CXCR-4 expression by circulating endothelial progenitor cells and SDF-1 serum levels are elevated in septic patients [PDF]
Journal of Inflammation, 2018 Background Endothelial progenitor cell (EPC) numbers are increased in septic patients and correlate with survival. In this study, we investigated, whether surface expression of chemokine receptors and other receptors important for EPC homing is ...
Christian Patry +6 more
doaj +8 more sources
Chemokine Receptor CXCR-2 Initiates Atrial Fibrillation by Triggering Monocyte Mobilization in Mice [PDF]
Hypertension, 2020 Atrial fibrillation (AF) is frequently associated with increased inflammatory response characterized by infiltration of monocytes/macrophages. The chemokine receptor CXCR-2 is a critical regulator of monocyte mobilization in hypertension and cardiac remodeling, but it is not known whether CXCR-2 is involved in the development of ...
Yun-Long Zhang +11 more
openaire +4 more sources
Differential expression of TLR and CXCR genes in mammary HC11 cells challenged with Bacillus cereus and Bacillus subtilis: Implications for mastitis resistance [PDF]
Veterinary WorldBackground and Aim: Mastitis remains a major health challenge in dairy cattle, often caused by Gram-positive pathogens. Toll-like receptors (TLRs) and chemokine receptors (CXCRs) play essential roles in the innate immune response of mammary epithelial ...
Nova Dilla Yanthi +10 more
doaj +2 more sources
Pleiotropic Role of Rainbow Trout CXCRs in Response to Disease and Environment: Insights from Transcriptional Signatures and Structure Analysis [PDF]
BiomoleculesChemokines are cytokines with chemoattractant capacities that exert their physiological functions through the binding of chemokine receptors. Thus, chemokine and receptor complexes exert important roles in regulating development and homeostasis during ...
Zhi-Shuai Hou +12 more
doaj +2 more sources
The Expression of Serglycin Is Required for Active Transforming Growth Factor β Receptor I Tumorigenic Signaling in Glioblastoma Cells and Paracrine Activation of Stromal Fibroblasts via CXCR-2 [PDF]
BiomoleculesSerglycin (SRGN) is a pro-tumorigenic proteoglycan expressed and secreted by various aggressive tumors including glioblastoma (GBM). In our study, we investigated the interplay and biological outcomes of SRGN with TGFβRI, CXCR-2 and inflammatory ...
Dimitra Manou +5 more
doaj +2 more sources
Expression of Functional CCR and CXCR Chemokine Receptors in Podocytes [PDF]
The Journal of Immunology, 2002 AbstractChemokines and their receptors play an important role in the pathogenesis of acute and chronic glomerular inflammation. However, their expression pattern and function in glomerular podocytes, the primary target cells in a variety of glomerulopathies, have not been investigated as of yet.
Huber, Tobias B. +6 more
openaire +3 more sources
A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis. [PDF]
PLoS Computational Biology, 2015 Neutrophils play a central role in eliminating bacterial pathogens, but may also contribute to end-organ damage in sepsis. Interleukin-8 (IL-8), a key modulator of neutrophil function, signals through neutrophil specific surface receptors CXCR-1 and CXCR-
Alexander D Malkin +5 more
doaj +1 more source
The Therapeutic and Prognostic Value of Chemokine Receptors (CXCRs) in Skin Cutaneous Melanoma (SKCM) Progression [PDF]
, 2021 Abstract Introduction:Skin cutaneous melanoma (SKCM) is an aggressive cancer and associates with CXC chemokine receptors (CXCRs). CXCRs is a group of membrane protein involved in tumor initiation, progression, and outcome. However, the therapeutic and prognostic value of CXCRs in SKCM remained elusive.
Sumei Huang +7 more
openaire +1 more source
Risk Stratification in Acute Myeloid Leukemia Using CXCR Gene Signatures: A Bioinformatics Analysis
Frontiers in Oncology, 2020 The role of CXC chemokine receptors in tumors has been an increasingly researched focus in recent years. However, significant prognostic values of CXCR members in acute myeloid leukemia are yet to be explored profoundly. In this study, we firstly made an
Cong Lu +20 more
doaj +1 more source
Comprehensive analysis of CXCR family members in lung adenocarcinoma with prognostic values
BMC Pulmonary Medicine, 2022 Background The expression profiles and molecular mechanisms of CXC chemokine receptors (CXCRs) in Lung adenocarcinoma (LUAD) have been extensively explored.
Lian-Tao Hu +13 more
doaj +1 more source