymal transition process and promotes the metastasis of esophageal cancer by activating signal transducer and activator of transcription 3 (STAT3) pathway [PDF]
Bioengineered, 2022 Esophageal cancer is a malignant tumor of the digestive system that is prone to metastasis. Chemokines and their receptors act an essential role in the occurrence and development of tumors. Here, we investigated the regulatory mechanism of CXCL12/CXCR7 in the growth and metastasis of esophageal cancer.
Jing Guo +3 more
openaire +3 more sources
Helper T cells and chemokines in elderly asthma – Mechanisms of airway inflammation and remodeling: A review [PDF]
Biomolecules & BiomedicineElderly bronchial asthma is a heterogeneous, often non-atopic disorder characterized by airway inflammation and remodeling influenced by age-related immune dysregulation. This review aims to elucidate the roles of helper T cells (Th cells) and chemokine
Youhua Wu
doaj +2 more sources
Substrate stiffness modulates human gingival fibroblast paracrine signaling to promote osteogenic differentiation of human periodontal ligament cells [PDF]
Frontiers in Bioengineering and BiotechnologyBackgroundHuman gingival fibroblasts (HGFs) are stromal cells that maintain periodontal tissue structure and extracellular matrix (ECM) dynamics. ECM stiffness serves as a physical cue that regulates HGF behavior and secretory profiles.
Watcharaphol Tiskratok +12 more
doaj +2 more sources
CXCL12-CXCR4 axis: its role and the drug inhibitors on each type of cancers [PDF]
World Cancer Research Journal, 2022 Objective: Chemokine 12, C-X-C Motif Chemokine Ligand 12 (CXCL12), and its receptor C-X-C Motif Chemokine Ligand 4 (CXCR4), both play essential and critical roles in the development of different types of cancers.
A. Zarinkhat +5 more
doaj +1 more source
CXCL12 (chemokine (C-X-C motif) ligand 12) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2017 Review on CXCL12, with data on DNA, on the protein encoded, and where the gene is implicated.
Giulia Gentile +2 more
openaire +4 more sources
The biological role of the CXCL12/CXCR4 axis in esophageal squamous cell carcinoma
Cancer Biology & Medicine, 2021 Esophageal cancer is the eighth most common malignant tumor and the sixth leading cause of cancer-related death worldwide. Esophageal squamous cell carcinoma (ESCC) is the main histological type of esophageal cancer, and accounts for 90% of all cancer ...
Xianxian Wu +4 more
doaj +1 more source
The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer
Frontiers in Pharmacology, 2020 Chemokines are a family of small, secreted cytokines which regulate a variety of cell functions. The C-X-C motif chemokine ligand 12 (CXCL12) binds to C-X-C chemokine receptor type 4 (CXCR4) and C-X-C chemokine receptor type 7 (CXCR7). The interaction of
Yi Shi, David J. Riese, Jianzhong Shen
doaj +1 more source
Frontiers in Genetics, 2021 The burden of hepatocellular carcinoma (HCC) worldwide is increasing over time, while the underlying molecular mechanism of HCC development is still under exploration.
Yuwei Gu +11 more
doaj +1 more source
The N-terminus of CXCR4 splice variants determines expression and functional properties.
PLoS ONE, 2023 C-X-C motif chemokine ligand 12(CXCL12) is an essential chemokine for organ development and homeostasis in multiple tissues. Its receptor, C-X-C chemokine receptor type 4(CXCR4), is expressed on the surface of target cells. The chemokine and receptor are
Hee-Kyung Park +10 more
doaj +1 more source