Results 91 to 100 of about 6,662 (210)

Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings, Serbülent Ünsal, Mathieu Rappas, Matthew Barnes, Maria Waldhoer, Ben Holland, Martin Culka   +6 more
wiley   +1 more source

2012 AACR Special Conference on Advances in Prostate Cancer Research

, 2012
CXCR7 was recently identified as the second member of the chemokine receptor family to bind stromal derived factor-1α (SDF-1α), a chemokine which is known to influence the establishment of cancer metastasis.
Kiss, Debra L., Windus, Louisa C. E., Avery, Vickey M.   +2 more
core   +1 more source

Exosomes in Hypertrophic Scars and Keloids: Mechanisms and Therapeutic Potentials—A Narrative Review

Journal of Cosmetic Dermatology, Volume 25, Issue 2, February 2026.
ABSTRACT Background Hypertrophic scars and keloids, types of pathological scars, arise from dysregulated wound healing, marked by abnormal fibroblast activation and excessive extracellular matrix (ECM) deposition. Current treatments have high recurrence rates and side effects, necessitating targeted therapies. Exosomes, extracellular vesicles mediating
Mengke Wu, Jianfeng Zhang, Na Xiong, Yixiao Ma, Lingling Yong, Huaxu Liu, Qin Guo   +6 more
wiley   +1 more source

Lentivirus-mediated shRNA targeting CXCR7 effectively silenced CXCR7 in MOLT4 and Jurkat cells.

, 2014
A) Quantitative expression of CXCR7 mRNA in cells relative to the shControl cells. mRNA expression levels of CXCR7 were normalized by HPRT and GAPDH endogenous control. Results were analyzed using 2−ΔΔCT. CXCR7 mRNA expression was reduced in MOLT4 cells (
Mariana Ozello Baratti (517831), Paula de Melo Campos (517833), Carolina Louzão Bigarella (517830), Rita de Cássia Carvalho Melo (517828), Patrícia Favaro (517832), Sara Teresinha Olalla Saad (517834), Ana Leda Longhini (517829), Fabiola Traina (143689)   +7 more
core   +1 more source

Bevacizumab in ovarian cancer: Clinical data and predictive and prognostic biomarkers

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Evidence supporting bevacizumab in ovarian cancer and predictive biomarkers: highlighting opportunities to improve patient selection and advance personalised treatment strategies. Abstract Angiogenesis, driven by the vascular endothelial growth factor (VEGF)/VEGFR signalling axis under hypoxic conditions, is one of the hallmarks of ovarian cancer (OC),
Maria Rosaria Lamia, Erica Perri, Gustavo Baldassarre, Sandro Pignata, Chiara D'Alessio, Davide Limongello, Francesca Basso‐Valentina   +6 more
wiley   +1 more source

CXCR7/CXCR3 tail switch alters ubiquitination properties of the receptors.

, 2012
(A) Immunoprecipitation experiments were performed in cells expressing chimeric receptors consisting on CXCR7 with CXCR3 C-terminus (CXCR7-X3) or the reciprocal CXCR3 with CXCR7 C-terminus (CXCR3-X7).
Meritxell Canals (175821), Rob Leurs (120648), Sabrina de Munnik (120632), Mitchell K. L. Han (175829), Danny J. Scholten (175825), Martine J. Smit (120656)   +5 more
core   +1 more source

The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells

Molecular Cancer, 2011
Background Migration of metastatic tumor cells from the bloodstream into lymph nodes is thought to be facilitated by expression of the chemokine receptors CCR7, CXCR4 and, for B cell-derived tumors, CXCR5. Expression of their respective chemokine ligands
Jaén Juan C, Berahovich Robert D, Lewén Susanna, Zabel Brian A, Schall Thomas J   +4 more
doaj   +1 more source

The Endothelial Cell Perspective in Pulmonary Fibrosis: From Cell Fate Decisions, Intercellular Communication, and EndoMT to Emerging Therapies

Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.
Pulmonary fibrosis (PF) is a progressive fibrotic interstitial lung disease characterized by aberrant activation of myofibroblasts and excessive deposition of extracellular matrix. In light of the complexity of its pathogenesis and the limited availability of approved antifibrotic drugs, PF remains a refractory lung disease imposing a substantial ...
Danni Chen, Fei Xiang, Halime Nayir Büyükşahin   +2 more
wiley   +1 more source

Discovery of Amantamide, a Selective CXCR7 Agonist from Marine Cyanobacteria

, 2019
CXCR7 plays an emerging role in several physiological processes. A linear peptide, amantamide (1), was isolated from marine cyanobacteria, and the structure was determined by NMR and mass spectrometry.
Danmeng Luo (1433326), Jia-Lei Yan (2546707), Sarath P. Gunasekera (2206474), Valerie J. Paul (307783), Chenglong Li (129885), Tao Ye (302804), Xiao Liang (185891), Hendrik Luesch (1274358), Lilibeth A. Salvador-Reyes (4640938), Mohammad A. Rezaei (5521748)   +9 more
core   +1 more source

CXCR7 limits interaction of CXCR4 and β-arrestin 2 in CXCR4⁺-CXCR7⁺ cells.

, 2014
(A and B) Model outputs for CXCL12-dependent recruitment of β-arrestin 2 specifically to CXCR4 (A) or CXCR7 (B) in CXCR4+-CXCR7+ MDA-MB-231 cells. (C and D) Experimental data for recruitment of β-arrestin 2-CBC to CXCR4-CBRN (C) or CXCR7-CBGN (D) in ...
Nathaniel L. Coggins (572350), Anna Ehrlich (287213), Jennifer J. Linderman (234330), Gary D. Luker (54248), Danielle Trakimas (572351), Kathryn E. Luker (54244), S. Laura Chang (572352), Paramita Ray (572353)   +7 more
core   +1 more source