Results 31 to 40 of about 11,764 (203)

SH2-inositol phosphatase 1 negatively influences early megakaryocyte progenitors. [PDF]

PLoS ONE, 2008
The SH2-containing-5'inositol phosphatase-1 (SHIP) influences signals downstream of cytokine/chemokine receptors that play a role in megakaryocytopoiesis, including thrombopoietin, stromal-cell-derived-Factor-1/CXCL-12 and interleukin-3.
Lia E Perez, Caroline Desponts, Nancy Parquet, William G Kerr   +3 more
doaj   +1 more source

PAKing up to the endothelium [PDF]

, 2009
Angiogenesis recapitulates the growth of blood vessels that progressively expand and remodel into a highly organized and stereotyped vascular network. During adulthood, endothelial cells that formed the vascular wall retain their plasticity and can be ...
Armelle Le Guelte, Eva Maria, Galan Moya, Julie Gavard   +3 more
core   +6 more sources

HMGB1: The Central Cytokine for all Lymphoid Cells

Frontiers in Immunology, 2013
High mobility group box 1 (HMGB1) is a leaderless cytokine, like the IL-1 and FGF family members, that has primary roles within the nucleus and the cytosol.
Guanqiao eLi, Xiaoyan eLiang, Michael Thomas Lotze   +2 more
doaj   +1 more source

Apoptotic effects of antilymphocyte globulins on human pro-inflammatory CD4+CD28- T-cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Pro-inflammatory, cytotoxic CD4(+)CD28(-) T-cells with known defects in apoptosis have been investigated as markers of premature immuno-senescence in various immune-mediated diseases.
Christina Duftner, Christian Dejaco, Paul Hengster, Klaudija Bijuklic, Michael Joannidis, Raimund Margreiter, Michael Schirmer   +6 more
doaj   +1 more source

Identification of chemokine receptors as potential modulators of endocrine resistance in oestrogen receptor–positive breast cancers [PDF]

, 2014
Introduction Endocrine therapies target oestrogenic stimulation of breast cancer (BC) growth, but resistance remains problematic. Our aims in this study were (1) to identify genes most strongly associated with resistance to endocrine therapy by ...
A Boudot, A Levoye, AE Gururaj, AH Evans, AK Dunbier, Anita Dunbier, Aradhana Rani, AS Coutts, B Györffy, BC Nair, CA Moore, CM Chan, DG Duda, EA Musgrove, F Andre, GJ Sabnis, H Shankar, H Zheng, J Kang, J Xu, JM Burns, K Hattermann, K Sauvé, KE Luker, LA Martin, LA Martin, LA Martin, Lesley-Ann Martin, LV Rhodes, M Dowsett, Mitch Dowsett, MJ Ellis, MR Hara, MT Weigel, N Lapteva, OE Hawkins, Qiong Gao, R Santen, RD Berahovich, Ricardo Ribas, RK Singh, S Ali, S Masamura, S Masri, S Rajagopal, SE Ghayad, SM DeWire, Sunil Pancholi, TJ Frederick, TN Hartmann, V Lakshmikanthan, Y Shi, YC Su, Z Liang, Zara Ghazoui   +54 more
core   +1 more source

CXCR Gene and its Association with Mastitis Resistance in Cattle- a Review

International Journal of Bio-Resource and Stress Management, 2023
Genes associated with immune responses of mammary gland are potential genetic markers because of their importance in mastitis. Neutrophil functions are potential genetic markers for mastitis, as neutrophil migration from blood to the sites of infection ...
Mahesh. S. Dige, G. R. Gowane, L. S. Kokate, Sunil Kumar B. V., Bharat Bhushan   +4 more
doaj  

High Mobility Group Box 1 Expression in Oral Inflammation and Regeneration

Frontiers in Immunology, 2020
High mobility group box 1 (HMGB1) is a non-histone DNA-binding protein of about 30 kDa. It is released from a variety of cells into the extracellular milieu in response to inflammatory stimuli and acts on specific cell-surface receptors, such as ...
Keisuke Yamashiro, Hidetaka Ideguchi, Hiroaki Aoyagi, Chiaki Yoshihara-Hirata, Anna Hirai, Risa Suzuki-Kyoshima, Yao Zhang, Hidenori Wake, Masahiro Nishibori, Tadashi Yamamoto, Shogo Takashiba   +10 more
doaj   +1 more source

The Critical Role and Therapeutic Potential of the CXCR Family in Skin Diseases

Frontiers in Bioscience-Landmark
The C-X-C chemokine receptors (CXCR) chemokine receptor family, consisting of seven primary members (CXCR1–CXCR7), is crucial in regulating immune cell recruitment, angiogenesis, cellular proliferation, and maintaining skin homeostasis and immune ...
Jin Xu, Chaoyi Wang, Yundong Xu, Bingchen Li, Jianzhou Ye   +4 more
doaj   +1 more source

Expression and Clinical Significance of Various Checkpoint Molecules in Advanced Osteosarcoma: Possibilities for Novel Immunotherapy

Orthopaedic Surgery, 2023
Objectives The fact that studies on anti‐programmed cell death 1 (PD‐1) or its relevant ligand 1 (PD‐L1) have yielded such few responses greatly decreases the confidence in immunotherapy with checkpoint inhibitors for advanced osteosarcoma.
Lu Xie, Chenglong Chen, Xin Liang, Jie Xu, Xin Sun, Kunkun Sun, Rongli Yang, Xiaodong Tang, Wei Guo   +8 more
doaj   +1 more source

Outgroup, alignment and modelling improvements indicate that two TNFSF13-like genes existed in the vertebrate ancestor [PDF]

, 2017
Peer reviewedPublisher ...
Dooley, Helen, Pettinello, Rita, Redmond, Anthony K   +2 more
core   +1 more source