Results 31 to 40 of about 6,662 (210)
CXCR3, CXCR5, CXCR6, and CXCR7 in Diabetes [PDF]
Current Drug Targets, 2016 Many studies have suggested that CXCR3, CXCR5, CXCR6 and CXCR7 chemokine receptors are determinant in type 1 diabetes (T1D), expecially in autoimmunity and β-cell destruction. In particular circulating CXCL10 level (the ligand of CXCR3) is high in T1D patients, and this suggests that CXCL10 may be a candidate for a predictive marker of T1D.
Fallahi, P. +5 more
openaire +3 more sources
Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma. [PDF]
PLoS ONE, 2012 Neuroblastoma (NB) is a typical childhood and heterogeneous neoplasm for which efficient targeted therapies for high-risk tumors are not yet identified.
Julie Liberman +8 more
doaj +1 more source
Frontiers in Genetics, 2021 We found that SDF-1/CXCR7 axis played an important role in the growth and proliferation of gastric cancer in the previous studies. The objectives of this study were to explore the effects of SDF-1/CXCR7 on the metastatic ability of gastric cancer cells ...
Ameng Shi +4 more
doaj +1 more source
Pathogenic role of CXCR7 in rheumatoid arthritis [PDF]
Arthritis & Rheumatism, 2010 AbstractObjectiveThe interaction between CXCL12 and its receptor, CXCR4, in the synovium of patients with rheumatoid arthritis (RA) is important for local inflammatory cell recruitment, angiogenesis, and cytokine production. CXCR7 was recently identified as an alternative receptor for CXCL12.
Kaori, Watanabe +9 more
openaire +2 more sources
CXCR7 in tumorigenesis and progression
Chinese Journal of Cancer, 2010 Chemokines, a family of small cytokines, were initially characterized as proinflammatory chemoattractant cytokines that regulated cell trafficking and adhesion. Today, attention focuses on chemokines because evidence shows that they play a critical role in tumor initiation, promotion, and progression.
Kai-Lin, Hou +3 more
openaire +2 more sources
Regulation of the Hippo/YAP axis by CXCR7 in the tumorigenesis of gastric cancer
Journal of Experimental & Clinical Cancer Research, 2023 Background The Hippo pathway is crucial in organ size control and tumorigenesis. Dysregulation of the Hippo/YAP axis is commonly observed in gastric cancer, while effective therapeutic targets for the Hippo/YAP axis are lacking.
Tianshi Wang +16 more
doaj +1 more source
Endothelial CXCR7 regulates breast cancer metastasis [PDF]
Oncogene, 2015 Atypical chemokine receptor CXCR7 (ACKR3) functions as a scavenger receptor for chemokine CXCL12, a molecule that promotes multiple steps in tumor growth and metastasis in breast cancer and multiple other malignancies. Although normal vascular endothelium expresses low levels of CXCR7, marked upregulation of CXCR7 occurs in tumor vasculature in breast ...
Stacer, Amanda C. +8 more
openaire +2 more sources
The Journal of Clinical Investigation, 2023 CXCR7 is an atypical chemokine receptor that recruits β-arrestin (ARRB2) and internalizes into clathrin-coated intracellular vesicles where the complex acts as a scaffold for cytoplasmic kinase assembly and signal transduction. Here, we report that CXCR7
Galina Gritsina +14 more
doaj +1 more source
Lipopolysaccharide Promotes Choroidal Neovascularization by Up-Regulation of CXCR4 and CXCR7 Expression in Choroid Endothelial Cell. [PDF]
PLoS ONE, 2015 Stromal cell-derived factor-1 (SDF-1) has been confirmed to participate in the formation of choroidal neovascularization (CNV) via its two receptors: CXC chemokine receptors 4 (CXCR4) and CXCR7. Previous studies have indicated that the activation of Toll-
Yi-fan Feng +3 more
doaj +1 more source
Cancer Medicine, 2019 Background Studies have shown that CXCR7 is expressed in many tumors. The aim of the present study was to investigate the function of CXCR7 in colon cancer.
Xiang Li +4 more
doaj +1 more source