The chemokine CXCL12 regulates monocyte-macrophage differentiation and RUNX3 expression [PDF]
Blood, 2011 Monocytes are versatile cells that can express different functional programs in response to microenvironmental signals. We show that primary blood monocytes secrete the CXCL12 chemokine, and express the CXCR4 and CXCR7 receptors, leading to an autocrine ...
Ana Estecha +5 more
core +4 more sources
Modulation of rat oligodendrocyte precursor cells by the chemokine CXCL12
NeuroReport, 2006 Migration, proliferation, and differentiation of oligodendrocyte precursor cells are essential for the assembly of myelin in the central nervous system.
Nguyen, Dan +7 more
core +4 more sources
Cxcl12 evolution - subfunctionalization of a ligand through altered interaction with the chemokine receptor. [PDF]
Development, 2011 International audienceThe active migration of primordial germ cells (PGCs) from their site of specification towards their target is a valuable model for investigating directed cell migration within the complex environment of the developing embryo.
Thelen, M. +44 more
core +4 more sources
Characterization and Validation of Antibodies for Immunohistochemical Staining of the Chemokine CXCL12. [PDF]
J Histochem Cytochem, 2019 Chemokines and their receptors have been implicated in cancer biology. The CXCL12/CXCR4 axis is essential for the homing and retention of hematopoietic stem cells in bone marrow niches, and has a significant role in neonatal development. It is also implicated in multiple facets of cancer biology including metastasis, angiogenesis/neo-vasculogenesis ...
Fricker SP +6 more
europepmc +4 more sources
Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12. [PDF]
ACS Med Chem Lett, 2021 CXCL12, a CXC-type chemokine, binds its receptor CXCR4, and the resulting signaling cascade is essential during development and subsequently in immune function.
Sprague DJ +4 more
europepmc +2 more sources
CXCL12 and CXCL13 as potential biomarkers for disease severity and recurrence in respiratory syncytial virus bronchiolitis [PDF]
Scientific ReportsTo examine chemokine expression in children with Respiratory Syncytial Virus (RSV) bronchiolitis and evaluate its clinical utility for early warning and prognosis. Five hospitalised RSV bronchiolitis children and five matched controls were studied.
Lin Zhang +13 more
doaj +2 more sources
The Role of CXCL12 in Kidney Diseases: A Friend or Foe?
Kidney Diseases, 2021 Background: Chemokines are a family of proteins mainly mediating the homing and migration of various cells. The CXC chemokine CXCL12 is a member of low-weight-molecular chemokines.
Anni Song +3 more
doaj +1 more source
The diagnostic significance of the chemokine CXCL12 in Alzheimer's disease [PDF]
Alzheimer's & Dementia, 2021 AbstractBackgroundA complex relationship between the stromal cell‐derived factor 1 (CXCL12) and dementia, including mild cognitive impairment (MCI) and Alzheimer's disease (AD) has been described in the literature. The chemokine CXCL12 regulates many functions of bone marrow‐derived stem cells and has been implicated in neurogenesis as well as with the
Barbara Mroczko +5 more
openaire +1 more source
A new obligate CXCL4–CXCL12 heterodimer for studying chemokine heterodimer activities and mechanisms
Scientific Reports, 2022 Chemokines form a family of proteins with critical roles in many biological processes in health and disease conditions, including cardiovascular, autoimmune diseases, infections, and cancer.
Khanh T.P. Nguyen +3 more
doaj +1 more source
Biochemistry and Biophysics Reports, 2021 Chemotactic factors locally secreted from tissues regulate leukocyte migration via cell membrane receptors that induce intracellular signals. It has been suggested that neutrophils stimulated by bacterial peptides secrete a secondary stimulant that ...
Kaoru Kurowarabe +3 more
doaj +1 more source