Cytosolic Phospholipase A2α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation [PDF]
PLoS ONE, 2013 Acknowledgments: We thank Dr. Robert Barkley and Charis Uhlson for mass spectrometry analysis. Funding: This work was supported by grants from the National Institutes of Health HL34303 (to C.C.L., R.C.M. and D.L.B), DK54741 (to J.V.B.), GM5322 (to D.L.W.)
Bonventre, Joseph V. +9 more
core +16 more sources
Ubiquitination of CXCR7 Controls Receptor Trafficking [PDF]
PLoS ONE, 2012 The chemokine receptor CXCR7 binds CXCL11 and CXCL12 with high affinity, chemokines that were previously thought to bind exclusively to CXCR4 and CXCR3, respectively. Expression of CXCR7 has been associated with cardiac development as well as with tumor growth and progression.
Canals, M. +5 more
openaire +5 more sources
Imaging Ligand-Dependent Activation of CXCR7
Neoplasia, 2009 Chemokine CXCL12 is proposed to promote multiple steps in growth of primary tumors and progression to metastatic disease in more than 20 different cancers. Functions of CXCL12 previously were believed to be controlled only by receptor CXCR4, but CXCR7 was recently identified as a second receptor for this chemokine.
Kathryn E. Luker +4 more
openaire +4 more sources
CXCR7 Functions as a Scavenger for CXCL12 and CXCL11 [PDF]
PLoS ONE, 2010 CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is controversial.
Naumann, Ulrike +7 more
openaire +5 more sources
CXCR7 promoted proliferation, migration and invasion in HCC Cells by inactivating Hippo-YAP signaling. [PDF]
Discov OncolBackground CXCR7 (ACKR3) has been well-supported as a promoter of growth and metastasis in hepatocellular carcinoma (HCC). Both CXCR7 and Hippo signaling play roles in organ development.
Wang G, Pang Y, Li N, Hui Y, Jin D.
europepmc +2 more sources
CXCR7-TAGLN2 protein complex regulates invasion and metastasis in papillary thyroid carcinoma: a potential therapeutic target. [PDF]
Front ImmunolObjectiveTo investigate the expression and clinical significance of CXCR7 and TAGLN2 in papillary thyroid carcinoma (PTC), and to explore the molecular mechanisms underlying the interaction between CXCR7 and TAGLN2 in regulating PTC invasion and ...
Zeng C, Wang F, Huang Y, Zhang H.
europepmc +2 more sources
CXCR7 Is Involved in Human Oligodendroglial Precursor Cell Maturation [PDF]
PLOS ONE, 2016 Differentiation of oligodendroglial precursor cells (OPCs), a crucial prerequisite for central nervous system (CNS) remyelination in diseases such as Multiple Sclerosis (MS), is modulated by a multitude of extrinsic and intrinsic factors. In a previous study we revealed that the chemokine CXCL12 stimulates rodent OPC differentiation via activation of ...
Kremer, David +6 more
openaire +5 more sources
Activation of CXCR7 exerts an inhibitory effect on adipogenesis through regulation of β-arrestin2/Wnt and AKT signalling. [PDF]
AdipocyteCXCR7, an alternative receptor for the inflammatory chemokine SDF-1, is involved in cell proliferation and migration. Recent studies have reported that CXCR7 also plays a role in adipose tissue.
Sun S +6 more
europepmc +2 more sources
CXCL12/CXCR4/CXCR7 axis in placenta tissues of patients with placenta previa
Open Life Sciences, 2023 CXCR4 and CXCR7 have been revealed to be receptors of CXCL12. This research was designed to probe the expression of chemokine CXCL12 and its receptors CXCR4 and CXCR7 in placental tissues of patients with placenta previa and the effect of CXCL12/CXCR4 ...
Wu Xia, Wang Ying, Li Min
doaj +1 more source
CXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor
Scientific Reports, 2021 Most seven transmembrane receptors (7TMRs) are G protein-coupled receptors; however, some 7TMRs evoke intracellular signals through β-arrestin as a biased receptor.
Masato Ishizuka +20 more
doaj +1 more source