Results 11 to 20 of about 1,829 (202)

The Role of CXCL12 in Kidney Diseases: A Friend or Foe?

Kidney Diseases, 2021
Background: Chemokines are a family of proteins mainly mediating the homing and migration of various cells. The CXC chemokine CXCL12 is a member of low-weight-molecular chemokines.
Anni Song, Anni Jiang, Wei Xiong, Chun Zhang   +3 more
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mTORC2 mediates CXCL12-induced angiogenesis [PDF]

Angiogenesis, 2016
The chemokine CXCL12, through its receptor CXCR4, positively regulates angiogenesis by promoting endothelial cell (EC) migration and tube formation. However, the relevant downstream signaling pathways in EC have not been defined. Similarly, the upstream activators of mTORC2 signaling in EC are also poorly defined.
Ziegler, Mary E, Hatch, Michaela MS, Wu, Nan, Muawad, Steven A, Hughes, Christopher CW   +4 more
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Glycosaminoglycan silencing by engineered CXCL12 variants [PDF]

FEBS Letters, 2015
We have engineered GPCR (G protein‐coupled receptor) knock‐out and high GAG‐binding affinity into CXCL12α to inhibit CXCL12α‐induced cell migration. Compared to wtCXCL12, the mutant CXCL12α (Δ8 L29K V39K) exhibited a 5.6‐fold and a 2.2‐fold affinity increase for heparin and heparan sulfate, respectively.
Gschwandtner M, Trinker MU, Hecher B, Adage T, Ali S, Kungl AJ   +5 more
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CXCL12 inhibits hair growth through CXCR4

Biomedicine & Pharmacotherapy, 2022
CXCL12 and its receptors, which are highly expressed in the skin, are associated with various cutaneous diseases, including androgenic alopecia. However, their expression and role during the hair cycle are unknown. This study aims to investigate the expression of CXCL12 and its receptor, CXCR4, in the vicinity of hair follicles and their effect on hair
Mei, Zheng, Sang Ho, Oh, Nahyun, Choi, Yong Jin, Choi, Jino, Kim, Jong-Hyuk, Sung   +5 more
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Serum CXCL12 and S100A12 levels in peripheral blood fluid and their correlation with severity in patients with knee osteoarthritis [PDF]

Journal of Medical Biochemistry
Background: This paper aimed to investigate the expression of CXCL12 and S100A12 in peripheral blood (PB) and synovial fluid (SF) of patients with knee osteoarthritis (OS) and to analyze the correlation between them and the severity of knee OS.
LijiangTao, Minjuan He, Yisheng Lu, Jie Zheng, Yili Ye   +4 more
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CXCL12 and CXCR4 as Potential Early Biomarkers for Luminal A and Luminal B Subtypes of Breast Cancer

Cancer Management and Research, 2023
Joanna Motyka,1 Ewa Gacuta,2 Aleksandra Kicman,3 Monika Kulesza,1 Paweł Malinowski,4 Sławomir Ławicki1 1Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland ...
Motyka J, Gacuta E, Kicman A, Kulesza M, Malinowski P, Ławicki S   +5 more
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MiR-886-3p down regulates CXCL12 (SDF1) expression in human marrow stromal cells. [PDF]

PLoS ONE, 2010
Stromal Derived Factor 1 (SDF1 or CXCL12), is a chemokine known to be critical for the migration of cells in several tissue systems including the homing of the hematopoietic stem cell (HSC) to its niche in the bone marrow. A comparative analysis of miRNA
Manoj M Pillai, Xiaodong Yang, Ilango Balakrishnan, Lynne Bemis, Beverly Torok-Storb   +4 more
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Fragment-Based Optimization of Small Molecule CXCL12 Inhibitors for Antagonizing the CXCL12/CXCR4 Interaction [PDF]

Current Topics in Medicinal Chemistry, 2013
The chemokine CXCL12 and its G protein-coupled receptor (GPCR) CXCR4 are high-priority clinical targets because of their involvement in metastatic cancers (also implicated in autoimmune disease and cardiovascular disease). Because chemokines interact with two distinct sites to bind and activate their receptors, both the GPCRs and chemokines are ...
Joshua J, Ziarek, Yan, Liu, Emmanuel, Smith, Guolin, Zhang, Francis C, Peterson, Jun, Chen, Yongping, Yu, Yu, Chen, Brian F, Volkman, Rongshi, Li   +9 more
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Inhibition of nitric oxide synthase activity and chemokine (CXCL12) supplementation can improve hematopoietic reconstitution in mice lethally irradiated by 60Co gamma radiation

Brazilian Journal of Radiation Sciences, 2019
Reduction of nitric oxide (NO) production is related to increased survival in some models of infection and ionizing radiation (IR) exposure. The work used lethally irradiated (60Co, 8Gy) C57Bl6j mice, treated or not with aminoguanidine (AG), an inhibitor
Daniel Perez Vieira, Andrés Jimenez Galisteo Jr., Heitor Franco de Andrade Jr.   +2 more
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Enrichment of Cxcl12 promoter with TET2: A possible link between promoter demethylation and enhanced gene expression in the absence of PARP-1 [PDF]

Archives of Biological Sciences, 2019
Previously, we described the link between C-X-C motif chemokine 12 (Cxcl12) gene induction and DNA hypomethylation in the absence of poly(ADP-ribose) polymerase 1 (PARP-1).
Tolić Anja Z., Rajić Jovana J., Đorđević Marija B., Đorđević Miloš M., Dinić Svetlana S., Grdović Nevena M., Arambašić-Jovanović Jelena D., Mihailović Mirjana V., Poznanović Goran Đ., Jurkowski Tomasz P., Vidaković Melita S., Uskoković Aleksandra S.   +11 more
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