Results 71 to 80 of about 10,649 (214)

The emerging role of chemokines and chemokine receptors in the biological and clinical behaviour of pituitary neuroendocrine tumours: An exploratory transcriptomic study

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Abstract The chemokine network in the microenvironment of pituitary neuroendocrine tumours (PitNETs) may modulate tumour biology, aggressiveness, and treatment responses. We aimed to study the role of various chemokines and chemokine receptors in defining PitNET phenotype and clinical outcomes.
Ana Luísa Silva, Sayka Barry, Ana Hipólito, Mariana de Griné Severino, Rita Joaquim, Charlotte Hall, Tiago Oliveira, Dolores López‐Presa, Gonçalo Borrecho, Francisco Tortosa, Ema Nobre, Claudia C. Faria, Márta Korbonits, Pedro Marques   +13 more
wiley   +1 more source

Stem cell highways: signalling beats trafficking? [PDF]

, 2008
status ...
Abelev, B. I., Planinić, Mirko, Poljak, Nikola, Zuo, J. X.   +3 more
core   +4 more sources

Frequent NPM1 mutation, monoblastic/monocytic origin and prognostic significance of organ and system involvement in myeloid sarcoma: a multicenter study

The Journal of Pathology: Clinical Research, Volume 12, Issue 2, March 2026.
Abstract Myeloid sarcoma (MS) is a tumorous extramedullary proliferation of blast or blast equivalent cells (e.g., promonocytes or promyelocytes). The most frequent cutaneous presentation is often referred to as leukemia cutis (LC). These lesions, especially without the clinical context of a known bone marrow disease, pose a differential diagnostic ...
Alex Jenei, Béla Kajtár, Tamás László, Hazem A Juratli, Livia Vida, Ágota Szepesi, Réka Mózes, Botond Timár, Jörg Halter, Stefan Dirnhofer, Alexandar Tzankov   +10 more
wiley   +1 more source

Drug-releasing mesenchymal cells strongly suppress B16 lung metastasis in a syngeneic murine model [PDF]

, 2015
Mesenchymal stromal cells (MSCs) are considered an important therapeutic tool in cancer therapy. They possess intrinsic therapeutic potential and can also be in vitro manipulated and engineered to produce therapeutic molecules that can be delivered to ...
Alessandri, Giulio, Artuso, Simona, Benetti, Anna, Berenzi, Angiola, Bonomi, Arianna, Caruso, Arnaldo, Ceccarelli, Piero, Ceserani, Valentina, Ciusani, Emilio, Coccè, Valentina, Dessy, Enrico, Dossena, Marta, Ferri, Anna, Leonetti, Carlo, Mazzuca, Pietro, Orlandi, Augusto, Parati, Eugenio, Pascucci, Luisa, Passeri, Daniela, Pessina, Augusto, Portolani, Nazario, Sisto, Francesca   +21 more
core   +2 more sources

CXCR7 participates in CXCL12-mediated migration and homing of leukemic and normal hematopoietic cells

Stem Cell Research & Therapy, 2018
CXCR4 was the first receptor identified for CXCL12, but a second receptor, CXCR7, has also been described and its function in hematopoietic cells remains unknown.
Rita de Cassia Carvalho Melo, Karla Priscila Viera Ferro, Adriana da Silva Santos Duarte, Sara Teresinha Olalla Saad   +3 more
doaj   +1 more source

Traditional Chinese Medicine as an Integrative Adjunct in Oncology Perioperative Practice: Analgesia, Immune Modulation, and Translational Challenges

Medicine Bulletin, Volume 2, Issue 2, Page 184-204, March 2026.
ABSTRACT Traditional Chinese medicine (TCM), including herbal analgesic adjuvants and acupuncture‐based interventions, has gained increasing attention as an integrative strategy for perioperative pain management in oncology. Bioactive phytochemicals—such as terpenoids, flavonoids, alkaloids, and polyphenols—exert multimodal pharmacological effects ...
Yuqin Tang, Zheng Luo, Xu Zhao, Yongqiang Zhang, Mingyang Sun, Jiaqiang Zhang   +5 more
wiley   +1 more source

Allosteric peptide regulators of chemokine receptors CXCR4 and CXCR7 [PDF]

Biochemical Pharmacology, 2013
The chemokine CXCL12 and its shared seven-transmembrane receptors CXCR4 and CXCR7 regulate diseases including cancer, atherosclerosis, autoimmunity, and HIV infection, making these molecules promising drug targets. These molecules also control key processes in normal development and physiology, suggesting the need to selectively modulate CXCR4 and/or ...
Anna, Ehrlich, Paramita, Ray, Kathryn E, Luker, Elias J, Lolis, Gary D, Luker   +4 more
openaire   +2 more sources

Endothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells [PDF]

, 2014
Background:Mature circulating endothelial cells (CEC) are surrogate markers of endothelial damage. CEC measured in patients with advanced cancer are thought not only to derive from damaged normal vasculature (n-CEC ...
A Ouhtit, AI Chapoval, AW Griffioen, B Croix St, C Verhoef, D J Grunhagen, D Lemke, DM McDonald, F Bertolini, F Dignat-George, GN Naumov, HR Lijnen, I Yamato, J Hagendoorn, J Kraan, J Kraan, J Kraan, J W Gratama, JA Nagy, JL Rowand, K Broll, K Hida, KH Plate, L Zimmerlin, M Crisan, MH Strijbos, N Maishi, P Carmeliet, P Steinberger, P van den Broek, PK Goon, PL Crispen, R Minhajat, R Wurth, S Seaman, S Sleijfer, SE Duff, TJ Roth, W Taal, X Qin, X Zang, Y Sun, YQ Xiong   +42 more
core   +4 more sources

CXCR7/ACKR3-targeting ligands interfere with X7 HIV-1 and HIV-2 entry and replication in human host cells

Heliyon, 2018
Chemokine receptors CCR5 and CXCR4 are considered the main coreceptors for initial HIV infection, replication and transmission, and subsequent AIDS progression.
Thomas D'huys, Sandra Claes, Tom Van Loy, Dominique Schols   +3 more
doaj   +1 more source

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang, Ling Jiang, Yibo Hu, Chuhan Fu, Jinhua Huang, Jing Chen, Qinghai Zeng   +6 more
wiley   +1 more source