Results 71 to 80 of about 6,662 (210)

Allosteric peptide regulators of chemokine receptors CXCR4 and CXCR7 [PDF]

Biochemical Pharmacology, 2013
The chemokine CXCL12 and its shared seven-transmembrane receptors CXCR4 and CXCR7 regulate diseases including cancer, atherosclerosis, autoimmunity, and HIV infection, making these molecules promising drug targets. These molecules also control key processes in normal development and physiology, suggesting the need to selectively modulate CXCR4 and/or ...
Anna, Ehrlich, Paramita, Ray, Kathryn E, Luker, Elias J, Lolis, Gary D, Luker   +4 more
openaire   +2 more sources

Exploring the CXCR4/CXCR7/CXCL12 Axis in Primary Desmoid Tumors

, 2023
Background Desmoid tumors have an extremely variable natural history. The uncertainty behind desmoid behavior reflects the complexity, which subtends its development and non-linear advancement.
Pasqualini, Fabio, Grizzi, Fabio, Quagliuolo, Vittorio Lorenzo, Baccalini, Edoardo Andrea, Renne, Salvatore Lorenzo, Cananzi, Ferdinando Carlo Maria, Borroni, Elena Monica, Colombo, Piergiuseppe   +7 more
core   +1 more source

The emerging role of chemokines and chemokine receptors in the biological and clinical behaviour of pituitary neuroendocrine tumours: An exploratory transcriptomic study

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Abstract The chemokine network in the microenvironment of pituitary neuroendocrine tumours (PitNETs) may modulate tumour biology, aggressiveness, and treatment responses. We aimed to study the role of various chemokines and chemokine receptors in defining PitNET phenotype and clinical outcomes.
Ana Luísa Silva, Sayka Barry, Ana Hipólito, Mariana de Griné Severino, Rita Joaquim, Charlotte Hall, Tiago Oliveira, Dolores López‐Presa, Gonçalo Borrecho, Francisco Tortosa, Ema Nobre, Claudia C. Faria, Márta Korbonits, Pedro Marques   +13 more
wiley   +1 more source

The role of chemokine receptor CXCR7 in lung cancer

Clinical Oncology and Cancer Research, 2010
OBJECTIVE To investigate whether CXCL12 and its receptor, CXCR7, play a role in lung cancer invasion and metastasis.METHODS Western blot and immunocytochemistry were used to detect CXCR7 protein expression in 8 lung cancer cell lines, EKVX, HOP62, HOP92, NCI-H23, NCI-H226, NCI-H322M, NCI-H446, and A549, and cell migration experiment was conducted to ...
Jun LIU, Fu-rong ZHANG, Yue LI, Chang-li WANG   +3 more
openaire   +2 more sources

Proposed model for regulation of CXCR7 trafficking.

, 2012
CXCR7 requires ubiquitination of the Lys residues of its C-tail in order to reach the cell surface. Receptor activation by CXCL12 and subsequent phosphorylation of the C-terminal Ser/Thr residues results in β-arrestin recruitment by CXCR7 and receptor ...
Meritxell Canals (175821), Rob Leurs (120648), Sabrina de Munnik (120632), Mitchell K. L. Han (175829), Danny J. Scholten (175825), Martine J. Smit (120656)   +5 more
core   +1 more source

Frequent NPM1 mutation, monoblastic/monocytic origin and prognostic significance of organ and system involvement in myeloid sarcoma: a multicenter study

The Journal of Pathology: Clinical Research, Volume 12, Issue 2, March 2026.
Abstract Myeloid sarcoma (MS) is a tumorous extramedullary proliferation of blast or blast equivalent cells (e.g., promonocytes or promyelocytes). The most frequent cutaneous presentation is often referred to as leukemia cutis (LC). These lesions, especially without the clinical context of a known bone marrow disease, pose a differential diagnostic ...
Alex Jenei, Béla Kajtár, Tamás László, Hazem A Juratli, Livia Vida, Ágota Szepesi, Réka Mózes, Botond Timár, Jörg Halter, Stefan Dirnhofer, Alexandar Tzankov   +10 more
wiley   +1 more source

Knockdown of CXCR7 by RNA interference.

, 2014
HBMECs stably infected with CXCR7-targeted shRNA or scrambled control shRNA lentiviruses were subjected to qPCR, Western blot and flow cytometry analysis, respectively, as described in “Materials and Methods”.
Kevin A. Walter (607333), Yang Liu (4829), Eleanor Carson-Walter (607332)   +2 more
core   +1 more source

Alteration of CXCR7 expression mediated by TLR4 promotes tumor cell proliferation and migration in human colorectal carcinoma. [PDF]

PLoS ONE, 2011
The link between inflammation and colorectal carcinoma has been acknowledged. However, the impact of bacterial lipopolysaccharide (LPS) binding to Toll-like receptor 4 (TLR4) on chemokine receptors in human colorectal carcinoma cells still remains to be ...
Huanbai Xu, Qiong Wu, Shipeng Dang, Min Jin, Jingwei Xu, Yiji Cheng, Minglin Pan, Yugang Wu, Chunhui Zhang, Yanyun Zhang   +9 more
doaj   +1 more source

Traditional Chinese Medicine as an Integrative Adjunct in Oncology Perioperative Practice: Analgesia, Immune Modulation, and Translational Challenges

Medicine Bulletin, Volume 2, Issue 2, Page 184-204, March 2026.
ABSTRACT Traditional Chinese medicine (TCM), including herbal analgesic adjuvants and acupuncture‐based interventions, has gained increasing attention as an integrative strategy for perioperative pain management in oncology. Bioactive phytochemicals—such as terpenoids, flavonoids, alkaloids, and polyphenols—exert multimodal pharmacological effects ...
Yuqin Tang, Zheng Luo, Xu Zhao, Yongqiang Zhang, Mingyang Sun, Jiaqiang Zhang   +5 more
wiley   +1 more source

Mechanisms of CXCR7 induction in malignant melanoma development

Oncology Letters, 2017
Malignant melanoma (MM) is a highly malignant skin tumor. The mechanism of MM pathogenesis and its signaling pathways are not well characterized. C-X-C chemokine receptor type 7 (CXCR7) has been reported to regulate cancer cell invasion. The present study sought to investigate the effects of CXCR7 on MM development.
Li, Xiao-Jing, Liu, Pai, Tian, Wei-Wei, Li, Zhi-Feng, Liu, Bao-Guo, Sun, Jian-Fang   +5 more
openaire   +3 more sources