Results 81 to 90 of about 10,649 (214)

Mechanisms of CXCR7 induction in malignant melanoma development

Oncology Letters, 2017
Malignant melanoma (MM) is a highly malignant skin tumor. The mechanism of MM pathogenesis and its signaling pathways are not well characterized. C-X-C chemokine receptor type 7 (CXCR7) has been reported to regulate cancer cell invasion. The present study sought to investigate the effects of CXCR7 on MM development.
Li, Xiao-Jing, Liu, Pai, Tian, Wei-Wei, Li, Zhi-Feng, Liu, Bao-Guo, Sun, Jian-Fang   +5 more
openaire   +3 more sources

CXCR7 stimulates MAPK signaling to regulate hepatocellular carcinoma progression [PDF]

Cell Death & Disease, 2014
AbstractThe CXCL12/CXCR4 axis has been posited widely to have significant roles in many primary tumors and metastases. It is known that CXCR7 can also be engaged by CXCL12, but the exact function of CXCR7 is controversial. This prompted us to investigate the expression, specific function and signal transduction of CXCR7 in hepatocellular carcinoma (HCC)
Lin, L, Han, M-M, Wang, F, Xu, L-L, Yu, H-X, Yang, P-Y   +5 more
openaire   +2 more sources

LPS-induced CXCR7 expression promotes gastric Cancer proliferation and migration via the TLR4/MD-2 pathway

Diagnostic Pathology, 2019
Background Lipopolysaccharide (LPS) from Helicobacter pylori (HP) plays an important role in gastric cancer occurrence and development. Toll-like receptor 4 (TLR4) and myeloid differential protein-2 (MD-2) are also reported to be involved in gastric ...
Nan Li, Huanbai Xu, Yurong Ou, Zhenzhong Feng, Qiong Zhang, Qing Zhu, Zhaogen Cai   +6 more
doaj   +1 more source

Overexpression of CXCR7 accelerates tumor growth and metastasis of lung cancer cells

Respiratory Research, 2020
Background Under physiological conditions, CXCL12 modulates cell proliferation, survival, angiogenesis, and migration mainly through CXCR4. Interestingly, the newly discovered receptor CXCR7 for CXCL12 is highly expressed in many tumor cells as well as ...
Huan Liu, Qian Cheng, Dong-sheng Xu, Wen Wang, Zheng Fang, Dong-dong Xue, Ya Zheng, Alex H. Chang, Yan-jun Lei   +8 more
doaj   +1 more source

CXC Chemokine‐Driven Vascular Reprogramming: Modulating Tumor Vasculature to Boost Therapeutic Response

Advanced Science, Volume 13, Issue 11, 23 February 2026.
Tumor vascular remodeling is discussed from a chemokine‐centered perspective. This review summarizes the bidirectional, temporal, and tissue‐specific roles of CXC chemokines in regulating vascular function and immune accessibility. A functional vascular normalization score is introduced as a conceptual framework to integrate dynamic vascular and immune
Hongdan Chen, Yinde Huang, Juntong Wu, Ziying Yi, Yao Li, Zeyu Yang, Fan Zhang, Chong Li   +7 more
wiley   +1 more source

Tumor angiogenic switch determines sustained proliferative malignant transformation in tumorigenesis and overlaps with para-inflammatory phenomena [PDF]

, 2015
Contextual BCR-ABL tyrosine kinase over-activity determines in formulated fashion the emergence of proliferation and anti-apoptosis that arise largely as derived phenomena of otherwise homeostatic mechanisms of the c-ABL gene within hematopoietic ...
Agius, Lawrence M.
core  

Luminescence- and fluorescence-based complementation assays to screen for GPCR oligomerization : current state of the art [PDF]

, 2019
G protein-coupled receptors (GPCRs) have the propensity to form homo- and heterodimers. Dysfunction of these dimers has been associated with multiple diseases, e.g., pre-eclampsia, schizophrenia, and depression, among others.
Crans, René, Saini, Deepak K, Stove, Christophe, Vasudevan, Lakshmi, Wouters, Elise   +4 more
core   +1 more source

Aberrant proliferation in CXCR7+ endothelial cells via degradation of the retinoblastoma protein. [PDF]

PLoS ONE, 2013
Angiogenesis is a critical factor in the growth and dissemination of solid tumors. Indeed, tumor vasculature is abnormal and contributes to the development and spread of malignancies by creating a hostile microenvironment.
Jennifer E Totonchy, Jessica M Osborn, Sara Botto, Lisa Clepper, Ashlee V Moses   +4 more
doaj   +1 more source

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

CXCR7 contributes to the aggressive phenotype of cholangiocarcinoma cells [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2019
Development of cholangiocarcinoma (CCA) is dependent on a cross-talk with stromal cells, which release different chemokines including CXCL12, that interacts with two different receptors, CXCR4 and CXCR7. The aim of the present study was to investigate the role of CXCR7 in CCA cells.
Alessandra Gentilini, Alessandra Caligiuri, Chiara Raggi, Krista Rombouts, Massimo Pinzani, Giulia Lori, Margherita Correnti, Pietro Invernizzi, Elisabetta Rovida, Nadia Navari, Sabina Di Matteo, Domenico Alvaro, Jesus M. Banales, Pedro Rodrigues, Carlotta Raschioni, Matteo Donadon, Luca Di Tommaso, Fabio Marra   +17 more
openaire   +7 more sources