Results 71 to 80 of about 55,700 (269)

Effect of immunosuppressive treatment on biomarkers in adult atopic dermatitis patients [PDF]

, 2020
Background: Biomarkers to objectively measure disease severity and predict therapeutic responses are needed in atopic dermatitis (AD). Objective: Primary aim: To identify biomarkers reflecting therapeutic response in patients with AD treated systemically.
Roekevisch, E., Leeflang, M. M. G., Spuls, P. I., Hack, D. P., Schram, M. E., Luiten, R. M., Kezic, S., Middelkamp-Hup, M. A., Res, P. C. J. M., Bos, J. D., Szegedi, K.   +10 more
core   +1 more source

Single-cell transcriptomic analysis reveals differential cell subpopulations and distinct phenotype transition in normal and dissected ascending aorta

Molecular Medicine, 2022
Background Acute thoracic aortic dissection (ATAD) is a fatal condition characterized by tear of intima, formation of false lumen and rupture of aorta. However, the subpopulations of normal and dissected aorta remain less studied. Methods Single-cell RNA
Yu-bin He, Hai-zhen Jin, Jin-long Zhao, Chong Wang, Wen-rui Ma, Jie Xing, Xiao-bin Zhang, Yang-yang Zhang, Huang-dong Dai, Nai-shi Zhao, Jian-feng Zhang, Guan-xin Zhang, Jing Zhang   +12 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Cytokine-armed oncolytic herpes simplex viruses: a game-changer in cancer immunotherapy?

Journal for ImmunoTherapy of Cancer
Cytokines are small proteins that regulate the growth and functional activity of immune cells, and several have been approved for cancer therapy. Oncolytic viruses are agents that mediate antitumor activity by directly killing tumor cells and inducing ...
Howard L Kaufman, Hongbin Wang, Dipongkor Saha, Samuel D Rabkin, Mia Borlongan, Uyen Le, Hans J Nauwynck   +6 more
doaj   +1 more source

Discovery of Exosomes From Tick Saliva and Salivary Glands Reveals Therapeutic Roles for CXCL12 and IL-8 in Wound Healing at the Tick–Human Skin Interface

Frontiers in Cell and Developmental Biology, 2020
Ticks secrete various anti-coagulatory, anti-vasoconstrictory, anti-inflammatory, and anti-platelet aggregation factors in their saliva at the bite site during feeding to evade host immunological surveillance and responses.
Wenshuo Zhou, Faizan Tahir, Joseph Che-Yen Wang, Joseph Che-Yen Wang, Michael Woodson, Michael B. Sherman, Michael B. Sherman, Shahid Karim, Girish Neelakanta, Girish Neelakanta, Hameeda Sultana, Hameeda Sultana, Hameeda Sultana   +12 more
doaj   +1 more source

The N-terminus of CXCR4 splice variants determines expression and functional properties.

PLoS ONE, 2023
C-X-C motif chemokine ligand 12(CXCL12) is an essential chemokine for organ development and homeostasis in multiple tissues. Its receptor, C-X-C chemokine receptor type 4(CXCR4), is expressed on the surface of target cells. The chemokine and receptor are
Hee-Kyung Park, Lan Phuong Nguyen, Thai Uy Nguyen, Minyeong Cho, Huong Thi Nguyen, Sunghoon Hurh, Hong-Rae Kim, Jae Young Seong, Cheol Soon Lee, Byung-Joo Ham, Jong-Ik Hwang   +10 more
doaj   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

Association of chemokine and chemokine receptor expression with the invasion and metastasis of lung carcinoma [PDF]

, 2015
The chemokine system has been reported to be utilized and manipulated by tumor cells in order to promote local tumor growth and distant dissemination. The present study aimed to investigate the expression of three chemokine ligand-receptor axes in lung ...
Liu, Yan, Geng, Hua, Xu, Mei-Lin, Wu, Bing-Quan, Zhong, Hao-Hao   +4 more
core   +1 more source

Results of detected biomarkers in the microarray analysis. [PDF]

, 2022
(A) The scatter plot for detected biomarkers; the X-axis represents the average of log2 serum levels in ENI group, while the Y-axis represents the average of log2 serum levels in Non ENI group; compared with Non ENI group, the gray point represents ...
Hui-Sheng Chen (6691241), Shao-Yuan Chen (571064), Yong Zhao (84950), Li-Hua Wang (552239), Bao-Ying Sheng (14034959), Yu Cui (160305), Xin-Hong Wang (2051134)   +6 more
core   +1 more source