Results 41 to 50 of about 6,662 (210)
CXCR7/p-ERK-Signaling Is a Novel Target for Therapeutic Vasculogenesis in Patients with Coronary Artery Disease. [PDF]
PLoS ONE, 2016 Coronary artery disease (CAD) is characterized by insufficient vasculogenic response to ischemia, which is typically accompanied by dysfunction of endothelial outgrowth cells (EOCs).
Zheng Cao +7 more
doaj +1 more source
CXCL12, CXCR4 and CXCR7 expression in brain metastases [PDF]
Cancer Biology & Therapy, 2009 Brain metastases occur in about 25% of patients who die of cancer. The most common sources of brain metastases in adults are lung, breast, kidney, colorectal cancer and melanoma. The chemokine/receptor system CXCL12/CXCR4 plays a key role in multiple biological functions; among these, homing of neoplastic cells from the primary site to the target and ...
Paola Gaviani +9 more
openaire +3 more sources
CXCR7 is highly expressed in acute lymphoblastic leukemia and potentiates CXCR4 response to CXCL12. [PDF]
PLoS ONE, 2014 Recently, a novel CXCL12-binding receptor, has been identified. This CXCL12-binding receptor commonly known as CXCR7 (CXC chemokine receptor 7), has lately, based on a novel nomenclature, has received the name ACKR3 (atypical chemokine receptor 3).
Rita de Cássia Carvalho Melo +7 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2010 Background In spite of recent advances in diagnostic and therapeutic measures, the prognosis of hepatocellular carcinoma (HCC) patients remains poor.
Li Fan +6 more
doaj +1 more source
Cell & Bioscience, 2022 Background Chemokine CXC motif receptor 7 (CXCR7) is an atypical G protein-coupled receptor (GPCR) that signals in a biased fashion. CXCL12/CXCR7 biased signal has been reported to play crucial roles in multiple stages of colorectal cancer (CRC). However,
Mahan Si +7 more
doaj +1 more source
Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system
Nature Communications, 2023 Chemokine receptors constitute an important subfamily of G protein-coupled receptors (GPCRs), and they are critically involved in a broad range of immune response mechanisms.
Parishmita Sarma +16 more
doaj +1 more source
, 2014 A, Representative immunocytofluorescence image for CXCR7 (red) in HBMECs. Nuclei are stained with DAPI (blue). B, Flow cytometry analysis for CXCR7 in HBMECs.
Kevin A. Walter (607333) +2 more
core +1 more source
, 2018 (A) Patients bearing CXCR7+ tumors showed significantly higher OS than patients bearing CXCR7- tumors. (B) Patients bearing CXCR4+CXCR7+ tumors also showed significantly higher OS than patients bearing CXCR4+CXCR7- tumors.
Miguel Alcoceba (3805117) +14 more
core +1 more source
Elucidation of CXCR7-Mediated Signaling Events and Inhibition of CXCR4-Mediated Tumor Cell Transendothelial Migration by CXCR7 Ligands [PDF]
The Journal of Immunology, 2009 Abstract CXCR7 binds chemokines CXCL11 (I-TAC) and CXCL12 (SDF-1) but does not act as a classical chemoattractant receptor. Using CCX771, a novel small molecule with high affinity and selectivity for CXCR7, we found that, although CXCR7 is dispensable for “bare filter” in vitro chemotaxis, CXCR7 plays an essential role in the CXCL12 ...
Brian A, Zabel +13 more
openaire +2 more sources
Scientific Reports, 2017 The atypical C-X-C chemokine receptor 7 (CXCR7) has been implicated in supporting aggressive cancer phenotypes in several cancers including prostate cancer.
James J. Hoy +3 more
doaj +1 more source