Results 31 to 40 of about 6,925 (209)

Atypical Roles of the Chemokine Receptor ACKR3/CXCR7 in Platelet Pathophysiology

Cells, 2022
The manifold actions of the pro-inflammatory and regenerative chemokine CXCL12/SDF-1α are executed through the canonical GProteinCoupledReceptor CXCR4, and the non-canonical ACKR3/CXCR7.
Madhumita Chatterjee
doaj   +1 more source

Pathogenic role of CXCR7 in rheumatoid arthritis [PDF]

Arthritis & Rheumatism, 2010
AbstractObjectiveThe interaction between CXCL12 and its receptor, CXCR4, in the synovium of patients with rheumatoid arthritis (RA) is important for local inflammatory cell recruitment, angiogenesis, and cytokine production. CXCR7 was recently identified as an alternative receptor for CXCL12.
Kaori, Watanabe, Mark E T, Penfold, Akio, Matsuda, Naho, Ohyanagi, Kayoko, Kaneko, Yoshishige, Miyabe, Kenji, Matsumoto, Thomas J, Schall, Nobuyuki, Miyasaka, Toshihiro, Nanki   +9 more
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Chemokine receptor CXCR7 activates Aurora Kinase A and promotes neuroendocrine prostate cancer growth

The Journal of Clinical Investigation, 2023
CXCR7 is an atypical chemokine receptor that recruits β-arrestin (ARRB2) and internalizes into clathrin-coated intracellular vesicles where the complex acts as a scaffold for cytoplasmic kinase assembly and signal transduction. Here, we report that CXCR7
Galina Gritsina, Ka-wing Fong, Xiaodong Lu, Zhuoyuan Lin, Wanqing Xie, Shivani Agarwal, Dong Lin, Gary E. Schiltz, Himisha Beltran, Eva Corey, Colm Morrissey, Yuzhuo Wang, Jonathan C. Zhao, Maha Hussain, Jindan Yu   +14 more
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Regulation of the Hippo/YAP axis by CXCR7 in the tumorigenesis of gastric cancer

Journal of Experimental & Clinical Cancer Research, 2023
Background The Hippo pathway is crucial in organ size control and tumorigenesis. Dysregulation of the Hippo/YAP axis is commonly observed in gastric cancer, while effective therapeutic targets for the Hippo/YAP axis are lacking.
Tianshi Wang, Dehai Wang, Yanan Sun, Ting Zhuang, Xin Li, Huijie Yang, Yifeng Zang, Ziping Liu, Penghe Yang, Chenmiao Zhang, Jiayao Cui, Mingxi Fu, Shuqing Zhang, Peng Su, Zhongbo Li, Jian Zhu, Yinlu Ding   +16 more
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CXCR7/p-ERK-Signaling Is a Novel Target for Therapeutic Vasculogenesis in Patients with Coronary Artery Disease. [PDF]

PLoS ONE, 2016
Coronary artery disease (CAD) is characterized by insufficient vasculogenic response to ischemia, which is typically accompanied by dysfunction of endothelial outgrowth cells (EOCs).
Zheng Cao, Xinzhu Tong, Wenhao Xia, Long Chen, Xiaoyu Zhang, Bingbo Yu, Zhen Yang, Jun Tao   +7 more
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CXCR3, CXCR5, CXCR6, and CXCR7 in Diabetes [PDF]

Current Drug Targets, 2016
Many studies have suggested that CXCR3, CXCR5, CXCR6 and CXCR7 chemokine receptors are determinant in type 1 diabetes (T1D), expecially in autoimmunity and β-cell destruction. In particular circulating CXCL10 level (the ligand of CXCR3) is high in T1D patients, and this suggests that CXCL10 may be a candidate for a predictive marker of T1D.
Fallahi, P., Corrado, A., Di Domenicantonio, A., FRENZILLI, GIADA, ANTONELLI, ALESSANDRO, Ferrari, S. M.   +5 more
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Chemokine receptor 7 targets the vascular endothelial growth factor via the AKT/ERK pathway to regulate angiogenesis in colon cancer

Cancer Medicine, 2019
Background Studies have shown that CXCR7 is expressed in many tumors. The aim of the present study was to investigate the function of CXCR7 in colon cancer.
Xiang Li, Xuemei Wang, Zitao Li, Zhen Zhang, Yixia Zhang   +4 more
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CXCR7-mediated progression of osteosarcoma in the lungs [PDF]

British Journal of Cancer, 2013
Osteosarcoma (OS) is the most frequent primary malignant bone tumour in children and adolescents with a high propensity for lung metastasis. Chemokines and chemokine receptors have been described to have an important role in many malignancies including OS.
Goguet-Surmenian, E, Richard-Fiardo, P, Guillemot, E, Benchetrit, M, Gomez-Brouchet, A, Buzzo, P, Karimdjee-Soilihi, B, Alemanno, P, Michiels, J-F, Schmid-Alliana, A, Schmid-Antomarchi, H   +10 more
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Chemokine receptor CXCR7 regulates the invasion, angiogenesis and tumor growth of human hepatocellular carcinoma cells

Journal of Experimental & Clinical Cancer Research, 2010
Background In spite of recent advances in diagnostic and therapeutic measures, the prognosis of hepatocellular carcinoma (HCC) patients remains poor.
Li Fan, Tian Tian, Wang Xiao-Yi, Su Xin-Liang, Li Hong-Yuan, Zheng Ke, Ren Guo-Sheng   +6 more
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Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

Nature Communications, 2023
Chemokine receptors constitute an important subfamily of G protein-coupled receptors (GPCRs), and they are critically involved in a broad range of immune response mechanisms.
Parishmita Sarma, Carlo Marion C. Carino, Deeksha Seetharama, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Xue Rui, Yubo Cao, Kouki Kawakami, Poonam Kumari, Yu-Chih Chen, Kathryn E. Luker, Prem N. Yadav, Gary D. Luker, Stéphane A. Laporte, Xin Chen, Asuka Inoue, Arun K. Shukla   +16 more
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