Results 11 to 20 of about 97,684 (248)

The chemokine, CXCL12, is an independent predictor of poor survival in ovarian cancer [PDF]

British Journal of Cancer, 2012
Background: The chemokine CXCL12 and its cognate receptor, CXCR4, have been implicated in numerous tumour types where expression promotes tumour growth, angiogenesis, metastasis and suppresses tumour immunity.
Rolland, P., Spendlove, I., Scott, I. V., Popple, A., Deen, S., Ramage, J. M., Durrant, L. G.   +6 more
core   +15 more sources

Gene Variations of Chemokine and Chemokine Receptor CXCL12/CXCR4 in Lung Cancer

Journal of Environmental Pathology, Toxicology and Oncology, 2023
Lung cancer is the most common type of cancer in the world and about 1 million people die from lung cancer every year in the world. Inflammation is an important factor in the onset, progression and metastasis of lung cancer. The most important regulators
ÖZBAYER, CANSU, KURT, HÜLYAM, AK, GÜNTÜLÜ, Yağcı, Emine, METİNTAŞ, MUZAFFER, METİNTAŞ, SELMA, YAĞCI, EMİNE   +6 more
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Small neutralizing molecules to inhibit actions of the chemokine CXCL12. [PDF]

Journal of Biological Chemistry, 2008
The chemokine CXCL12 and the receptor CXCR4 play pivotal roles in normal vascular and neuronal development, in inflammatory responses, and in infectious diseases and cancer.
Frossard, N. (Nelly), Dagher, Rania, Gizzi, P. (Patrick), Arenzana-Seisdedos, Fernando, Franchet, C. (Christel), Baleux, F. (Françoise), Haiech, Jacques, Galzi, Jean-Luc, Lecat, Sandra, Arenza-Seisdedos, F. (Fernando), Franchet, Christel, Baleux, Françoise, Gizzi, Patrick, Chow, Ken Y C, Haiech, J. (Jacques), Rohmer, F. (François), Hibert, Marcel, Rohmer, François, Bonnet, Dominique, Parmentier, Marc, Dagher, R. (Rania), Balabanian, Karl, Chow, Ken Y. C., Pons, Françoise, Bonnet, D. (Dominique), Parmentier, M. (Marc), Pons-lebeau, F. (Françoise), Hibert, M. (Marcel), Galzi, J. (Jean-Luc), Lagane, Bernard, Kellenberger, Esther, Lagane, B. (Bernard), Didier, Bruno, Hachet-Haas, M. (Muriel), Lecat, S. (Sandra), Hachet-Haas, Muriel, Didier, B. (Bruno), Kellenberger, E. (Esther), Frossard, Nelly, Balabanian, K. (Karl)   +39 more
core   +4 more sources

The role of the chemokine CXCL12 in osteoclastogenesis

Trends in Endocrinology & Metabolism, 2007
The chemokine CXCL12 (variously termed stromal-derived factor 1 or B cell-stimulating factor) is a highly conserved chemotactic cytokine belonging to the large family of CXC chemokines.
Andrew C.W. Zannettino, Stan Gronthos, Zannettino, A., Gronthos, S.   +3 more
core   +4 more sources

CXCR7 functions as a scavenger for CXCL12 and CXCL11. [PDF]

PLoS ONE, 2010
BackgroundCXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses.
Ulrike Naumann, Elisabetta Cameroni, Monika Pruenster, Harsha Mahabaleshwar, Erez Raz, Hans-Günter Zerwes, Antal Rot, Marcus Thelen   +7 more
doaj   +2 more sources

CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis.

PLoS ONE, 2014
Pancreatic ductal adenocarcinoma is an unsolved health problem with nearly 75% of patients diagnosed with advanced disease and an overall 5-year survival rate near 5%.
Ishan Roy, Noah P Zimmerman, A Craig Mackinnon, Susan Tsai, Douglas B Evans, Michael B Dwinell   +5 more
doaj   +2 more sources

Neutraligands of the chemokine CXCL12 in asthma

, 2013
La liaison de CXCL12 à ses récepteurs CXCR4 et CXCR7 peut-être bloquée par un neutraligand de CXCL12, la chalcone 4, qui présente une activité anti-inflammatoire dans un modèle d’asthme chez la souris.
Daubeuf, Francois
core   +2 more sources

Cxcl12 evolution - subfunctionalization of a ligand through altered interaction with the chemokine receptor. [PDF]

Development, 2011
International audienceThe active migration of primordial germ cells (PGCs) from their site of specification towards their target is a valuable model for investigating directed cell migration within the complex environment of the developing embryo.
Thelen, M., Katsiaryna Tarbashevich, Dörries, Julia, Schwille, Petra, Laguri, Cédric, Brand, Michael, Thelen, S., Laguri, C., Ries, J., Dumstrei, K., Messerschmidt, E. M., Marcus Thelen, Messerschmidt, Esther-Maria, Julia Dörries, Shuizi Rachel Yu, Lortat-Jacob, H., Raz, E., Boldajipour, Bijan, Maria Doitsidou, Cedric Laguri, Esther-Maria Messerschmidt, Jonas Ries, Karin Dumstrei, Bijan Boldajipour, Lortat-Jacob, Hugues, Michael Brand, Brand, M., Thelen, Sylvia, Raz, Erez, Sylvia Thelen, Doitsidou, M., Petra Schwille, Boldajipour, B., Doitsidou, Maria, Yu, Shuizi Rachel, Schwille, P., Tarbashevich, Katsiaryna, Yu, S. R., Ries, Jonas, Erez Raz, Thelen, Marcus, Hugues Lortat-Jacob, Dumstrei, Karin, Tarbashevich, K., Dörries, J.   +44 more
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The chemokine CXCL12 regulates monocyte-macrophage differentiation and RUNX3 expression [PDF]

Blood, 2011
Monocytes are versatile cells that can express different functional programs in response to microenvironmental signals. We show that primary blood monocytes secrete the CXCL12 chemokine, and express the CXCR4 and CXCR7 receptors, leading to an autocrine ...
Ana Estecha, Miguel Ángel Vega, Lorena Sánchez-Martín, Paloma Sánchez-Mateos, Silvia Sánchez-Ramón, Rafael Samaniego   +5 more
core   +4 more sources

Modulation of rat oligodendrocyte precursor cells by the chemokine CXCL12

NeuroReport, 2006
Migration, proliferation, and differentiation of oligodendrocyte precursor cells are essential for the assembly of myelin in the central nervous system.
Nguyen, Dan, Zobel, Franziska, Höpfner, Michael, Maysami, Samaneh, Heine, Sandra, Stangel, Martin, Pitz, Caroline, Hoepfner, Michael   +7 more
core   +4 more sources