Results 81 to 90 of about 55,700 (269)

Supplementary Table 1 from Chemokine (C-X-C Motif) Ligand 12 Is Associated with Gallbladder Carcinoma Progression and Is a Novel Independent Poor Prognostic Factor

, 2023
<p>PDF file - 45K, Relationship of CXCR4 expression and clinicopathological characteristics of gallbladder carcinoma</p>
Hyo Jin Lee, Jin-Man Kim, Jeong-Ki Min, Deog Yeon Jo, Ha Yon Kim, Yoon Suk Oh, Song Mei Huang, Zhe Long Liang, Jang-Seong Kim, Kwang-Hee Bae, Dong Gwang Lee, Kyungmin Lee, Hyun Jung Lee   +12 more
openaire   +1 more source

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

Advanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen, Jiahui Xie, Yi Liao, Junyu Li, Longqi Liu, Xin Gao, Hongmin Cai   +6 more
wiley   +1 more source

Differential regulation of chemokine (C‐X‐C Motif) ligand 12 by lipopolysacchrides in differentiated and un‐differentiated human THP‐1 cells (835.4)

The FASEB Journal, 2014
Chemokine (C‐X‐C Motif) ligand (CXCL) 12 is a pleiotropic chemokine that act through its receptor CXCR4/7. CXCL12 plays crucial roles in the regulation of autoimmune, inflammation, angiogenesis and cancer development. However, tissues expression, physiological role and regulation of CXCL12 and CXCR4/7 remain largely unclear.
Lu Yu, Liangli Yu, Thomas Wang
openaire   +1 more source

Supplementary Figures 1-3 from Chemokine (C-X-C Motif) Ligand 12 Is Associated with Gallbladder Carcinoma Progression and Is a Novel Independent Poor Prognostic Factor

, 2023
<p>PDF file - 299K, Supplementary Figure 1: Enhanced migration and invasion of GBC cells overexpressing CXCL12. SNU-308 cells were stably transfected with CXCL12 as described in Materials and Methods. Migration (A) and invasion (B) assays were performed as described in Materials and Methods.
Hyo Jin Lee, Jin-Man Kim, Jeong-Ki Min, Deog Yeon Jo, Ha Yon Kim, Yoon Suk Oh, Song Mei Huang, Zhe Long Liang, Jang-Seong Kim, Kwang-Hee Bae, Dong Gwang Lee, Kyungmin Lee, Hyun Jung Lee   +12 more
openaire   +1 more source

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

Transcriptomic analysis identifies CXCL12 as a novel candidate gene for litter size in rabbits [PDF]

Animal Bioscience
Objective The ovary, as an important reproductive organ, tightly regulates the litter size of rabbits through its complex network of genes. This study aims to identify candidate genes related to litter size in rabbits through RNA sequencing and to ...
Zhiyuan Bao, Jie Yang, Jiali Li, Jiawei Cai, Pin Zhai, Pinyi Zhao, Bohao Zhao, Yang Chen, Xinsheng Wu   +8 more
doaj   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Inhibition of HDAC activity leads to a mixed M1/M2 secreation profile of cytokines and chemokines from macrophages. [PDF]

, 2015
Secreted cytokines and NO production were accessed in supernatants from cultures treated with GM-CSF and TSA + GM-CSF groups. Nitric oxide (NO) production correlates with the concentration of nitrites produced in Griess reaction.
Mariana Cabanel (773241), Jose Marques Brito (773245), Felipe Leite de Oliveira (410505), Marcela Freitas Lopes (773244), Katia Carneiro (3467126), Mariela Pires Cabral-Piccin (773243), Maria Cecilia Oliveira-Nunes (773242), Marcia Cury El-Cheikh (773246), Camila Brand (351900)   +8 more
core   +1 more source

Effects of ricin on primary pulmonary alveolar macrophages

Journal of International Medical Research, 2019
Objective We systematically investigated the cytotoxic effects of ricin in primary pulmonary alveolar macrophages (PAMs). Methods Primary PAMs were isolated from BALB/c mice.
Zhendong Guo, Zhongyi Wang, Shanyu Meng, Zongzheng Zhao, Chunmao Zhang, Yingying Fu, Jiaming Li, Xin Nie, Cheng Zhang, Linna Liu, Bing Lu, Jun Qian   +11 more
doaj   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source