Results 61 to 70 of about 6,925 (209)
Expression of the new CXCL12 receptor, CXCR7, in gliomas [PDF]
Cancer Biology & Therapy, 2011 Gliomas are very invasive brain tumors with poor prognosis and therefore any attempt to limit tumor cell dissemination in the brain is expected to improve glioma treatment. The recent deorphanization of CXCR7 as additional receptor for CXCL12 and CXCL11 has raised key issues on its interaction with the CXCL12/CXCR4 axis as a mechanism to modulate ...
C. Calatozzolo +11 more
openaire +4 more sources
Diagnostic Pathology, 2019 Background Lipopolysaccharide (LPS) from Helicobacter pylori (HP) plays an important role in gastric cancer occurrence and development. Toll-like receptor 4 (TLR4) and myeloid differential protein-2 (MD-2) are also reported to be involved in gastric ...
Nan Li +6 more
doaj +1 more source
Overexpression of CXCR7 accelerates tumor growth and metastasis of lung cancer cells
Respiratory Research, 2020 Background Under physiological conditions, CXCL12 modulates cell proliferation, survival, angiogenesis, and migration mainly through CXCR4. Interestingly, the newly discovered receptor CXCR7 for CXCL12 is highly expressed in many tumor cells as well as ...
Huan Liu +8 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka +3 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 19, Page 5732-5751, October 2026.Abstract Cardiovascular disease (CVD) remains the leading global cause of death, driven by complex mechanisms, in which chronic inflammation plays a central role. Inflammatory pathways contribute to all stages of CVD, from endothelial dysfunction and plaque formation to erosion, rupture and myocardial injury.
Shreya Mahabhashyam +4 more
wiley +1 more source
Stem Cell Research & Therapy, 2018 CXCR4 was the first receptor identified for CXCL12, but a second receptor, CXCR7, has also been described and its function in hematopoietic cells remains unknown.
Rita de Cassia Carvalho Melo +3 more
doaj +1 more source
Food Frontiers, Volume 7, Issue 5, September 2026.Cinnamaldehyde derived from Cinnamomum species exerts multitarget anticancer effects by promoting oxidative stress, mitochondrial dysfunction, apoptosis, cell‐cycle arrest, autophagy, and epigenetic changes, and by suppressing mitogen‐activated protein kinase (MAPK), phosphoinositide 3‐kinase/protein kinase B/mechanistic target of rapamycin (PI3K/Akt ...
Gervason Moriasi +6 more
wiley +1 more source
MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.The current systematic review revealed that stromal cell‐derived factor‐1α (SDF‐1α)‐gene‐activated scaffolds have a beneficial impact on promoting SDF‐1α gene expression and protein production. However, this effect is not observed for vascular endothelial growth factor (VEGF) gene expression and protein quantity and endothelial formation, which may be ...
Tungki Pratama Umar +3 more
wiley +1 more source
Proposed model for regulation of CXCR7 trafficking.
, 2012 CXCR7 requires ubiquitination of the Lys residues of its C-tail in order to reach the cell surface. Receptor activation by CXCL12 and subsequent phosphorylation of the C-terminal Ser/Thr residues results in β-arrestin recruitment by CXCR7 and receptor ...
Meritxell Canals (175821) +5 more
core +1 more source
Exploring the CXCR4/CXCR7/CXCL12 Axis in Primary Desmoid Tumors
, 2023 Background Desmoid tumors have an extremely variable natural history. The uncertainty behind desmoid behavior reflects the complexity, which subtends its development and non-linear advancement.
Pasqualini, Fabio +7 more
core +1 more source