Results 61 to 70 of about 55,700 (269)

Data from Chemokine (C-X-C Motif) Ligand 12 Is Associated with Gallbladder Carcinoma Progression and Is a Novel Independent Poor Prognostic Factor

, 2023
<div>Abstract<p><b>Purpose:</b> Although recent studies have suggested that chemokine (C-X-C motif) ligand 12 (CXCL12) is important in the progression of various malignancies, its role in gallbladder carcinoma (GBC) remains unknown.
Hyo Jin Lee, Jin-Man Kim, Jeong-Ki Min, Deog Yeon Jo, Ha Yon Kim, Yoon Suk Oh, Song Mei Huang, Zhe Long Liang, Jang-Seong Kim, Kwang-Hee Bae, Dong Gwang Lee, Kyungmin Lee, Hyun Jung Lee   +12 more
openaire   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Putative Transcriptomic Biomarkers in the Inflammatory Cytokine Pathway Differentiate Major Depressive Disorder Patients from Control Subjects and Bipolar Disorder Patients [PDF]

, 2014
Mood disorders consist of two etiologically related, but distinctly treated illnesses, major depressive disorder (MDD) and bipolar disorder (BPD). These disorders share similarities in their clinical presentation, and thus show high rates of misdiagnosis.
Farmer, A., Farmer, Anne E, Powell, Timothy R, Matthews Keith, Day, Richard K, Anne E. Farmer (215007), Powell Timothy R., Farmer, Anne E., Hosang Georgina M., Farmer Anne E., Martin, C, Leonard C. Schalkwyk (27674), Day, Richard K., Cohen-Woods Sarah, Katherine E. Tansey (128003), Cohen-Woods, Sarah, Richard K Day, Timothy R. Powell (533562), McGuffin Peter, Day Richard K., Farmer, AE, Matthews, K, Hosang, GM, Schalkwyk, Leonard, Schalkwyk, L., Timothy R Powell, Keith Matthews (22202), Tansey, Katherine E., Powell, TR, Matthews, K., Tansey, Katherine E, Powell, Timothy; id_orcid, Georgina M Hosang, Sarah Cohen-Woods (214940), Tansey, K., Martin, Charlotte, Martin, C., Hosang, Georgina, McGuffin, P., Tansey Katherine E., D'Souza Ursula M., Matthews, Keith, Leonard C Schalkwyk, Schalkwyk Leonard C., Charlotte Martin (533565), Day, RK, Matthews, Kieth, Anne E Farmer, Martin Charlotte, Hosang, G., D'Souza, Ursula M., Charlotte Martin, Powell, T., McGuffin, P, Schalkwyk, LC, Peter McGuffin, Tansey, KE, Georgina M. Hosang (533564), Ursula M D'Souza, Sarah Cohen-Woods, Schalkwyk, Leonard C., D'Souza, U., D'Souza, Ursula M, Keith Matthews, Peter McGuffin (51507), Day, R., Hosang, Georgina M., Katherine E Tansey, McGuffin, Peter, Ursula M. D'Souza (533563), Cohen-Woods, S, McGuffin, Peter W, Schalkwyk, Leonard C, Cohen-Woods, S., Powell, Timothy R., D'Souza, UM, Richard K. Day (533566)   +76 more
core   +1 more source

Association of serum biomarkers with early neurologic improvement after intravenous thrombolysis in ischemic stroke.

PLoS ONE, 2022
BackgroundEarly neurologic improvement (ENI) after intravenous thrombolysis is associated with favorable outcome, but associated serum biomarkers were not fully determined.
Yu Cui, Xin-Hong Wang, Yong Zhao, Shao-Yuan Chen, Bao-Ying Sheng, Li-Hua Wang, Hui-Sheng Chen   +6 more
doaj   +3 more sources

Mechanism‐Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis

Advanced Materials, EarlyView.
Clinically, intermittent hypoxia (IH) is often accompanied by periodontitis, which accelerates cognitive impairment induced by IH. Novel Janus mesoporous gold‐silica nanoformulations (RVG‐Au&mSiO2‐TPP‐VB) enable intranasal delivery, achieve hierarchical targeting to neuronal mitochondria, effectively scavenge reactive oxygen species, inhibit the HIF‐1α/
Kai‐Run Zhang, Tianbao Zhu, An‐Qi Liu, Jia‐Jia Deng, Ya‐Li Han, Sheng‐Cai Qi, Xue Liu, Tian‐Yi Jiang, Ming‐Rui Zhai, Yu‐Ying He, Xiu‐Juan Li, Hong‐Ting Da, Rui Xu, Xiaomin Li, Jun Gao, Yue‐Hua Liu   +15 more
wiley   +1 more source

The C-X-C Motif Chemokine Ligand 5, Which Exerts an Antioxidant Role by Inducing HO-1 Expression, Is C-X-C Motif Chemokine Receptor 2-Dependent in Human Prostate Stroma and Cancer Cells [PDF]

While the C-X-C motif chemokine ligand 5 (CXCL5) is recognized as an inflammatory mediator and a potent attractant for immune cells, its functions within the human prostate remain unclear.
Yu-Hsiang Lin, Hsin-Ching Sung, Kang-Shuo Chang, Wei-Yin Lin, Syue-Ting Chen, Chen-Pang Hou, Horng-Heng Juang, Ke-Hung Tsui, Shu-Yuan Hsu   +8 more
core   +1 more source

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

Macrophage polarization by MSC-derived CXCL12 determines tumor growth

Cellular & Molecular Biology Letters, 2021
Background Phenotypic and functional heterogeneity of macrophages is known to be the main reason for their ability to regulate inflammation and promote tumorigenesis.
Shabnam Babazadeh, Seyed Mahdi Nassiri, Vahid Siavashi, Mohadeseh Sahlabadi, Mostafa Hajinasrollah, Mohamad Zamani-Ahmadmahmudi   +5 more
doaj   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source