Results 21 to 30 of about 97,684 (248)
Characterization and Validation of Antibodies for Immunohistochemical Staining of the Chemokine CXCL12. [PDF]
J Histochem Cytochem, 2019 Chemokines and their receptors have been implicated in cancer biology. The CXCL12/CXCR4 axis is essential for the homing and retention of hematopoietic stem cells in bone marrow niches, and has a significant role in neonatal development. It is also implicated in multiple facets of cancer biology including metastasis, angiogenesis/neo-vasculogenesis ...
Fricker SP +6 more
europepmc +4 more sources
The role of the chemokine receptor CXCR4 in oral squamous cell carcinoma metastasis [PDF]
, 2010 PhDOral Squamous Cell Carcinoma (OSCC) is the sixth most common cancer worldwide. The greatest cause of mortality and surgical morbidity is due to the common spread of tumour cells from the primary lesion to the lymph nodes of the neck. This pathway is
Collier, Jonathan Marc
core +4 more sources
The diagnostic significance of the chemokine CXCL12 in Alzheimer's disease [PDF]
Alzheimer's & Dementia, 2021 AbstractBackgroundA complex relationship between the stromal cell‐derived factor 1 (CXCL12) and dementia, including mild cognitive impairment (MCI) and Alzheimer's disease (AD) has been described in the literature. The chemokine CXCL12 regulates many functions of bone marrow‐derived stem cells and has been implicated in neurogenesis as well as with the
Barbara Mroczko +5 more
openaire +1 more source
The inflammatory infiltrate of high-grade serous carcinoma omental metastasis [PDF]
, 2014 PhDThe aim of this thesis is to investigate the role of inflammatory infiltrates and chemokines in metastasis of high-grade serous ovarian cancer, HGSC, to the omentum using human tissue biopsies and a 3- dimensional (3D) cell culture model.
Everitt, Gemma Louise Ann
core +4 more sources
The dimeric form of CXCL12 binds to atypical chemokine receptor 1 [PDF]
Science Signaling, 2021 Biological functions of CXCL12 dimers may be modified by the atypical receptor ACKR1.
Julia C. Gutjahr +10 more
openaire +4 more sources
Interactions of the chemokines CXCL11 and CXCL12 in human tumor cells
BMC Cancer, 2022 Abstract Background The chemokines, CXCL12 and CXCL11, are upregulated in tumors from many organs and control their progression. CXCL12 and CXCL11 affect tumor cell functions by either binding their prime receptors, CXCR4 and CXCR3, respectively, and/or CXCR7 as a common second chemokine receptor. In humans, CXCR3 exists
Koch, Christian A +3 more
openaire +5 more sources
Questions about Chemokine and Chemokine Receptor Antagonism in Renal Inflammation [PDF]
, 2010 Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease.
Sayyed, Sufyan Ali +2 more
core +1 more source
Monomeric structure of the cardioprotective chemokine SDF‐1/CXCL12 [PDF]
Protein Science, 2009 AbstractThe chemokine stromal cell‐derived factor‐1 (SDF‐1/CXCL12) directs leukocyte migration, stem cell homing, and cancer metastasis through activation of CXCR4, which is also a coreceptor for T‐tropic HIV‐1. Recently, SDF‐1 was shown to play a protective role after myocardial infarction, and the protein is a candidate for development of new anti ...
Christopher T, Veldkamp +8 more
openaire +2 more sources
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin
Cell Reports, 2019 Summary: Phosphorylation of heptahelical receptors is thought to regulate G protein signaling, receptor endocytosis, and non-canonical signaling via recruitment of β-arrestins.
Friederike Saaber +10 more
doaj +1 more source