Results 91 to 100 of about 55,700 (269)

PGK1 Suppresses CD8+ T Cell‐Mediated Antitumor Immunity Through CCL2/CCR2/Tumor‐Associated Macrophages Axis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PGK1 in tumor cells upregulates CCL2 expression through activation of the AKT/GSK‐3β/β‐catenin signaling axis, thereby promoting the recruitment and M2 polarization of TAMs and ultimately impairing the infiltration and activation of CD8+ T cells within the HCC tumor microenvironment. ABSTRACT Patients with advanced hepatocellular carcinoma (HCC) have a
Xi Liu, Jianpeng Liu, Zhihao Zhang, Xizhi Yu, Junjie Qian, Limin Ding, Qinchuan Wu, Zhe Yang, Xing‐Yu Luo, Xinjiang Ding, Rong Su, Xiaobo Yu, Yiting Qiao, Shengyong Yin, Haiyang Xie, Lin Zhou, Yuanxing Liu, Shusen Zheng   +17 more
wiley   +1 more source

Towards a Total Chemical Synthesis of Human C-C Motif Chemokine Ligand 2 [PDF]

, 2013
Chemokines are cell signalling proteins that promote cellular migration. C-C motif chemokine ligand 2 (CCL2) plays an important role in the inflammatory response, and is involved in the pathogenesis of diseases such as asthma, atherosclerosis and cancer.
LEAR, SAM
core  

Role of TPBG (Trophoblast Glycoprotein) Antigen in Human Pericyte Migratory and Angiogenic Activity [PDF]

, 2019
Objective- To determine the role of the oncofetal protein TPBG (trophoblast glycoprotein) in normal vascular function and reparative vascularization. Approach and Results- Immunohistochemistry of human veins was used to show TPBG expression in vascular ...
Spencer, H. L., Spinetti, Gaia, Alvino, V. V., Reni C., Reni, C., Spencer H. L., Gargioli, C., Cathery, William, Spinetti G., Sala-Newby, G., Gargioli C., Rodriguez-Arabaolaza I., Dang, Z., Vono R., Cathery, W., Spinetti, G., Jover, E., Thomas, A. C., Rowlinson, J., Rodriguez-Arabaolaza, I., Rowlinson J., Angelini G., Vono, R., Dang Z., Thomas, Anita C, Angelini, Gianni, Thomas, Anita C., Madeddu, P., Rodriguez-Arabaolaza, Iker, Alvino V. V., Alvino, Valeria V, Beltrami, A. P., Beltrami A. P., Jover E., Avolio, E., Dang, Zexu, Caporali, Andrea, Fagnano M., Cathery W., Caporali A., Jover, Eva, Vono, Rosa, Avolio E., Sala-Newby, Graciela, Fagnano, M., Caporali, Andrea; id_orcid, Sala-Newby G., Avolio, Elisa, Fagnano, Marco, Reni, Carlotta, Rowlinson, Jonathan, Beltrami, Antonio P., Beltrami, Antonio P, Alvino, Valeria V., Gargioli, Cesare, Thomas A. C., Angelini, G., Madeddu P., Spencer, Helen L., Caporali, A., Spencer, Helen L, Madeddu, Paolo   +61 more
core   +2 more sources

Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome‐Targeted PD‐L1 Degradation

Advanced Science, EarlyView.
A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li, Min Hou, Shasha Sun, Jun Cao, Jian‐Hui Jiang, Jianjun He   +5 more
wiley   +1 more source

Quantitative PCR on left ventricle myocardial tissue of mice with HF 8 weeks after SERCA2a gene excision and 4 weeks after initiation of sustained TLR9 stimulation. [PDF]

, 2015
(A) CXCL2, Chemokine C-X-C motif ligand 2 (B) CXCL10, Chemokine C-X-C motif ligand 10 (C) MCP-1, Monocyte chemotactic protein-1 (D) TNF, Tumor necrosis factor. Statistics were done using Mann Whitney U- test (n = 7–12 per group).
Katrine Alfsnes (616207), Arne Yndestad (224387), Sigve Dhondup Holmen (812740), Muhammad Shakil Ahmed (812741), Solveig Bjærum Haugstad (812739), Leif Erik Vinge (329788), Trine Ranheim (151364), Pål Aukrust (151370), Lars Gullestad (224437), Øystein Sandanger (329789), Yangchen Dhondup (812738), Jan Magnus Aronsen (347485), Ivar Sjaastad (162165), Lili Zhang (120447), Håvard Attramadal (224421), Helge Scott (4898), Geir Christensen (162197)   +16 more
core   +1 more source

Icaritin Improves the Hematopoiesis-Supportive Function of MSCs via A PRDX1–MAPK Axis After Chemotherapy

Engineering
The alleviation of chemotherapy-induced myelosuppression is an integral part of sustained and effective cancer therapy. Although the role of the hematopoietic microenvironment in the regulation of hematopoietic stem/progenitor cells (HSPCs) has been ...
Pengli Huang, Rui Jing, Wendan Zhang, Jun Xia, Xin Luan, Ji Ye, Saisai Tian, Hao Zhang, Qun Wang, Honghong Jiang, Ningbo Wu, Mengting Xu, Guangyong Zheng, Dong Lu, Fei Qian, Tao Cheng, Weian Yuan, Feng Liu, Sanhong Liu, Weidong Zhang   +19 more
doaj   +1 more source

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

ProSiteHunter: A Unified Framework for Sequence‐Based Prediction of Protein‐Nucleic Acid and Protein‐Protein Binding Sites

Advanced Science, EarlyView.
This study proposed a unified sequence‐based framework for protein binding site prediction, which adopted a tri‐track semantic multi‐source feature fusion strategy to effectively capture diverse macromolecular interaction sites and further improved the accuracy of antibody‐antigen interaction prediction.
Dongliang Hou, Qihang Zhen, Zexin Lv, Xinyue Cui, Suhui Wang, Minghua Hou, Zhan Zhou, Xiaogen Zhou, Guijun Zhang   +8 more
wiley   +1 more source

Nine transcripts expressed in caIBDV-infected cells only at 12 hpi. [PDF]

, 2015
The expression level of these nine transcripts increased gradually from 0 to 12 hpi. ENSGALT00000006704: torsin family 1, member B-like mRNA; IYD: iodotyrosine deiodinase; RSAD2: radical SAM domain-containing 2, viperin; MXI1: MAX-interacting protein 1 ...
Frederick C. Leung (452730), Raymond K. Hui (751230)   +1 more
core   +1 more source

A2 astrocyte polarization mediates ketogenic diet protection of blood–central nervous system barriers in experimental autoimmune encephalomyelitis

Neural Regeneration Research
Disruption of the blood–brain barrier and blood-spinal cord barrier is a fundamental pathological feature of multiple sclerosis progression. The ketogenic diet has a high therapeutic potential for patients with multiple sclerosis.
Qianye Zhang, Mingxiao Zheng, Hans-Christian Siebert, Qingpeng Wang, Ruiyan Zhang, Ning Zhang   +5 more
doaj   +1 more source