MicroRNA‑31 promotes chondrocyte proliferation by targeting C‑X‑C motif chemokine ligand 12. [PDF]
Mol Med Rep, 2019 The present study aimed to investigate the biological function and underlying molecular mechanisms of miR-31 in osteoarthritis (OA). Reverse transcription‑quantitative polymerase chain reaction was used to detect miR‑31 expression, and it was found that miR‑31 was downregulated in the cartilage tissues of OA patients.
Dai Y +5 more
europepmc +4 more sources
C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 7(CXCR7) regulates epithelial-mesenchymal transition process and promotes the metastasis of esophageal cancer by activating signal transducer and activator of transcription 3 (STAT3) pathway. [PDF]
Bioengineered, 2022 Esophageal cancer is a malignant tumor of the digestive system that is prone to metastasis. Chemokines and their receptors act an essential role in the occurrence and development of tumors. Here, we investigated the regulatory mechanism of CXCL12/CXCR7 in the growth and metastasis of esophageal cancer.
Guo J, Tong CY, Shi JG, Li XJ.
europepmc +3 more sources
Increased C-X-C Motif Chemokine Ligand 12 Levels in Cerebrospinal Fluid as a Candidate Biomarker in Sporadic Amyotrophic Lateral Sclerosis. [PDF]
Int J Mol Sci, 2020 Sporadic amyotrophic lateral sclerosis (sALS) is a fatal progressive neurodegenerative disease affecting upper and lower motor neurons. Biomarkers are useful to facilitate the diagnosis and/or prognosis of patients and to reveal possible mechanistic clues about the disease.
Andrés-Benito P +13 more
europepmc +10 more sources
Local tissue response to a C-X-C motif chemokine ligand 12 therapy for fecal incontinence in a rabbit model. [PDF]
Am J Physiol Gastrointest Liver PhysiolLocal injection of CXCL12 cytokine reduces postinjury fibrosis in a rabbit model of anal sphincter injury and fecal incontinence. The larger size of the rabbits aided in targeted injury and treatment. Further studies are needed to explore noninvasive treatment options for postparturient anal sphincter injury.
Ruetten HM +5 more
europepmc +4 more sources
The Effect of C-X-C Motif Chemokine Ligand 12 in Colorectal Cancer Associated with Chemoresistance and Radioresistance as Well as Stemness. [PDF]
Iran J Public HealthBackground: We aimed to explore the role of C-X-C motif chemokine ligand 12 (CXCL12) and cytokine-cytokine receptor interaction signaling pathway in the radiotherapy and chemotherapy resistance as well as cell stemness in colorectal cancer (CRC). Methods: Bioinformatics analysis was used to identify the differentially expressed mRNAs and signal ...
Dong W, Lin W, Li C.
europepmc +3 more sources
CXCL12-CXCR4 axis: its role and the drug inhibitors on each type of cancers [PDF]
World Cancer Research Journal, 2022 Objective: Chemokine 12, C-X-C Motif Chemokine Ligand 12 (CXCL12), and its receptor C-X-C Motif Chemokine Ligand 4 (CXCR4), both play essential and critical roles in the development of different types of cancers.
A. Zarinkhat +5 more
doaj +1 more source
Chemokines in ICU Delirium: An Exploratory Study
Critical Care Explorations, 2022 OBJECTIVES:. The pathophysiology of delirium is complex and incompletely understood. Inflammation is hypothesized to be integral to its development due to effects on blood brain barrier integrity, facilitation of leukocyte extravasation into brain ...
Ryan J. Smith, MD, JD +7 more
doaj +1 more source
Interleukin-17A Promotes Airway Remodeling in Chronic Obstructive Pulmonary Disease by Activating C-X-C Motif Chemokine Ligand 12 Secreted by Lung Fibroblasts. [PDF]
Chronic Obstr Pulm DisThe interactions between fibroblasts and bronchial epithelial cells play important roles in the development of chronic obstructive pulmonary disease (COPD). Interleukin (IL)-17A triggers the activation of fibroblasts and the secretion of inflammatory mediators, which promotes epithelial-mesenchymal transition (EMT) in bronchial epithelial cells ...
Chen X +6 more
europepmc +3 more sources
Potential of C‐X‐C motif chemokine ligand 1/8/10/12 as diagnostic and prognostic biomarkers in idiopathic pulmonary arterial hypertension [PDF]
The Clinical Respiratory Journal, 2021 AbstractObjectiveThis study aimed to evaluate the clinical role of C‐X‐C motif chemokine ligand (CXCL) family members in idiopathic pulmonary arterial hypertension (IPAH) patients.MethodsCXCL1, CXCL8, CXCL10 and CXCL12 expressions in the serum samples of IPAH patients (N = 39) and age‐/gender‐matched controls (N = 40) were detected by enzyme‐linked ...
Zhenhua Li, Jie Jiang, Shan Gao
openaire +2 more sources