Results 11 to 20 of about 49,192 (255)

The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease [PDF]

Frontiers in Physiology, 2014
The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic function by mediating the homing of progenitor cells in the bone marrow and regulating their mobilization into peripheral tissues upon injury or stress. Although the CXCL12/
Yvonne eDöring, Lukas ePawig, Christian eWeber, Heidi eNoels   +3 more
doaj   +6 more sources

CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression [PDF]

Cancer and Metastasis Reviews, 2010
Chemokines, small pro-inflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The chemokine CXCL12 (also called stromal-derived factor-1) is an important α-chemokine that binds primarily to its cognate receptor CXCR4 and thus regulates the ...
Xueqing, Sun, Guangcun, Cheng, Mingang, Hao, Jianghua, Zheng, Xiaoming, Zhou, Jian, Zhang, Russell S, Taichman, Kenneth J, Pienta, Jianhua, Wang   +8 more
openaire   +4 more sources

CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis.

PLoS ONE, 2014
Pancreatic ductal adenocarcinoma is an unsolved health problem with nearly 75% of patients diagnosed with advanced disease and an overall 5-year survival rate near 5%.
Ishan Roy, Noah P Zimmerman, A Craig Mackinnon, Susan Tsai, Douglas B Evans, Michael B Dwinell   +5 more
doaj   +3 more sources

The Signaling Duo CXCL12 and CXCR4: Chemokine Fuel for Breast Cancer Tumorigenesis [PDF]

Cancers, 2020
The CXCL12/CXCR4 signaling pathway has emerged in the recent years as a key player in breast cancer tumorigenesis. This pathway controls many aspects of breast cancer development including cancer cell proliferation, motility and metastasis to all target organs.
Karolina A. Zielińska, Vladimir L. Katanaev   +1 more
openaire   +5 more sources

Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4 [PDF]

The FASEB Journal, 2017
The chemokine receptor, CXC chemokine receptor 4 (CXCR4), is selective for CXC chemokine ligand 12 (CXCL12), is broadly expressed in blood and tissue cells, and is essential during embryogenesis and hematopoiesis.
Caucheteux, Stephan, Cecchinato, Valentina, Collins, Paul J., Laufer, Julia M., Legler, Daniel F., Lortat-Jacob, Hugues, Martínez-Muñoz, Laura, McCully, Michelle L., Mellado, Mario, Monneau, Yoan R., Moser, Bernhard, Piguet, Vincent, Purvanov, Vladimir, Santiago, César, Thelen, Marcus, Thelen, Sylvia, Uguccioni, Mariagrazia, Wheeldon, James   +17 more
core   +6 more sources

Inflammation Controls B Lymphopoiesis by Regulating Chemokine CXCL12 Expression [PDF]

The Journal of Experimental Medicine, 2004
Inflammation removes developing and mature lymphocytes from the bone marrow (BM) and induces the appearance of developing B cells in the spleen. BM granulocyte numbers increase after lymphocyte reductions to support a reactive granulocytosis. Here, we demonstrate that inflammation, acting primarily through tumor necrosis factor α (TNFα), mobilizes BM ...
Ueda, Yoshihiro, Yang, Kaiyong, Foster, Sandra J, Kondo, Motonari, Kelsoe, Garnett   +4 more
openaire   +2 more sources

Monomeric structure of the cardioprotective chemokine SDF‐1/CXCL12 [PDF]

Protein Science, 2009
AbstractThe chemokine stromal cell‐derived factor‐1 (SDF‐1/CXCL12) directs leukocyte migration, stem cell homing, and cancer metastasis through activation of CXCR4, which is also a coreceptor for T‐tropic HIV‐1. Recently, SDF‐1 was shown to play a protective role after myocardial infarction, and the protein is a candidate for development of new anti ...
Christopher T, Veldkamp, Joshua J, Ziarek, Jidong, Su, Harihar, Basnet, Richard, Lennertz, Joshua J, Weiner, Francis C, Peterson, John E, Baker, Brian F, Volkman   +8 more
openaire   +2 more sources

Small Neutralizing Molecules to Inhibit Actions of the Chemokine CXCL12 [PDF]

Journal of Biological Chemistry, 2008
The chemokine CXCL12 and the receptor CXCR4 play pivotal roles in normal vascular and neuronal development, in inflammatory responses, and in infectious diseases and cancer. For instance, CXCL12 has been shown to mediate human immunodeficiency virus-induced neurotoxicity, proliferative retinopathy and chronic inflammation, whereas its receptor CXCR4 is
Hachet-Haas, Muriel, Balabanian, Karl, Rohmer, François, Pons, Françoise, Franchet, Christel, Lecat, Sandra, Chow, Ken y C, Dagher, Rania, Gizzi, Patrick, Didier, Bruno, Lagane, Bernard, Kellenberger, Esther, Bonnet, Dominique, Baleux, Françoise, Haiech, Jacques, Parmentier, Marc, Frossard, Nelly, Arenzana-Seisdedos, Fernando, Hibert, Marcel, Galzi, Jean-Luc   +19 more
openaire   +3 more sources

The dimeric form of CXCL12 binds to atypical chemokine receptor 1 [PDF]

Science Signaling, 2021
Biological functions of CXCL12 dimers may be modified by the atypical receptor ACKR1.
Julia C. Gutjahr, Kyler S. Crawford, Davin R. Jensen, Prachi Naik, Francis C. Peterson, Guerric P. B. Samson, Daniel F. Legler, Johan Duchene, Christopher T. Veldkamp, Antal Rot, Brian F. Volkman   +10 more
openaire   +3 more sources

Bioluminescent CXCL12 fusion protein for cellular studies of CXCR4 and CXCR7

BioTechniques, 2009
Chemokine CXCL12 and its two known receptors, CXCR4 and CXCR7, may play a role in diseases including tumor growth and metastasis, atherosclerosis, and HIV infection. Therefore, these molecules may be promising targets for drug development.
Kathryn E. Luker, Mudit Gupta, Gary D. Luker   +2 more
doaj   +1 more source