Results 11 to 20 of about 11,764 (203)

A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice. [PDF]

Journal of Clinical Investigation, 1998
Chronic macrophage-mediated inflammation is central to atherosclerosis. A role of the monocyte chemotactic and activating C-C chemokine JE/monocyte chemotactic protein-1 has been proposed. However, the human C-X-C chemokines growth-regulated oncogene (GROalpha) and IL-8, and their shared receptor, CXCR-2, also can be expressed at sites of chronic ...
W A, Boisvert, R, Santiago, L K, Curtiss, R A, Terkeltaub   +3 more
openaire   +4 more sources

Expression and functional activity of CXCR-4 and CCR-5 chemokine receptors in human thymocytes

Clinical and Experimental Immunology, 2002
SummaryIn this paper we addressed the expression of the HIV co-receptors CXCR-4 and CCR-5 in human thymocytes by phenotypic, molecular and functional approaches. Cytofluorimetric analysis disclosed that CXCR-4 was constitutively expressed by freshly isolated thymocytes (~10 000 molecules/cell in about 30% of thymocytes); the receptor was endowed with ...
R, Zamarchi, P, Allavena, A, Borsetti, L, Stievano, V, Tosello, N, Marcato, G, Esposito, V, Roni, C, Paganin, G, Bianchi, F, Titti, P, Verani, G, Gerosa, A, Amadori   +13 more
exaly   +7 more sources

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

The CXC-Chemokine Neutrophil-Activating Peptide-2 Induces Two Distinct Optima of Neutrophil Chemotaxis by Differential Interaction With Interleukin-8 Receptors CXCR-1 and CXCR-2 [PDF]

Blood, 1997
AbstractThe CXC-chemokines interleukin-8 (IL-8), neutrophil-activating peptide-2 (NAP-2), and melanoma growth-stimulatory activity (MGSA) are chemoattractants with high selectivity for neutrophils. Although IL-8 has been shown to act as an extremely potent mediator, reports on NAP-2 and MGSA are still contradictory. Here we show for the first time that
A, Ludwig, F, Petersen, S, Zahn, O, Götze, J M, Schröder, H D, Flad, E, Brandt   +6 more
openaire   +2 more sources

Preferential Loss of CXCR-2 Receptor Expression and Function in Patients Who Have Undergone Trauma [PDF]

Archives of Surgery, 1999
In response to traumatic injury or infection, human neutrophils are directed to the site of injury or infection by CXC chemokines that signal via 2 receptors, CXCR-1 and CXCR-2. In vitro studies have shown preferential loss of CXCR-2 expression and function after exposure to interleukin 8, N-formyl-methionyl-leucyl-phenylalanine (fMLP), C5a, and tumor ...
G A, Quaid, C, Cave, C, Robinson, M A, Williams, J S, Solomkin   +4 more
openaire   +2 more sources

CXC Chemokines in the Pathogenesis of Pulmonary Disease and Pharmacological Relevance

International Journal of Inflammation, 2022
Chemokines and their receptors play important roles in the pathophysiology of many diseases by regulating the cellular migration of major inflammatory and immune players.
Kayode Komolafe, Maricica Pacurari
doaj   +1 more source

Chemokine Receptors CXCR-1/2 Activate Mitogen-activated Protein Kinase via the Epidermal Growth Factor Receptor in Ovarian Cancer Cells [PDF]

Journal of Biological Chemistry, 2000
Ovarian cancer typically disseminates widely in the abdomen, a characteristic that limits curative therapy. The mechanisms that promote ovarian cancer cell migration are incompletely understood. We studied model SK-OV-3 ovarian cancer cells and observed robust expression of the alpha chemokine receptors CXCR-1 and CXCR-2. Interleukin-8 (IL-8) treatment
G, Venkatakrishnan, R, Salgia, J E, Groopman   +2 more
openaire   +2 more sources

Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors [PDF]

, 2018
Chemokines are secreted proteins that regulate a range of processes in eukaryotic organisms. Interestingly, different chemokine receptors control distinct biological processes, and the same receptor can direct different cellular responses, but the basis ...
Malhotra, Divyanshu, Raz, Erez, Shin, Jimann, Solnica-Krezel, Lilianna   +3 more
core   +2 more sources

Use of Murine CXCR-4 as a Second Receptor by Some T-Cell-Tropic Human Immunodeficiency Viruses [PDF]

Journal of Virology, 1998
ABSTRACTThe human CXCR-4 molecule serves as a second receptor for primary, T-cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV-1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates.
PAROLIN, MARIA CRISTINA, BORSETTI A., CHOE H., FARZAN M., KOLCHINSKY P., HEESEN M., MA Q., GERARD G., PALU', GIORGIO, DORF M. E., SPRINGER T., SODROSKI J.   +11 more
openaire   +3 more sources

Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer [PDF]

, 2017
Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), receptor activator ...
Borzone, Francisco Raúl, Chasseing, Norma Alejandra, Choi, Hosoon, Davies, Kevin Mauro, de Luján Calcagno, María, Feldman, Leonardo, García Rivello, Hernán, Giorello, María Belén, Howard, Scott C., Labovsky, Vivian, Martinez, Leandro Marcelo, Matas, Ayelen, Wernicke, Alejandra   +12 more
core   +2 more sources