Results 21 to 30 of about 6,925 (209)
Expression and function of CXCR7 in the mouse forebrain
Journal of Neuroimmunology, 2010 The chemokine CXCL12/CXCR4 signaling system is important for the regulation of neuron migration in the developing forebrain. In particular it is crucial for correct distribution of Cajal-Retzius cells and migration of cortical interneurons.
Moepps, B +4 more
core +5 more sources
Chemokine receptor CXCR7 is a functional receptor for CXCL12 in brain endothelial cells. [PDF]
PLoS ONE, 2014 The chemokine CXCL12 regulates multiple cell functions through its receptor, CXCR4. However, recent studies have shown that CXCL12 also binds a second receptor, CXCR7, to potentiate signal transduction and cell activity.
Yang Liu +2 more
doaj +1 more source
CXC chemokine receptor 7 (CXCR7) regulates CXCR4 protein expression and capillary tuft development in mouse kidney. [PDF]
PLoS ONE, 2012 BACKGROUND: The CXCL12/CXCR4 axis is involved in kidney development by regulating formation of the glomerular tuft. Recently, a second CXCL12 receptor was identified and designated CXCR7.
Sammy Haege +8 more
doaj +1 more source
Stem Cell Research & Therapy, 2021 Background The major barriers to mesenchymal stem cell (MSC) therapy in rheumatoid arthritis (RA) are a low extent of tissue regeneration and insufficient immunomodulation after cell transplantation. In addition, the role of C-X-C chemokine receptor type
Sung-Tai Wei +7 more
doaj +1 more source
Frontiers in Genetics, 2021 We found that SDF-1/CXCR7 axis played an important role in the growth and proliferation of gastric cancer in the previous studies. The objectives of this study were to explore the effects of SDF-1/CXCR7 on the metastatic ability of gastric cancer cells ...
Ameng Shi +4 more
doaj +1 more source
Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma. [PDF]
PLoS ONE, 2012 Neuroblastoma (NB) is a typical childhood and heterogeneous neoplasm for which efficient targeted therapies for high-risk tumors are not yet identified.
Julie Liberman +8 more
doaj +1 more source
CXCR7 expression in esophageal cancer [PDF]
Journal of Translational Medicine, 2013 The chemokine CXCL12 and its receptor CXCR4 play a major role in tumor invasion, proliferation and metastasis in different malignant diseases, including esophageal carcinoma, amongst others. CXCR7 was recently identified as a novel alternate receptor for CXCL12.
Tachezy, Michael +6 more
openaire +2 more sources
Modulators of CXCR4 and CXCR7/ACKR3 Function [PDF]
Molecular Pharmacology, 2019 The two G protein-coupled receptors (GPCRs) C-X-C chemokine receptor type 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) are part of the class A chemokine GPCR family and represent important drug targets for human immunodeficiency virus (HIV) infection, cancer, and inflammation diseases.
Adlere, Ilze +13 more
openaire +3 more sources
Lipopolysaccharide Promotes Choroidal Neovascularization by Up-Regulation of CXCR4 and CXCR7 Expression in Choroid Endothelial Cell. [PDF]
PLoS ONE, 2015 Stromal cell-derived factor-1 (SDF-1) has been confirmed to participate in the formation of choroidal neovascularization (CNV) via its two receptors: CXC chemokine receptors 4 (CXCR4) and CXCR7. Previous studies have indicated that the activation of Toll-
Yi-fan Feng +3 more
doaj +1 more source
CXCR7 in tumorigenesis and progression
Chinese Journal of Cancer, 2010 Chemokines, a family of small cytokines, were initially characterized as proinflammatory chemoattractant cytokines that regulated cell trafficking and adhesion. Today, attention focuses on chemokines because evidence shows that they play a critical role in tumor initiation, promotion, and progression.
Kai-Lin, Hou +3 more
openaire +2 more sources