Results 11 to 20 of about 6,925 (209)
CXCR7 functions as a scavenger for CXCL12 and CXCL11. [PDF]
PLoS ONE, 2010 BackgroundCXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses.
Ulrike Naumann +7 more
doaj +7 more sources
Imaging Ligand-Dependent Activation of CXCR7 [PDF]
Neoplasia: An International Journal for Oncology Research, 2009 Chemokine CXCL12 is proposed to promote multiple steps in growth of primary tumors and progression to metastatic disease in more than 20 different cancers.
Kathryn E. Luker +4 more
doaj +4 more sources
CXCR7 contributes to the aggressive phenotype of cholangiocarcinoma cells [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2019 Development of cholangiocarcinoma (CCA) is dependent on a cross-talk with stromal cells, which release different chemokines including CXCL12, that interacts with two different receptors, CXCR4 and CXCR7.
Pinzani, M +17 more
core +12 more sources
CXCR7 controls competition for recruitment of β-arrestin 2 in cells expressing both CXCR4 and CXCR7. [PDF]
PLoS ONE, 2014 Chemokine CXCL12 promotes growth and metastasis of more than 20 different human cancers, as well as pathogenesis of other common diseases. CXCL12 binds two different receptors, CXCR4 and CXCR7, both of which recruit and signal through the cytosolic ...
Jennifer J Linderman +20 more
core +5 more sources
Ubiquitination of CXCR7 controls receptor trafficking. [PDF]
PLoS ONE, 2012 The chemokine receptor CXCR7 binds CXCL11 and CXCL12 with high affinity, chemokines that were previously thought to bind exclusively to CXCR4 and CXCR3, respectively.
Meritxell Canals +5 more
doaj +5 more sources
Profiling of Cxcl12 receptors, Cxcr4 and Cxcr7 in murine testis development and a spermatogenic depletion model indicates a role for Cxcr7 in controlling Cxcl12 activity. [PDF]
PLoS ONE, 2014 In mice the chemokine Cxcl12 and its receptor Cxcr4 participate in maintenance of the spermatogonial population during postnatal development. More complexity arises since Cxcl12 also binds to the non-classical/atypical chemokine receptor Cxcr7.
Birgit Westernströer +5 more
doaj +2 more sources
CXCR7 impact on CXCL12 biology and disease
Trends in Molecular Medicine, 2014 It is known that the chemokine receptor CXCR7 (RDC1) can be engaged by both chemokines CXCL12 (SDF-1) and CXCL11 (I-TAC), but the exact expression pattern and function of CXCR7 is controversial.
Sánchez-Mateos, Paloma +2 more
core +4 more sources
CXCR7 Protein Is Not Expressed on Human or Mouse Leukocytes [PDF]
The Journal of Immunology, 2010 Since the discovery that CXCR7 binds to CXCL12/SDF-1α, the role of CXCR7 in CXCL12-mediated biological processes has been under intensive scrutiny. However, there is no consensus in the literature on the expression of CXCR7 protein by peripheral blood ...
Lin Gan +12 more
core +3 more sources
CXCR7 protein expression in human adult brain and differentiated neurons. [PDF]
PLoS ONE, 2011 BACKGROUND:CXCR7 and CXCR4 are receptors for the chemokine CXCL12, which is involved in essential functions of the immune and nervous systems. Although CXCR7 transcripts are widely expressed throughout the central nervous system, little is known about ...
Saori Shimizu +4 more
doaj +2 more sources
Science Signaling, 2011 CXCR7 heterodimerizes with CXCR4, leading to preferential activation of β-arrestin–mediated signaling pathways.
Elizabeth M. Adler
core +2 more sources