Niacin downregulates chemokine (c-c motif) ligand 2 (CCL2) expression and inhibits fat synthesis in rat liver cells [PDF]
, 2020 Purpose: To elucidate the role of chemokine (c-c motif) ligand 2 (CCL2) in fat metabolism in hepatocytes. Methods: Following partial hepatectomy, regenerated rat liver cells were isolated and cultured for 24 h were transfected with recombinant plasmid ...
Xing, Xuekun +6 more
core +2 more sources
CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes [PDF]
, 2014 Standard culture of human induced pluripotent stem cells (hiPSCs) requires basic Fibroblast Growth Factor (bFGF) to maintain the pluripotent state, whereas hiPSC more closely resemble epiblast stem cells than true naïve state ES which requires LIF to ...
Tang, D +39 more
core +1 more source
C-X-C Motif Chemokine Receptor 4 Blockade Promotes Tissue Repair After Myocardial Infarction by Enhancing Regulatory T Cell Mobilization and Immune-Regulatory Function. [PDF]
, 2019 Acute myocardial infarction (MI) elicits an inflammatory response that drives tissue repair and adverse cardiac remodeling. Inflammatory cell trafficking after MI is controlled by C X-C motif chemokine ligand 12 (CXCL12) and its receptor, C-X-C motif ...
Wollert, Kai C +30 more
core +1 more source
Protein-protein interaction network of identified biomarkers. [PDF]
, 2022 CCL23, chemokine (C-C motif) ligand 23; CXCL12, chemokine (C-X-C motif) ligand 12; IGFBP6, insulin-like growth factor binding protein 6; IL5, interleukin 5; LYVE1, lymphatic vessel endothelial hyaluronan receptor 1; SERPINE1, plasminogen activator ...
Hui-Sheng Chen (6691241) +6 more
core +1 more source
Impact of isolation procedures on the development of a preclinical synovial fibroblasts/macrophages in an in vitro model of osteoarthritis [PDF]
, 2020 There is a lack of in vitro models able to properly represent osteoarthritis (OA) synovial tissue (ST). We aimed to characterize OA ST and to investigate whether a mechanical or enzymatic digestion procedures influence synovial cell functional ...
Manferdini C. +6 more
core +1 more source
IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs. [PDF]
, 2015 The series of events leading to tertiary lymphoid organ (TLO) formation in mucosal organs following tissue damage remain unclear. Using a virus-induced model of autoantibody formation in the salivary glands of adult mice, we demonstrate that IL-22 ...
Barone, F. +17 more
core +4 more sources
NLRP12 Inflammasome Expression in the Rat Brain in Response to LPS during Morphine Tolerance
Brain Sciences, 2017 Morphine, an effective but addictive analgesic, can profoundly affect the inflammatory response to pathogens, and long-term use can result in morphine tolerance. Inflammasomes are protein complexes involved in the inflammatory response.
Sulie L. Chang +3 more
doaj +1 more source
miR-135a-5p alleviates morphine tolerance by targeting the regulation of CXCL12 expression [PDF]
Jichu yixue yu linchuangObjective Investigating the effect of miR-135a-5p in regulating of CXCL12 on the formation of morphine tolerance in C57BL/6J mice. Methods Totally 64 mice were randomly divided into the following groups: control (NS) group, morphine tolerance (MT ...
HE Huamei, LU Wei
doaj +1 more source
External validation of urinary C-C motif chemokine ligand 14 (CCL14) for prediction of persistent acute kidney injury. [PDF]
, 2021 Persistent acute kidney injury (AKI) portends worse clinical outcomes and remains a therapeutic challenge for clinicians. A recent study found that urinary C-C motif chemokine ligand 14 (CCL14) can predict the development of persistent AKI.
Artigas, Antonio +17 more
core +1 more source
Roles of Major Chemokines in the Pathophysiology of Atrial Fibrillation
Cardiovascular Innovations and ApplicationsChemokines are a subclass of cytokines, a large family of small secreted proteins that communicate via G protein-coupled heptahelical chemokine receptors on the cell surface.
Saira Rafaqat +4 more
doaj +1 more source