Results 21 to 30 of about 28,666,794 (72)

CXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain [PDF]

, 2016
The roles of chemokine C-X-C motif ligand 12 (CXCL12) and its receptor chemokine C-X-C motif receptor 4 (CXCR4) reveal this chemokine axis as an emerging neuromodulator in the nervous system. In the peripheral and central nervous systems, both CXCL12 and
Chung, SK, Wang, XMA, Xia, Z, Luo, X, Cheung, CW   +4 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Ligand-Based NMR Study of C‑X‑C Chemokine Receptor Type 4 (CXCR4)–Ligand Interactions on Living Cancer Cells

, 2018
Peptide-binding G protein-coupled receptors (GPCRs) are key effectors in numerous pathological and physiological pathways. The assessment of the receptor-bound conformation of a peptidic ligand within a membrane receptor such as a GPCR is of great impact
Marinelli, Luciana, Salvatore Di Maro, Luigi Portella (458550), Stefania Scala, Luigi Russo, Stefania Scala (458561), Scala, Stefania, Di Maro, Salvatore, Luigi Portella, Francesco Saverio Di Leva, Anna Maria Trotta, Stefano Tomassi (1533535), Diego Brancaccio (1451125), Donatella Diana (2224633), Alfonso Carotenuto (405657), Trotta, Anna Maria, Stefano Tomassi, Ettore Novellino, Fattorusso, Roberto, Luciana Marinelli, Russo, Luigi, Luigi Russo (73534), Anna Maria Trotta (3110427), Brancaccio, Diego, Salvatore Di Maro (405660), Roberto Fattorusso (1616809), Roberto Fattorusso, Luciana Marinelli (1264995), Alfonso Carotenuto, Tomassi, Stefano, Donatella Diana, Francesco Saverio Di Leva (1745107), Carotenuto, Alfonso, Diego Brancaccio, Ettore Novellino (333902), Diana, Donatella, Di Leva, Francesco Saverio, Portella, Luigi, Novellino, Ettore   +38 more
core   +1 more source

Presentation_1_Inhibition of the C-X-C Motif Chemokine 12 (CXCL12) and Its Receptor CXCR4 Reduces Utero-Placental Expression of the VEGF System and Increases Utero-Placental Autophagy.ZIP

, 2021
The placenta, a unique organ that only develops during pregnancy, is essential for nutrient, oxygen, and waste exchange between offspring and mother. Yet, despite its importance, the placenta remains one of the least understood organs and knowledge of ...
Ryan L. Ashley (11276376), Elisa Trigo (11276385), Cheyenne L. Runyan (11276379), Marlie M. Maestas (11276382), Gail Silver (11276388)   +4 more
core   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Chemokine (C-X-C motif) ligand (CXCL)10 in autoimmune diseases.

, 2014
(C-X-C motif) ligand (CXCL)10 (CXCL10) belongs to the ELR(-) CXC subfamily chemokine. CXCL10 exerts its function through binding to chemokine (C-X-C motif) receptor 3 (CXCR3), a seven trans-membrane receptor coupled to G proteins. CXCL10 and its receptor,
Ferri C, Fallahi P., Ele Ferrannini, Ferrannini E, Alessandro Antonelli, Giuggioli D, FERRI, Clodoveo, Silvia Martina Ferrari, Clodoveo Ferri, Antonelli A, ANTONELLI, ALESSANDRO, FERRANNINI, ELEUTERIO, Poupak Fallahi, Ferrari SM, Dilia Giuggioli, FERRARI, Silvia Martina   +15 more
core   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

The prognostic value of C-X-C motif chemokine receptor 4 in patients with sporadic malignant peripheral nerve sheath tumors

, 2017
Background Recent studies indicate that C-X-C motif chemokine receptor 4 (CXCR4) and its ligand, C-X-C motif chemokine ligand 12 (CXCL12), stimulate expression of the cell cycle regulatory protein Cyclin D1 in neurofibromatosis 1-associated malignant ...
Wen-Ya Zhou, Chao Zhang, Ji-Long Yang, Fang-Yuan Chang   +3 more
core   +1 more source

Four‐dimensional immuno‐mechanobiomaterials: Dynamic material cues that program host response to prevent fibrosis and enable regeneration

VIEW, EarlyView.
Dynamic immuno‐mechanobiomaterials with time‐programmed mechanical adaptation orchestrate host responses through precise mechanotransduction and immune‐stromal regulation. These adaptive biomaterials minimize mechanical mismatch, attenuate the forign dy response and fibrosis, promote angiogenesis and controlled extracellular matrix remodeling, and ...
Gobinath Vellapalayam Manoharan, Kathirvel Ayyaswamy, Parthasarathy Vellaichamy, Nagarajan Deivanayagam Pillai, Rithik Gobinath   +4 more
wiley   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source