Results 41 to 50 of about 599,394 (294)

The role of chemokine receptor CXCR4 in lung cancer [PDF]

Cancer Biology & Therapy, 2010
Lung cancer is the leading cause of cancer deaths worldwide. Small cell lung cancer (SCLC), which comprises 15% of all lung cancers, is almost exclusively due to smoking and is highly aggressive due to early widespread metastasis. While combination chemotherapy has lead to modest improvements in outcome, the five-year overall survival for SCLC remains ...
Tara, Gangadhar, Suvobroto, Nandi, Ravi, Salgia   +2 more
openaire   +2 more sources

Lipopolysaccharide Promotes Choroidal Neovascularization by Up-Regulation of CXCR4 and CXCR7 Expression in Choroid Endothelial Cell. [PDF]

PLoS ONE, 2015
Stromal cell-derived factor-1 (SDF-1) has been confirmed to participate in the formation of choroidal neovascularization (CNV) via its two receptors: CXC chemokine receptors 4 (CXCR4) and CXCR7. Previous studies have indicated that the activation of Toll-
Yi-fan Feng, Hua Guo, Fei Yuan, Min-qian Shen   +3 more
doaj   +1 more source

Chemokine Receptor CXCR4 Expression in Endothelium

Biochemical and Biophysical Research Communications, 1998
The expression of chemokine receptor and viral coreceptor CXCR4 is reported in cultured endothelial cells and in arterial endothelium. A 1.9 kb transcript was cloned from cultured bovine aortic (BAEC) and human umbilical vein endothelial cells (HUVEC).
M V, Volin, L, Joseph, M S, Shockley, P F, Davies   +3 more
openaire   +2 more sources

Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration [PDF]

, 2009
FLT3-ITD-mediated leukemogenesis is associated with increased expression of oncogenic PIM serine/threonine kinases. To dissect their role in FLT3-ITD-mediated transformation, we performed bone marrow reconstitution assays.
Spoo, A, Bullock, AN, Spoo, Anke Cornelia, Duyster, Justus, Pogacic, Vanda, Dechow, Tobias, Andrea Biondi, Grundler, R, Sabine Ehret, Spoo, Anke, Vanda Pogacic, Anke Spoo, Bullock, Alex N., Villa, A, Pogacic, V, Ehret, S, Georgina Berridge, Knapp, S, Dechow, T, Berridge, G, Tobias Dechow, Juerg Schwaller, Christine Dierks, Grundler, Rebekka, Schwaller, J, Duyster, J, Laurent Brault, Bullock, Alexander, Woetzel, S, Antonello Villa, Dierks, Christine, Brault, Laurent, Stefan Knapp, Justus Duyster, Villa, Antonello, Gasser, C, Gasser, Christelle, Rebekka Grundler, Biondi, A, Sabine Woetzel, Brault, L, Woetzel, Sabine, Knapp, Stefan, Schwaller, Juerg, Biondi, Andrea, Dierks, C, Alex N. Bullock, Christelle Gasser, Ehret, Sabine, Wötzel, Sabine, Berridge, Georgina   +50 more
core   +1 more source

Functional role of the CXCR4 chemokine receptor in thyroid cancer [PDF]

, 2009
Thyroid cancer is the most common endocrine malignancy and its incidence is increasing worldwide. We previously found that normal rat thyroid cells, transduced with papillary thyroid cancer (PTC)-related oncogenes, display an inflammatory signature, that
Avilla, Elvira
core   +1 more source

A single site for N-linked glycosylation in the envelope glycoprotein of feline immunodeficiency virus modulates the virus-receptor interaction [PDF]

, 2008
Feline immunodeficiency virus (FIV) targets helper T cells by attachment of the envelope glycoprotein (Env) to CD134, a subsequent interaction with CXCR4 then facilitating the process of viral entry.
Margaret J Hosie, Ayman Samman, Willett Brian J, Samman, Ayman, Logan Nicola, Brian J Willett, Samman Ayman, McMonagle, Elizabeth L., Hosie Margaret J, Logan, Nicola, McMonagle Elizabeth L, Nicola Logan, Hosie, Margaret J., Willett, Brian J., Elizabeth L McMonagle   +14 more
core   +1 more source

Expression and functional heterogeneity of chemokine receptors CXCR4 and CXCR7 in primary patient-derived glioblastoma cells. [PDF]

PLoS ONE, 2013
Glioblastoma (GBM) is the most common primary brain tumor in adults. The poor prognosis and minimally successful treatments of these tumors indicates a need to identify new therapeutic targets. Therapy resistance of GBMs is attributed to heterogeneity of
Che Liu, Kien Pham, Defang Luo, Brent A Reynolds, Parvinder Hothi, Gregory Foltz, Jeffrey K Harrison   +6 more
doaj   +1 more source

Single-Molecule, Super-Resolution, and Functional Analysis of G Protein-Coupled Receptor Behavior Within the T Cell Immunological Synapse

Frontiers in Cell and Developmental Biology, 2021
A central process in immunity is the activation of T cells through interaction of T cell receptors (TCRs) with agonistic peptide-major histocompatibility complexes (pMHC) on the surface of antigen presenting cells (APCs).
James H. Felce, Lucia Parolini, Erdinc Sezgin, Erdinc Sezgin, Pablo F. Céspedes, Kseniya Korobchevskaya, Mathew Jones, Yanchun Peng, Yanchun Peng, Tao Dong, Tao Dong, Marco Fritzsche, Marco Fritzsche, Dirk Aarts, John Frater, John Frater, Michael L. Dustin   +16 more
doaj   +1 more source

Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12 [PDF]

, 2012
Chemokines and their ligands play a critical role in enabling chronic lymphocytic leukaemia (CLL) cells access to protective microenvironmental niches within tissues, ultimately resulting in chemoresistance and relapse: disruption of these signaling ...
McCaig, Alison M., Alison M McCaig, Alison M. Mccaig, Cosimo Emilio, Alison M. Michie, Leach Michael T., Alison M Michie, Emilio Cosimo, Michael T. Leach, McCaig Alison M., Michael T Leach, Michie, Alison M., Michie Alison M., Cosimo, Emilio, Leach, Michael T.   +14 more
core   +1 more source

Establishment of a novel CCR5 and CXCR4 expressing CD4⁺ cell line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists

Retrovirology, 2004
Background CCR5 and CXCR4 are the two main coreceptors essential for HIV entry. Therefore, these chemokine receptors have become important targets in the search for anti-HIV agents.
De Clercq Erik, Vermeire Kurt, Hatse Sigrid, Princen Katrien, Schols Dominique   +4 more
doaj   +1 more source