Results 11 to 20 of about 33,556 (238)

The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease [PDF]

Frontiers in Physiology, 2014
The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic function by mediating the homing of progenitor cells in the bone marrow and regulating their mobilization into peripheral tissues upon injury or stress. Although the CXCL12/
Christian Weber, Heidi Noels, Yvonne Döring   +2 more
exaly   +8 more sources

The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer [PDF]

Frontiers in Pharmacology, 2020
Chemokines are a family of small, secreted cytokines which regulate a variety of cell functions. The C-X-C motif chemokine ligand 12 (CXCL12) binds to C-X-C chemokine receptor type 4 (CXCR4) and C-X-C chemokine receptor type 7 (CXCR7). The interaction of
David J Riese, Jianzhong Shen
exaly   +5 more sources

Gene Variations of Chemokine and Chemokine Receptor CXCL12/CXCR4 in Lung Cancer

Journal of Environmental Pathology, Toxicology and Oncology, 2023
Lung cancer is the most common type of cancer in the world and about 1 million people die from lung cancer every year in the world. Inflammation is an important factor in the onset, progression and metastasis of lung cancer. The most important regulators
ÖZBAYER, CANSU, KURT, HÜLYAM, AK, GÜNTÜLÜ, Yağcı, Emine, METİNTAŞ, MUZAFFER, METİNTAŞ, SELMA, YAĞCI, EMİNE   +6 more
core   +3 more sources

Small neutralizing molecules to inhibit actions of the chemokine CXCL12. [PDF]

Journal of Biological Chemistry, 2008
The chemokine CXCL12 and the receptor CXCR4 play pivotal roles in normal vascular and neuronal development, in inflammatory responses, and in infectious diseases and cancer.
Frossard, N. (Nelly), Dagher, Rania, Gizzi, P. (Patrick), Arenzana-Seisdedos, Fernando, Franchet, C. (Christel), Baleux, F. (Françoise), Haiech, Jacques, Galzi, Jean-Luc, Lecat, Sandra, Arenza-Seisdedos, F. (Fernando), Franchet, Christel, Baleux, Françoise, Gizzi, Patrick, Chow, Ken Y C, Haiech, J. (Jacques), Rohmer, F. (François), Hibert, Marcel, Rohmer, François, Bonnet, Dominique, Parmentier, Marc, Dagher, R. (Rania), Balabanian, Karl, Chow, Ken Y. C., Pons, Françoise, Bonnet, D. (Dominique), Parmentier, M. (Marc), Pons-lebeau, F. (Françoise), Hibert, M. (Marcel), Galzi, J. (Jean-Luc), Lagane, Bernard, Kellenberger, Esther, Lagane, B. (Bernard), Didier, Bruno, Hachet-Haas, M. (Muriel), Lecat, S. (Sandra), Hachet-Haas, Muriel, Didier, B. (Bruno), Kellenberger, E. (Esther), Frossard, Nelly, Balabanian, K. (Karl)   +39 more
core   +5 more sources

The dimeric form of CXCL12 binds to atypical chemokine receptor 1 [PDF]

Science Signaling, 2021
The pleiotropic chemokine CXCL12 is involved in diverse physiological and pathophysiological processes, including embryogenesis, hematopoiesis, leukocyte migration, and tumor metastasis. It is known to engage the classical receptor CXCR4 and the atypical
Gutjahr, Julia C., Naik, P, Volkman, BF, Duchene, Johan, Rot, A, Rot, Antal, Duchene, J, Jensen, DR, Peterson, Francis C., Volkman, Brian F., Peterson, FC, Jensen, Davin R., Samson, Guerric P. B., Gutjahr, JC, Crawford, Kyler S., Samson, GPB, Legler, DF, Naik, Prachi, Veldkamp, CT, Legler, Daniel F., Crawford, KS   +20 more
core   +4 more sources

Evaluation of CXCL12 and CXCR4 to predict poor survival in lymph node-positive colorectal cancer patients

Polish Journal of Pathology, 2021
It is well known that interactions in the tumour microenvironment are very important in the progression of tumours. We investigated the relationship between chemokine ligand type 12 (CXCL12), chemokine receptor type 4 (CXCR4) and survival in advanced ...
Mehmet Zengin, Nevra Dursun, Kemal Behzatoğlu, Hüsniye Esra Paşaoğlu, Suat Benek   +4 more
doaj   +2 more sources

The role of the chemokine CXCL12 in osteoclastogenesis

Trends in Endocrinology & Metabolism, 2007
The chemokine CXCL12 (variously termed stromal-derived factor 1 or B cell-stimulating factor) is a highly conserved chemotactic cytokine belonging to the large family of CXC chemokines.
Andrew C.W. Zannettino, Stan Gronthos, Zannettino, A., Gronthos, S.   +3 more
core   +4 more sources

The chemokine, CXCL12, is an independent predictor of poor survival in ovarian cancer [PDF]

British Journal of Cancer, 2012
Background: The chemokine CXCL12 and its cognate receptor, CXCR4, have been implicated in numerous tumour types where expression promotes tumour growth, angiogenesis, metastasis and suppresses tumour immunity.
Rolland, P., Spendlove, I., Scott, I. V., Popple, A., Deen, S., Ramage, J. M., Durrant, L. G.   +6 more
core   +6 more sources

CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis.

PLoS ONE, 2014
Pancreatic ductal adenocarcinoma is an unsolved health problem with nearly 75% of patients diagnosed with advanced disease and an overall 5-year survival rate near 5%.
Ishan Roy, Noah P Zimmerman, A Craig Mackinnon, Susan Tsai, Douglas B Evans, Michael B Dwinell   +5 more
doaj   +2 more sources

CXCR7 functions as a scavenger for CXCL12 and CXCL11. [PDF]

PLoS ONE, 2010
BackgroundCXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses.
Ulrike Naumann, Elisabetta Cameroni, Monika Pruenster, Harsha Mahabaleshwar, Erez Raz, Hans-Günter Zerwes, Antal Rot, Marcus Thelen   +7 more
doaj   +2 more sources