Results 11 to 20 of about 153 (107)

The prognostic value of C-X-C motif chemokine receptor 4 in patients with sporadic malignant peripheral nerve sheath tumors

Chinese Journal of Cancer, 2017
Background Recent studies indicate that C-X-C motif chemokine receptor 4 (CXCR4) and its ligand, C-X-C motif chemokine ligand 12 (CXCL12), stimulate expression of the cell cycle regulatory protein Cyclin D1 in neurofibromatosis 1-associated malignant ...
Chao Zhang, Fang-Yuan Chang, Wen-Ya Zhou, Ji-Long Yang   +3 more
doaj   +1 more source

New Insights on the Emerging Genomic Landscape of CXCR4 in Cancer: A Lesson from WHIM

Vaccines, 2020
Deciphering the molecular alterations leading to disease initiation and progression is currently crucial to identify the most relevant targets for precision therapy in cancer patients.
Stefania Scala, Crescenzo D’Alterio, Samantha Milanesi, Alessandra Castagna, Roberta Carriero, Floriana Maria Farina, Massimo Locati, Elena Monica Borroni   +7 more
doaj   +1 more source

Single-cell transcriptomic analysis reveals differential cell subpopulations and distinct phenotype transition in normal and dissected ascending aorta

Molecular Medicine, 2022
Background Acute thoracic aortic dissection (ATAD) is a fatal condition characterized by tear of intima, formation of false lumen and rupture of aorta. However, the subpopulations of normal and dissected aorta remain less studied. Methods Single-cell RNA
Yu-bin He, Hai-zhen Jin, Jin-long Zhao, Chong Wang, Wen-rui Ma, Jie Xing, Xiao-bin Zhang, Yang-yang Zhang, Huang-dong Dai, Nai-shi Zhao, Jian-feng Zhang, Guan-xin Zhang, Jing Zhang   +12 more
doaj   +1 more source

xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity

Cell Reports, 2023
Summary: Obesity-mediated hypoxic stress underlies inflammation, including interferon (IFN)-γ production by natural killer (NK) cells in white adipose tissue. However, the effects of obesity on NK cell IFN-γ production remain obscure.
Hee-Hoon Kim, Young-Ri Shim, Ha Neul Kim, Keungmo Yang, Tom Ryu, Kyurae Kim, Sung Eun Choi, Min Jeong Kim, Chaerin Woo, Katherine Po Sin Chung, Song Hwa Hong, Hyemi Shin, Jae Myoung Suh, Youngae Jung, Geum-Sook Hwang, Won Kim, Seok-Hwan Kim, Hyuk Soo Eun, Je Kyung Seong, Won-Il Jeong   +19 more
doaj   +1 more source

The Chemokine Receptor CXCR4 and c-MET Cooperatively Promote Epithelial-Mesenchymal Transition in Gastric Cancer Cells

Translational Oncology, 2018
The C-X-C motif chemokine receptor 4 (CXCR4) pathway can promote tumor metastasis but is dependent on cross talk with other signaling pathways. The MET proto-oncogene (c-MET) participates in metastasis and is highly expressed in gastric cancer.
Yu Cheng, Yongxi Song, Jinglei Qu, Xiaofang Che, Na Song, Yibo Fan, Ti Wen, Ling Xu, Jing Gong, Xiaoxun Wang, Chenlu Zhang, Xiujuan Qu, Yunpeng Liu   +12 more
doaj   +1 more source

Differential expression of C-X-C motif chemokine ligand 12, CXCL12, in cancers of the breast.

, 2021
Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding C-X-C motif chemokine
openaire   +2 more sources

Nucleophosmin 1 associating with engulfment and cell motility protein 1 regulates hepatocellular carcinoma cell chemotaxis and metastasis

Open Medicine, 2023
The chemokine, C-X-C motif chemokine ligand 12 (CXCL12) and its G-protein-coupled receptor (GPCR) and C-X-C chemokine receptor type 4 (CXCR4), are closely associated with promoting hepatocellular carcinoma (HCC) chemotaxis and metastasis.
Yang Gangqi, Li Hongyan, Dong Zheng, Deng Kai, Lu Yinying   +4 more
doaj   +1 more source

Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer

Advanced Science, 2021
Cellular senescence can either support or inhibit cancer progression. Here, it is shown that intratumoral infiltration of CD8+ T cells is negatively associated with the proportion of senescent tumor cells in colorectal cancer (CRC).
Yong Won Choi, Young Hwa Kim, Seung Yeop Oh, Kwang Wook Suh, Young‐Sam Kim, Ga‐Yeon Lee, Jung Eun Yoon, Soon Sang Park, Young‐Kyoung Lee, Yoo Jung Park, Hong Seok Kim, So Hyun Park, Jang‐Hee Kim, Tae Jun Park   +13 more
doaj   +1 more source

What is the response profile of deciduous pulp fibroblasts stimulated with E. coli LPS and E. faecalis LTA?

BMC Immunology, 2020
Background Oral fibroblast immunological responses to bacterial stimuli are well known. However, there are few studies about pulp fibroblasts from deciduous teeth (HDPF) responses, which are important for the treatment of pulp infections in children. The
Bella Luna Colombini-Ishikiriama, Thiago Jose Dionisio, Thais Francini Garbieri, Rafaela Alves da Silva, Maria Aparecida Andrade Moreira Machado, Sandra Helena Penha de Oliveira, Vanessa Soares Lara, Andrew Seth Greene, Carlos Ferreira Santos   +8 more
doaj   +1 more source

miR-135a-5p alleviates morphine tolerance by targeting the regulation of CXCL12 expression [PDF]

Jichu yixue yu linchuang
Objective Investigating the effect of miR-135a-5p in regulating of CXCL12 on the formation of morphine tolerance in C57BL/6J mice. Methods Totally 64 mice were randomly divided into the following groups: control (NS) group, morphine tolerance (MT ...
HE Huamei, LU Wei
doaj   +1 more source