Results 21 to 30 of about 6,662 (210)
Inhibition of CXCR4 and CXCR7 Is Protective in Acute Peritoneal Inflammation [PDF]
Frontiers in Immunology, 2020 Our previous studies revealed a pivotal role of the chemokine stromal cell-derived factor (SDF)-1 and its receptors CXCR4 and CXCR7 on migratory behavior of polymorphonuclear granulocytes (PMNs) in pulmonary inflammation.
Kristian-Christos Ngamsri +7 more
doaj +4 more sources
CXCR7 Is Involved in Human Oligodendroglial Precursor Cell Maturation. [PDF]
PLoS ONE, 2016 Differentiation of oligodendroglial precursor cells (OPCs), a crucial prerequisite for central nervous system (CNS) remyelination in diseases such as Multiple Sclerosis (MS), is modulated by a multitude of extrinsic and intrinsic factors.
David Kremer +6 more
doaj +5 more sources
CXCL12/CXCR4/CXCR7 axis in placenta tissues of patients with placenta previa
Open Life Sciences, 2023 CXCR4 and CXCR7 have been revealed to be receptors of CXCL12. This research was designed to probe the expression of chemokine CXCL12 and its receptors CXCR4 and CXCR7 in placental tissues of patients with placenta previa and the effect of CXCL12/CXCR4 ...
Wu Xia, Wang Ying, Li Min
doaj +1 more source
Stem Cell Research & Therapy, 2021 Background Endothelial progenitor cell (EPC) dysfunction contributes to vascular disease in diabetes mellitus. However, the molecular mechanism underlying EPC dysfunction and its contribution to delayed reendothelialization in diabetes mellitus remain ...
Chunyu Jiang +8 more
doaj +1 more source
CXCR7 expression in esophageal cancer [PDF]
Journal of Translational Medicine, 2013 The chemokine CXCL12 and its receptor CXCR4 play a major role in tumor invasion, proliferation and metastasis in different malignant diseases, including esophageal carcinoma, amongst others. CXCR7 was recently identified as a novel alternate receptor for CXCL12.
Tachezy, Michael +6 more
openaire +2 more sources
Chemokine receptor CXCR7 is a functional receptor for CXCL12 in brain endothelial cells. [PDF]
PLoS ONE, 2014 The chemokine CXCL12 regulates multiple cell functions through its receptor, CXCR4. However, recent studies have shown that CXCL12 also binds a second receptor, CXCR7, to potentiate signal transduction and cell activity.
Yang Liu +2 more
doaj +1 more source
CXC chemokine receptor 7 (CXCR7) regulates CXCR4 protein expression and capillary tuft development in mouse kidney. [PDF]
PLoS ONE, 2012 BACKGROUND: The CXCL12/CXCR4 axis is involved in kidney development by regulating formation of the glomerular tuft. Recently, a second CXCL12 receptor was identified and designated CXCR7.
Sammy Haege +8 more
doaj +1 more source
Modulators of CXCR4 and CXCR7/ACKR3 Function [PDF]
Molecular Pharmacology, 2019 The two G protein-coupled receptors (GPCRs) C-X-C chemokine receptor type 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) are part of the class A chemokine GPCR family and represent important drug targets for human immunodeficiency virus (HIV) infection, cancer, and inflammation diseases.
Adlere, Ilze +13 more
openaire +3 more sources
Stem Cell Research & Therapy, 2021 Background The major barriers to mesenchymal stem cell (MSC) therapy in rheumatoid arthritis (RA) are a low extent of tissue regeneration and insufficient immunomodulation after cell transplantation. In addition, the role of C-X-C chemokine receptor type
Sung-Tai Wei +7 more
doaj +1 more source
CXCR7-mediated progression of osteosarcoma in the lungs [PDF]
British Journal of Cancer, 2013 Osteosarcoma (OS) is the most frequent primary malignant bone tumour in children and adolescents with a high propensity for lung metastasis. Chemokines and chemokine receptors have been described to have an important role in many malignancies including OS.
Goguet-Surmenian, E +10 more
openaire +2 more sources