Results 81 to 90 of about 6,662 (210)

CXC chemokine receptor 7 ameliorates renal fibrosis by inhibiting β-catenin signaling and epithelial-to-mesenchymal transition in tubular epithelial cells

Renal Failure
Renal fibrosis is a common feature of various chronic kidney diseases. However, the underlying mechanism remains poorly understood. The CXC chemokine receptor (CXCR) family plays a role in renal fibrosis; however, the detailed mechanisms have not been ...
Ping Meng, Chunli Liu, Jingchun Li, Ping Fang, Bo Yang, Wei Sun, Yunfang Zhang   +6 more
doaj   +1 more source

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang, Ling Jiang, Yibo Hu, Chuhan Fu, Jinhua Huang, Jing Chen, Qinghai Zeng   +6 more
wiley   +1 more source

Role of Chemokine Receptor CXCR7 in Adipocyte Physiology and Disease

, 2022
Objective—Chemokines and chemokine receptors have long been shown to play important roles in inflammation, obesity, and type II diabetes. CXCR7 is characterized as an atypical chemokine receptor whose function as a signaling or non-signaling scavenger ...
Shi, Yi
core  

CXC Chemokine‐Driven Vascular Reprogramming: Modulating Tumor Vasculature to Boost Therapeutic Response

Advanced Science, Volume 13, Issue 11, 23 February 2026.
Tumor vascular remodeling is discussed from a chemokine‐centered perspective. This review summarizes the bidirectional, temporal, and tissue‐specific roles of CXC chemokines in regulating vascular function and immune accessibility. A functional vascular normalization score is introduced as a conceptual framework to integrate dynamic vascular and immune
Hongdan Chen, Yinde Huang, Juntong Wu, Ziying Yi, Yao Li, Zeyu Yang, Fan Zhang, Chong Li   +7 more
wiley   +1 more source

CXCL12 enhances angiogenesis through CXCR7 activation in human umbilical vein endothelial cells

Scientific Reports, 2017
Angiogenesis is the process by which new vessels form from existing vascular networks. Human umbilical vein endothelial cells (HUVECs) may contribute to the study of vascular repair and angiogenesis. The chemokine CXCL12 regulates multiple cell functions,
Min Zhang, Lisha Qiu, Yanyan Zhang, Dongsheng Xu, Jialin C. Zheng, Li Jiang   +5 more
doaj   +1 more source

High expression of CXCR4, CXCR7 and SDF-1 predicts poor survival in renal cell carcinoma

World Journal of Surgical Oncology, 2012
Background Chemokines and their receptors are known to play important roles in the tumorigenesis of many malignancies. The aim of this study was to evaluate the prognostic impact of the expression of the chemokine SDF-1 and its receptors CXCR4 and CXCR7 ...
Wang Linhui, Chen Wei, Gao Li, Yang Qing, Liu Bing, Wu Zhenjie, Wang Yang, Sun Yinghao   +7 more
doaj   +1 more source

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

Cxcr7 Controls Neuronal Migration by Regulating Chemokine Responsiveness [PDF]

Neuron, 2011
The chemokine Cxcl12 binds Cxcr4 and Cxcr7 receptors to control cell migration in multiple biological contexts, including brain development, leukocyte trafficking, and tumorigenesis. Both receptors are expressed in the CNS, but how they cooperate during migration has not been elucidated.
Sánchez-Alcañiz, Juan Antonio, Haege, Sammy, Mueller, Wiebke, Pla, Ramón, Mackay, Fabienne, Schulz, Stefan, López-Bendito, Guillermina, Stumm, Ralf, Marín Parra, Óscar   +8 more
openaire   +3 more sources

CXCR4 and CXCR7 Have Distinct Functions in Regulating Interneuron Migration

, 2011
SummaryCXCL12/CXCR4 signaling is critical for cortical interneuron migration and their final laminar distribution. No information is yet available on CXCR7, a newly defined CXCL12 receptor.
Gregory B. Potter, Dianna Crawford, Guangnan Li, Wang, Yanling, Li, Guangnan, Yanling Wang, Jason E. Long, Samuel J. Pleasure, Potter, Gregory B., Behrens, Timothy, Long, Jason E., Amelia Stanco, Timothy Behrens, Rubenstein, John L.R., Crawford, Dianna, Pleasure, Samuel J., John L.R. Rubenstein, Stanco, Amelia   +17 more
core   +1 more source

CXCR7 expression in diffuse large B-cell lymphoma identifies a subgroup of CXCR4+ patients with good prognosis.

PLoS ONE, 2018
The CXCR4/CXCL12 axis has been extensively associated with different types of cancer correlating with higher aggressiveness and metastasis. In diffuse large B-cell lymphoma (DLBCL), the expression of the chemokine receptor CXCR4 is involved in the ...
María José Moreno, Alberto Gallardo, Silvana Novelli, Ana Mozos, Marc Aragó, Miguel Ángel Pavón, María Virtudes Céspedes, Víctor Pallarès, Aïda Falgàs, Miguel Alcoceba, Oscar Blanco, Marcos Gonzalez-Díaz, Jorge Sierra, Ramon Mangues, Isolda Casanova   +14 more
doaj   +1 more source