Stem Cell Research & Therapy, 2021 Background Endothelial progenitor cell (EPC) dysfunction contributes to vascular disease in diabetes mellitus. However, the molecular mechanism underlying EPC dysfunction and its contribution to delayed reendothelialization in diabetes mellitus remain ...
Chunyu Jiang +8 more
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Chemokine receptor CXCR7 is a functional receptor for CXCL12 in brain endothelial cells. [PDF]
PLoS ONE, 2014 The chemokine CXCL12 regulates multiple cell functions through its receptor, CXCR4. However, recent studies have shown that CXCL12 also binds a second receptor, CXCR7, to potentiate signal transduction and cell activity.
Yang Liu +2 more
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CXC chemokine receptor 7 (CXCR7) regulates CXCR4 protein expression and capillary tuft development in mouse kidney. [PDF]
PLoS ONE, 2012 BACKGROUND: The CXCL12/CXCR4 axis is involved in kidney development by regulating formation of the glomerular tuft. Recently, a second CXCL12 receptor was identified and designated CXCR7.
Sammy Haege +8 more
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Expression and functional heterogeneity of chemokine receptors CXCR4 and CXCR7 in primary patient-derived glioblastoma cells. [PDF]
PLoS ONE, 2013 Glioblastoma (GBM) is the most common primary brain tumor in adults. The poor prognosis and minimally successful treatments of these tumors indicates a need to identify new therapeutic targets. Therapy resistance of GBMs is attributed to heterogeneity of
Che Liu +6 more
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Chemokine receptor CXCR7 antagonism ameliorates cardiac and renal fibrosis induced by mineralocorticoid excess. [PDF]
Sci RepCardiorenal fibrosis is a common feature of chronic cardiovascular disease and recent data suggests that cytokines and chemokines may also drive fibrosis.
Wang BH +6 more
europepmc +2 more sources
Modulators of CXCR4 and CXCR7/ACKR3 Function [PDF]
Molecular Pharmacology, 2019 The two G protein-coupled receptors (GPCRs) C-X-C chemokine receptor type 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) are part of the class A chemokine GPCR family and represent important drug targets for human immunodeficiency virus (HIV) infection, cancer, and inflammation diseases.
Adlere, Ilze +13 more
openaire +3 more sources
Profiling of Cxcl12 receptors, Cxcr4 and Cxcr7 in murine testis development and a spermatogenic depletion model indicates a role for Cxcr7 in controlling Cxcl12 activity. [PDF]
PLoS ONE, 2014 In mice the chemokine Cxcl12 and its receptor Cxcr4 participate in maintenance of the spermatogonial population during postnatal development. More complexity arises since Cxcl12 also binds to the non-classical/atypical chemokine receptor Cxcr7.
Birgit Westernströer +5 more
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Stem Cell Research & Therapy, 2021 Background The major barriers to mesenchymal stem cell (MSC) therapy in rheumatoid arthritis (RA) are a low extent of tissue regeneration and insufficient immunomodulation after cell transplantation. In addition, the role of C-X-C chemokine receptor type
Sung-Tai Wei +7 more
doaj +1 more source
Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma. [PDF]
PLoS ONE, 2012 Neuroblastoma (NB) is a typical childhood and heterogeneous neoplasm for which efficient targeted therapies for high-risk tumors are not yet identified.
Julie Liberman +8 more
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Frontiers in Genetics, 2021 We found that SDF-1/CXCR7 axis played an important role in the growth and proliferation of gastric cancer in the previous studies. The objectives of this study were to explore the effects of SDF-1/CXCR7 on the metastatic ability of gastric cancer cells ...
Ameng Shi +4 more
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