Results 81 to 90 of about 6,925 (209)
PLoS ONE, 2018 The CXCR4/CXCL12 axis has been extensively associated with different types of cancer correlating with higher aggressiveness and metastasis. In diffuse large B-cell lymphoma (DLBCL), the expression of the chemokine receptor CXCR4 is involved in the ...
María José Moreno +14 more
doaj +1 more source
FEBS Open Bio, Volume 16, Issue 7, Page 1244-1258, July 2026.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
Advanced Science, Volume 13, Issue 38, 9 July 2026.Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral +7 more
wiley +1 more source
Renal FailureRenal fibrosis is a common feature of various chronic kidney diseases. However, the underlying mechanism remains poorly understood. The CXC chemokine receptor (CXCR) family plays a role in renal fibrosis; however, the detailed mechanisms have not been ...
Ping Meng +6 more
doaj +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, Volume 13, Issue 35, 24 June 2026.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Lentivirus-mediated shRNA targeting CXCR7 effectively silenced CXCR7 in MOLT4 and Jurkat cells.
, 2014 A) Quantitative expression of CXCR7 mRNA in cells relative to the shControl cells. mRNA expression levels of CXCR7 were normalized by HPRT and GAPDH endogenous control. Results were analyzed using 2−ΔΔCT. CXCR7 mRNA expression was reduced in MOLT4 cells (
Mariana Ozello Baratti (517831) +7 more
core +1 more source
Localization and Trafficking of CXCR4 and CXCR7
, 2022 G protein-coupled receptors (GPCRs) constitute the largest class of membrane proteins, and are the master components that translate extracellular stimulus into intracellular signaling, which in turn modulates key physiological and pathophysiological processes.
openaire +1 more source
The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells
Molecular Cancer, 2011 Background Migration of metastatic tumor cells from the bloodstream into lymph nodes is thought to be facilitated by expression of the chemokine receptors CCR7, CXCR4 and, for B cell-derived tumors, CXCR5. Expression of their respective chemokine ligands
Jaén Juan C +4 more
doaj +1 more source
Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.The progression of silicosis‐associated fibrosis relies on a positive feedback loop mediated by crosstalk between Cxcr4+ macrophages and Cxcl12+ fibroblasts and the therapeutic potential of targeting the Cxcl12/Cxcr4 axis with AMD3100 as a novel strategy for treating silicosis.
Min Mu +11 more
wiley +1 more source
Discovery of Amantamide, a Selective CXCR7 Agonist from Marine Cyanobacteria
, 2019 CXCR7 plays an emerging role in several physiological processes. A linear peptide, amantamide (1), was isolated from marine cyanobacteria, and the structure was determined by NMR and mass spectrometry.
Danmeng Luo (1433326) +9 more
core +1 more source