Results 11 to 20 of about 6,662 (210)

CXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor

Scientific Reports, 2021
Most seven transmembrane receptors (7TMRs) are G protein-coupled receptors; however, some 7TMRs evoke intracellular signals through β-arrestin as a biased receptor.
Masato Ishizuka, Mutsuo Harada, Seitaro Nomura, Toshiyuki Ko, Yuichi Ikeda, Jiaxi Guo, Satoshi Bujo, Haruka Yanagisawa-Murakami, Masahiro Satoh, Shintaro Yamada, Hidetoshi Kumagai, Yoshihiro Motozawa, Hironori Hara, Takayuki Fujiwara, Tatsuyuki Sato, Norifumi Takeda, Norihiko Takeda, Kinya Otsu, Hiroyuki Morita, Haruhiro Toko, Issei Komuro   +20 more
doaj   +2 more sources

CXCR7 contributes to the aggressive phenotype of cholangiocarcinoma cells [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2019
Development of cholangiocarcinoma (CCA) is dependent on a cross-talk with stromal cells, which release different chemokines including CXCL12, that interacts with two different receptors, CXCR4 and CXCR7. The aim of the present study was to investigate the role of CXCR7 in CCA cells.
Alessandra Gentilini, Alessandra Caligiuri, Chiara Raggi, Krista Rombouts, Massimo Pinzani, Giulia Lori, Margherita Correnti, Pietro Invernizzi, Elisabetta Rovida, Nadia Navari, Sabina Di Matteo, Domenico Alvaro, Jesus M. Banales, Pedro Rodrigues, Carlotta Raschioni, Matteo Donadon, Luca Di Tommaso, Fabio Marra   +17 more
core   +9 more sources

CXCR7 Controls Competition for Recruitment of β-Arrestin 2 in Cells Expressing Both CXCR4 and CXCR7

PLoS ONE, 2014
Chemokine CXCL12 promotes growth and metastasis of more than 20 different human cancers, as well as pathogenesis of other common diseases. CXCL12 binds two different receptors, CXCR4 and CXCR7, both of which recruit and signal through the cytosolic adapter protein β-arrestin 2.
Nathaniel L Coggins, Danielle Trakimas, S Laura Chang, Anna Ehrlich, Paramita Ray, Kathryn E Luker, Jennifer J Linderman, Gary D Luker   +7 more
openaire   +5 more sources

CXCR7 Protein Is Not Expressed on Human or Mouse Leukocytes [PDF]

The Journal of Immunology, 2010
Abstract Since the discovery that CXCR7 binds to CXCL12/SDF-1α, the role of CXCR7 in CXCL12-mediated biological processes has been under intensive scrutiny. However, there is no consensus in the literature on the expression of CXCR7 protein by peripheral blood cells.
Robert D, Berahovich, Brian A, Zabel, Mark E T, Penfold, Susanna, Lewén, Yu, Wang, Zhenhua, Miao, Lin, Gan, Jaime, Pereda, Jessica, Dias, Igor I, Slukvin, Kathleen E, McGrath, Juan C, Jaen, Thomas J, Schall   +12 more
openaire   +3 more sources

Profiling of Cxcl12 receptors, Cxcr4 and Cxcr7 in murine testis development and a spermatogenic depletion model indicates a role for Cxcr7 in controlling Cxcl12 activity. [PDF]

PLoS ONE, 2014
In mice the chemokine Cxcl12 and its receptor Cxcr4 participate in maintenance of the spermatogonial population during postnatal development. More complexity arises since Cxcl12 also binds to the non-classical/atypical chemokine receptor Cxcr7.
Birgit Westernströer, Nicole Terwort, Jens Ehmcke, Joachim Wistuba, Stefan Schlatt, Nina Neuhaus   +5 more
doaj   +2 more sources

Advances in CXCR7 Modulators [PDF]

Pharmaceuticals, 2020
CXC chemokine receptor 7 (CXCR7) is a G-protein-coupled receptor that signals through the β-arrestin pathway. Its ligands include interferon-inducible T cell α chemoattractant (CXCL11) and stromal cell-derived factor-1 (CXCL12). It interacts with CXCR4, and the two are associated with various cancers, as well as other disease states such as coronary ...
Nicole Lounsbury
openaire   +4 more sources

Expression and functional heterogeneity of chemokine receptors CXCR4 and CXCR7 in primary patient-derived glioblastoma cells. [PDF]

PLoS ONE, 2013
Glioblastoma (GBM) is the most common primary brain tumor in adults. The poor prognosis and minimally successful treatments of these tumors indicates a need to identify new therapeutic targets. Therapy resistance of GBMs is attributed to heterogeneity of
Che Liu, Kien Pham, Defang Luo, Brent A Reynolds, Parvinder Hothi, Gregory Foltz, Jeffrey K Harrison   +6 more
doaj   +2 more sources

CXCR7 protein expression in human adult brain and differentiated neurons. [PDF]

PLoS ONE, 2011
BACKGROUND:CXCR7 and CXCR4 are receptors for the chemokine CXCL12, which is involved in essential functions of the immune and nervous systems. Although CXCR7 transcripts are widely expressed throughout the central nervous system, little is known about ...
Saori Shimizu, Michael Brown, Rajarshi Sengupta, Mark E Penfold, Olimpia Meucci   +4 more
doaj   +2 more sources

Atypical Roles of the Chemokine Receptor ACKR3/CXCR7 in Platelet Pathophysiology

Cells, 2022
The manifold actions of the pro-inflammatory and regenerative chemokine CXCL12/SDF-1α are executed through the canonical GProteinCoupledReceptor CXCR4, and the non-canonical ACKR3/CXCR7.
Madhumita Chatterjee
doaj   +2 more sources

Expression and function of CXCR7 in the mouse forebrain

Journal of Neuroimmunology, 2010
The chemokine CXCL12/CXCR4 signaling system is important for the regulation of neuron migration in the developing forebrain. In particular it is crucial for correct distribution of Cajal-Retzius cells and migration of cortical interneurons. Here we investigated the expression of CXCR7, the second receptor for CXCL12, in comparison to CXCR4.
Mc, Tiveron, Boutin, C., Daou, P., Moepps, B., Cremer, H.   +4 more
openaire   +6 more sources