Results 71 to 80 of about 6,925 (209)

Proteomic profile of CSF obtained at the time of diagnosis determines amyotrophic lateral sclerosis progression and survival: CXCL7 levels in disease prognosis and survival

Brain Pathology, Volume 36, Issue 5, September 2026.
Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira, Yaiza López‐Sampere, Pol Mengod‐Soler, Mario Peña‐Fonteboa, Carla Marco, Alejandro Caravaca‐Puchades, Raúl Domínguez, Juan Francisco Vázquez‐Costa, Enrique Santamaría, Joaquín Fernández‐Irigoyen, María J. Colomina, Isabel León Moreno, Antonio Martínez Yélamos, Sergio Martínez Yélamos, Gabriel Santpere, Elia Obis, Manuel Portero‐Otín, Gerard Piñol‐Ripoll, Mónica Povedano, Pol Andrés‐Benito   +19 more
wiley   +1 more source

CXCR7 detection in MS tissue.

, 2016
(A-F) CXCR7 staining revealed receptor expression on cells in control brains (B) and different regions of the MS brain including demyelinated (E; DM) and remyelinating (F; RM) lesions as well as active white matter lesions (D).
David Kremer (444311), Jack Antel (448163), Patrick Küry (444316), Hans-Peter Hartung (112650), Tanja Kuhlmann (377301), Peter Göttle (444312), Qiao-Ling Cui (448161)   +6 more
core   +1 more source

Knockdown of CXCR7 by RNA interference.

, 2014
HBMECs stably infected with CXCR7-targeted shRNA or scrambled control shRNA lentiviruses were subjected to qPCR, Western blot and flow cytometry analysis, respectively, as described in “Materials and Methods”.
Kevin A. Walter (607333), Yang Liu (4829), Eleanor Carson-Walter (607332)   +2 more
core   +1 more source

Elucidation of CXCR7-Mediated Signaling Events and Inhibition of CXCR4-Mediated Tumor Cell Transendothelial Migration by CXCR7 Ligands [PDF]

The Journal of Immunology, 2009
Abstract CXCR7 binds chemokines CXCL11 (I-TAC) and CXCL12 (SDF-1) but does not act as a classical chemoattractant receptor. Using CCX771, a novel small molecule with high affinity and selectivity for CXCR7, we found that, although CXCR7 is dispensable for “bare filter” in vitro chemotaxis, CXCR7 plays an essential role in the CXCL12 ...
Brian A, Zabel, Yu, Wang, Susanna, Lewén, Robert D, Berahovich, Mark E T, Penfold, Penglie, Zhang, Jay, Powers, Bretton C, Summers, Zhenhua, Miao, Bin, Zhao, Ali, Jalili, Anna, Janowska-Wieczorek, Juan C, Jaen, Thomas J, Schall   +13 more
openaire   +2 more sources

CXCL12 enhances angiogenesis through CXCR7 activation in human umbilical vein endothelial cells

Scientific Reports, 2017
Angiogenesis is the process by which new vessels form from existing vascular networks. Human umbilical vein endothelial cells (HUVECs) may contribute to the study of vascular repair and angiogenesis. The chemokine CXCL12 regulates multiple cell functions,
Min Zhang, Lisha Qiu, Yanyan Zhang, Dongsheng Xu, Jialin C. Zheng, Li Jiang   +5 more
doaj   +1 more source

CXCR7 Is Involved in Human Oligodendroglial Precursor Cell Maturation. [PDF]

PLoS ONE, 2016
Differentiation of oligodendroglial precursor cells (OPCs), a crucial prerequisite for central nervous system (CNS) remyelination in diseases such as Multiple Sclerosis (MS), is modulated by a multitude of extrinsic and intrinsic factors.
David Kremer, Qiao-Ling Cui, Peter Göttle, Tanja Kuhlmann, Hans-Peter Hartung, Jack Antel, Patrick Küry   +6 more
doaj   +1 more source

Endothelial Atypical Receptors for Chemoattractants in Lung Immune Surveillance

European Journal of Immunology, Volume 56, Issue 8, August 2026.
Control of chemokine gradients within tissues is achieved by atypical chemokine receptors (ACKRs). The lungs require tightly regulated leukocyte recruitment for effective host defense while preventing tissue damage. In this context, ACKRs expressed by lung endothelial cells are emerging as critical regulators of leukocyte trafficking and inflammatory ...
Mattia Laffranchi, Eleonora Bonanni, Francesca Sozio, Miriam Turchetti, Giuseppe Sciumè, Marcus Thelen, Annalisa Del Prete, Raffaella Bonecchi, Silvano Sozzani   +8 more
wiley   +1 more source

Role of Chemokine Receptor CXCR7 in Adipocyte Physiology and Disease

, 2022
Objective—Chemokines and chemokine receptors have long been shown to play important roles in inflammation, obesity, and type II diabetes. CXCR7 is characterized as an atypical chemokine receptor whose function as a signaling or non-signaling scavenger ...
Shi, Yi
core  

Alteration of CXCR7 expression mediated by TLR4 promotes tumor cell proliferation and migration in human colorectal carcinoma. [PDF]

PLoS ONE, 2011
The link between inflammation and colorectal carcinoma has been acknowledged. However, the impact of bacterial lipopolysaccharide (LPS) binding to Toll-like receptor 4 (TLR4) on chemokine receptors in human colorectal carcinoma cells still remains to be ...
Huanbai Xu, Qiong Wu, Shipeng Dang, Min Jin, Jingwei Xu, Yiji Cheng, Minglin Pan, Yugang Wu, Chunhui Zhang, Yanyun Zhang   +9 more
doaj   +1 more source

Characterizing the SASP‐Dependent Paracrine Spreading of Senescence Between Human Brain Cell Types

Aging Cell, Volume 25, Issue 8, August 2026.
In this paper, we characterized the brain cell‐type‐specific SASP and defined the directionality of a paracrine spreading of senescence phenotypes. We unraveled ligand‐receptor pairs underlying this spreading and showed that inhibiting this interaction ameliorates senescence dissemination.
Taylor Russo, Markus Riessland
wiley   +1 more source